A novel evaluation of microvascular damage in critically ill polytrauma patients by using circulating microRNAs
The management of the critically ill polytrauma patient is complex due to the multiple complications and biochemical and physiopathological imbalances. This happened due to the direct traumatic injury, or due to the post-traumatic events. One of the most complex physiopathology associated to the mul...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2016-03-01
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| Series: | Romanian Journal of Laboratory Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/rrlm-2016-0015 |
| _version_ | 1819017578307125248 |
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| author | Bedreag Ovidiu Horea Rogobete Alexandru Florin Cradigati Carmen Alina Sarandan Mirela Nartita Radu Horhat Florin George Popovici Sonia Elena Sandesc Dorel Papurica Marius |
| author_facet | Bedreag Ovidiu Horea Rogobete Alexandru Florin Cradigati Carmen Alina Sarandan Mirela Nartita Radu Horhat Florin George Popovici Sonia Elena Sandesc Dorel Papurica Marius |
| author_sort | Bedreag Ovidiu Horea |
| collection | DOAJ |
| description | The management of the critically ill polytrauma patient is complex due to the multiple complications and biochemical and physiopathological imbalances. This happened due to the direct traumatic injury, or due to the post-traumatic events. One of the most complex physiopathology associated to the multiple traumas is represented by microvascular damage, subsequently responsible for a series of complications induced through the imbalance of the redox status, severe molecular damage, reduction of the oxygen delivery to the cell and tissues, cell and mitochondrial dead, augmentation of the inflammatory response and finally the installation of multiple organ dysfunction syndrome in this type of patients. A gold goal in the intensive care units is represented by the evaluation and intense monitoring of the molecular and physiopathological dysfunctions of the critically ill patients. Recently, it was intensely researched the use of microRNAs as biomarkers for the specific physiopathological dysfunctions. In this paper we wish to present a series of microRNAs that can serve as biomarkers for the evaluation of microvascular damage, as well as for the evaluation of other specific physiopathology for the critically ill polytrauma patient. |
| first_indexed | 2024-12-21T03:05:45Z |
| format | Article |
| id | doaj.art-2a755477fb3542e097a1026df4ecd990 |
| institution | Directory Open Access Journal |
| issn | 2284-5623 |
| language | English |
| last_indexed | 2024-12-21T03:05:45Z |
| publishDate | 2016-03-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Romanian Journal of Laboratory Medicine |
| spelling | doaj.art-2a755477fb3542e097a1026df4ecd9902022-12-21T19:18:05ZengSciendoRomanian Journal of Laboratory Medicine2284-56232016-03-01241213010.1515/rrlm-2016-0015rrlm-2016-0015A novel evaluation of microvascular damage in critically ill polytrauma patients by using circulating microRNAsBedreag Ovidiu Horea0Rogobete Alexandru Florin1Cradigati Carmen Alina2Sarandan Mirela3Nartita Radu4Horhat Florin George5Popovici Sonia Elena6Sandesc Dorel7Papurica Marius81. Faculty of Medicine, ”Victor Babeș” University of Medicine and Pharmacy, Timișoara, Romania2. Emergency County Hospital Timișoara, Romania3. Clinic of Anesthesia and Intensive Care ”Casa Austria”, Emergency County Hospital ”Pius Brinzeu”, Timișoara, Romania3. Clinic of Anesthesia and Intensive Care ”Casa Austria”, Emergency County Hospital ”Pius Brinzeu”, Timișoara, Romania4. Faculty of Chemistry, Biology, Geography, West University of Timișoara, Timișoara, Romania1. Faculty of Medicine, ”Victor Babeș” University of Medicine and Pharmacy, Timișoara, Romania1. Faculty of Medicine, ”Victor Babeș” University of Medicine and Pharmacy, Timișoara, Romania1. Faculty of Medicine, ”Victor Babeș” University of Medicine and Pharmacy, Timișoara, Romania1. Faculty of Medicine, ”Victor Babeș” University of Medicine and Pharmacy, Timișoara, RomaniaThe management of the critically ill polytrauma patient is complex due to the multiple complications and biochemical and physiopathological imbalances. This happened due to the direct traumatic injury, or due to the post-traumatic events. One of the most complex physiopathology associated to the multiple traumas is represented by microvascular damage, subsequently responsible for a series of complications induced through the imbalance of the redox status, severe molecular damage, reduction of the oxygen delivery to the cell and tissues, cell and mitochondrial dead, augmentation of the inflammatory response and finally the installation of multiple organ dysfunction syndrome in this type of patients. A gold goal in the intensive care units is represented by the evaluation and intense monitoring of the molecular and physiopathological dysfunctions of the critically ill patients. Recently, it was intensely researched the use of microRNAs as biomarkers for the specific physiopathological dysfunctions. In this paper we wish to present a series of microRNAs that can serve as biomarkers for the evaluation of microvascular damage, as well as for the evaluation of other specific physiopathology for the critically ill polytrauma patient.https://doi.org/10.1515/rrlm-2016-0015micrornasmicrovascular diseasepolytrauma patienthypoxiabiomarkers |
| spellingShingle | Bedreag Ovidiu Horea Rogobete Alexandru Florin Cradigati Carmen Alina Sarandan Mirela Nartita Radu Horhat Florin George Popovici Sonia Elena Sandesc Dorel Papurica Marius A novel evaluation of microvascular damage in critically ill polytrauma patients by using circulating microRNAs Romanian Journal of Laboratory Medicine micrornas microvascular disease polytrauma patient hypoxia biomarkers |
| title | A novel evaluation of microvascular damage in critically ill polytrauma patients by using circulating microRNAs |
| title_full | A novel evaluation of microvascular damage in critically ill polytrauma patients by using circulating microRNAs |
| title_fullStr | A novel evaluation of microvascular damage in critically ill polytrauma patients by using circulating microRNAs |
| title_full_unstemmed | A novel evaluation of microvascular damage in critically ill polytrauma patients by using circulating microRNAs |
| title_short | A novel evaluation of microvascular damage in critically ill polytrauma patients by using circulating microRNAs |
| title_sort | novel evaluation of microvascular damage in critically ill polytrauma patients by using circulating micrornas |
| topic | micrornas microvascular disease polytrauma patient hypoxia biomarkers |
| url | https://doi.org/10.1515/rrlm-2016-0015 |
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