Histopathological study of spectrum of lesions of uterine cervix
Context: Uterine cervix is a gateway to several neoplastic and nonneoplastic lesions. Cervical carcinoma accounts for 20%–25% of all cancers and 80%–85% of all genital tract cancers worldwide. It is the most common malignancy in Indian women. Aim: The aim of this study was to study the histopatholog...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Journal of Mid-Life Health |
| Subjects: | |
| Online Access: | http://www.jmidlifehealth.org/article.asp?issn=0976-7800;year=2023;volume=14;issue=2;spage=112;epage=116;aulast=Jadhav |
| _version_ | 1797645553659543552 |
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| author | Aditi Jadhav Vandana Sanklecha Ashwini Natekar Richa Mahra |
| author_facet | Aditi Jadhav Vandana Sanklecha Ashwini Natekar Richa Mahra |
| author_sort | Aditi Jadhav |
| collection | DOAJ |
| description | Context: Uterine cervix is a gateway to several neoplastic and nonneoplastic lesions. Cervical carcinoma accounts for 20%–25% of all cancers and 80%–85% of all genital tract cancers worldwide. It is the most common malignancy in Indian women. Aim: The aim of this study was to study the histopathological spectrum, incidence, and distribution with respect to the age of various cervical lesions and to determine their clinicopathological correlation. Settings and Design: A prospective observational study of 200 cases of cervical lesions was carried out in the histopathology section of the Department of Pathology for the duration of 2 years after obtaining permission from the Institutional Ethics Committee. Materials and Methods: Study participants were selected from the study population admitted at the study center based on the inclusion and exclusion criteria. Statistical Analysis Used: Statistical software GraphPad InStat.v3.0 was used for statistical analysis. Results: In our study, 49.5% of cases were malignant and 50.5% of cases were benign. The most common malignant lesion on histopathological examination was squamous cell carcinoma (SCC). Majority of the lesions were in the 41–50 years of age group. Clinicopathological agreement was noted in 93.5% of cases. Twenty-eight out of 30 cases of SCC (93.33%) were positive for p16 staining. Agreement between Pap smear findings and histopathological diagnosis was 100% in cases of malignant and premalignant lesions of the cervix. Conclusion: Histopathological examination is important not only for confirmation of the preoperative diagnosis but also in evaluating the incidence and age-wise distribution of both neoplastic and nonneoplastic cervical lesions. Early and accurate diagnosis of cervical lesions provides an opportunity for appropriate interventions to prevent further complications. |
| first_indexed | 2024-03-11T14:48:33Z |
| format | Article |
| id | doaj.art-2a7a102e691b44bca002f189e4b9f604 |
| institution | Directory Open Access Journal |
| issn | 0976-7800 0976-7819 |
| language | English |
| last_indexed | 2024-03-11T14:48:33Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Mid-Life Health |
| spelling | doaj.art-2a7a102e691b44bca002f189e4b9f6042023-10-30T10:27:29ZengWolters Kluwer Medknow PublicationsJournal of Mid-Life Health0976-78000976-78192023-01-0114211211610.4103/jmh.jmh_28_23Histopathological study of spectrum of lesions of uterine cervixAditi JadhavVandana SanklechaAshwini NatekarRicha MahraContext: Uterine cervix is a gateway to several neoplastic and nonneoplastic lesions. Cervical carcinoma accounts for 20%–25% of all cancers and 80%–85% of all genital tract cancers worldwide. It is the most common malignancy in Indian women. Aim: The aim of this study was to study the histopathological spectrum, incidence, and distribution with respect to the age of various cervical lesions and to determine their clinicopathological correlation. Settings and Design: A prospective observational study of 200 cases of cervical lesions was carried out in the histopathology section of the Department of Pathology for the duration of 2 years after obtaining permission from the Institutional Ethics Committee. Materials and Methods: Study participants were selected from the study population admitted at the study center based on the inclusion and exclusion criteria. Statistical Analysis Used: Statistical software GraphPad InStat.v3.0 was used for statistical analysis. Results: In our study, 49.5% of cases were malignant and 50.5% of cases were benign. The most common malignant lesion on histopathological examination was squamous cell carcinoma (SCC). Majority of the lesions were in the 41–50 years of age group. Clinicopathological agreement was noted in 93.5% of cases. Twenty-eight out of 30 cases of SCC (93.33%) were positive for p16 staining. Agreement between Pap smear findings and histopathological diagnosis was 100% in cases of malignant and premalignant lesions of the cervix. Conclusion: Histopathological examination is important not only for confirmation of the preoperative diagnosis but also in evaluating the incidence and age-wise distribution of both neoplastic and nonneoplastic cervical lesions. Early and accurate diagnosis of cervical lesions provides an opportunity for appropriate interventions to prevent further complications.http://www.jmidlifehealth.org/article.asp?issn=0976-7800;year=2023;volume=14;issue=2;spage=112;epage=116;aulast=Jadhavp16 stainingsquamous cell carcinomauterine cervix |
| spellingShingle | Aditi Jadhav Vandana Sanklecha Ashwini Natekar Richa Mahra Histopathological study of spectrum of lesions of uterine cervix Journal of Mid-Life Health p16 staining squamous cell carcinoma uterine cervix |
| title | Histopathological study of spectrum of lesions of uterine cervix |
| title_full | Histopathological study of spectrum of lesions of uterine cervix |
| title_fullStr | Histopathological study of spectrum of lesions of uterine cervix |
| title_full_unstemmed | Histopathological study of spectrum of lesions of uterine cervix |
| title_short | Histopathological study of spectrum of lesions of uterine cervix |
| title_sort | histopathological study of spectrum of lesions of uterine cervix |
| topic | p16 staining squamous cell carcinoma uterine cervix |
| url | http://www.jmidlifehealth.org/article.asp?issn=0976-7800;year=2023;volume=14;issue=2;spage=112;epage=116;aulast=Jadhav |
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