Distribution and antifungal susceptibility pattern of Candida species from mainland China: A systematic analysis
Antifungal resistance to Candida pathogens increases morbidity and mortality of immunosuppressive patients, an emerging crisis worldwide. Understanding the Candida prevalence and antifungal susceptibility pattern is necessary to control and treat candidiasis. We aimed to systematically analyse the s...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | Virulence |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/21505594.2022.2123325 |
| _version_ | 1798036420657414144 |
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| author | Hazrat Bilal Muhammad Shafiq Bing Hou Rehmat Islam Muhammad Nadeem Khan Rahat Ullah Khan Yuebin Zeng |
| author_facet | Hazrat Bilal Muhammad Shafiq Bing Hou Rehmat Islam Muhammad Nadeem Khan Rahat Ullah Khan Yuebin Zeng |
| author_sort | Hazrat Bilal |
| collection | DOAJ |
| description | Antifungal resistance to Candida pathogens increases morbidity and mortality of immunosuppressive patients, an emerging crisis worldwide. Understanding the Candida prevalence and antifungal susceptibility pattern is necessary to control and treat candidiasis. We aimed to systematically analyse the susceptibility profiles of Candida species published in the last ten years (December 2011 to December 2021) from mainland China. The studies were collected from PubMed, Google Scholar, and Science Direct search engines. Out of 89 included studies, a total of 44,716 Candida isolates were collected, mainly comprising C. albicans (49.36%), C. tropicalis (21.89%), C. parapsilosis (13.92%), and C. glabrata (11.37%). The lowest susceptibility was detected for azole group; fluconazole susceptibilities against C. parapsilosis, C. albicans, C. glabrata, C. tropicalis, C. guilliermondii, C. pelliculosa, and C. auris were 93.25%, 91.6%, 79.4%, 77.95%, 76%, 50%, and 0% respectively. Amphotericin B and anidulafungin were the most susceptible drugs for all Candida species. Resistance to azole was mainly linked with mutations in ERG11, ERG3, ERG4, MRR1–2, MSH-2, and PDR-1 genes. Mutation in FKS-1 and FKS-2 in C. auris and C. glabrata causing resistance to echinocandins was stated in two studies. Gaps in the studies’ characteristics were detected, such as 79.77%, 47.19 %, 26.97%, 7.86%, and 4.49% studies did not mention the mortality rates, age, gender, breakpoint reference guidelines, and fungal identification method, respectively. The current study demonstrates the overall antifungal susceptibility pattern of Candida species, gaps in surveillance studies and risk-reduction strategies that could be supportive in candidiasis therapy and for the researchers in their future studies. |
| first_indexed | 2024-04-11T21:12:44Z |
| format | Article |
| id | doaj.art-2a75a5088ac144c6b1d4ddf740edfa0f |
| institution | Directory Open Access Journal |
| issn | 2150-5594 2150-5608 |
| language | English |
| last_indexed | 2024-04-11T21:12:44Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Virulence |
| spelling | doaj.art-2a75a5088ac144c6b1d4ddf740edfa0f2022-12-22T04:02:56ZengTaylor & Francis GroupVirulence2150-55942150-56082022-12-011311573158910.1080/21505594.2022.2123325Distribution and antifungal susceptibility pattern of Candida species from mainland China: A systematic analysisHazrat Bilal0Muhammad Shafiq1Bing Hou2Rehmat Islam3Muhammad Nadeem Khan4Rahat Ullah Khan5Yuebin Zeng6Department of Dermatology, The second Affiliated Hospital of Shantou University Medical College, Shantou, ChinaDepartment of Cell Biology and Genetics, Shantou University Medical College, Shantou, ChinaDepartment of laboratory, Shantou Municipal Skin Hospital, Shantou, ChinaKey Laboratory of Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an, ChinaFaculty of Biological Sciences, Department of Microbiology, Quaid-i-Azam University, Islamabad, PakistanInstitute of Microbiology, Faculty of Veterinary and Animal Sciences Gomal University, Dera Ismail Khan, PakistanDepartment of Dermatology, The second Affiliated Hospital of Shantou University Medical College, Shantou, ChinaAntifungal resistance to Candida pathogens increases morbidity and mortality of immunosuppressive patients, an emerging crisis worldwide. Understanding the Candida prevalence and antifungal susceptibility pattern is necessary to control and treat candidiasis. We aimed to systematically analyse the susceptibility profiles of Candida species published in the last ten years (December 2011 to December 2021) from mainland China. The studies were collected from PubMed, Google Scholar, and Science Direct search engines. Out of 89 included studies, a total of 44,716 Candida isolates were collected, mainly comprising C. albicans (49.36%), C. tropicalis (21.89%), C. parapsilosis (13.92%), and C. glabrata (11.37%). The lowest susceptibility was detected for azole group; fluconazole susceptibilities against C. parapsilosis, C. albicans, C. glabrata, C. tropicalis, C. guilliermondii, C. pelliculosa, and C. auris were 93.25%, 91.6%, 79.4%, 77.95%, 76%, 50%, and 0% respectively. Amphotericin B and anidulafungin were the most susceptible drugs for all Candida species. Resistance to azole was mainly linked with mutations in ERG11, ERG3, ERG4, MRR1–2, MSH-2, and PDR-1 genes. Mutation in FKS-1 and FKS-2 in C. auris and C. glabrata causing resistance to echinocandins was stated in two studies. Gaps in the studies’ characteristics were detected, such as 79.77%, 47.19 %, 26.97%, 7.86%, and 4.49% studies did not mention the mortality rates, age, gender, breakpoint reference guidelines, and fungal identification method, respectively. The current study demonstrates the overall antifungal susceptibility pattern of Candida species, gaps in surveillance studies and risk-reduction strategies that could be supportive in candidiasis therapy and for the researchers in their future studies.https://www.tandfonline.com/doi/10.1080/21505594.2022.2123325Candidaantifungal susceptibility patterncandidiasissystematic reviewchina |
| spellingShingle | Hazrat Bilal Muhammad Shafiq Bing Hou Rehmat Islam Muhammad Nadeem Khan Rahat Ullah Khan Yuebin Zeng Distribution and antifungal susceptibility pattern of Candida species from mainland China: A systematic analysis Virulence Candida antifungal susceptibility pattern candidiasis systematic review china |
| title | Distribution and antifungal susceptibility pattern of Candida species from mainland China: A systematic analysis |
| title_full | Distribution and antifungal susceptibility pattern of Candida species from mainland China: A systematic analysis |
| title_fullStr | Distribution and antifungal susceptibility pattern of Candida species from mainland China: A systematic analysis |
| title_full_unstemmed | Distribution and antifungal susceptibility pattern of Candida species from mainland China: A systematic analysis |
| title_short | Distribution and antifungal susceptibility pattern of Candida species from mainland China: A systematic analysis |
| title_sort | distribution and antifungal susceptibility pattern of candida species from mainland china a systematic analysis |
| topic | Candida antifungal susceptibility pattern candidiasis systematic review china |
| url | https://www.tandfonline.com/doi/10.1080/21505594.2022.2123325 |
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