Possible Amelioration of the Severity of Nutritional Steatohepatitis by Guggulsterone in Mice
Non-alcoholic fatty liver disease (NAFLD) has become one of the most common chronic liver diseases worldwide, which characterized by steatosis, inflammation, and fibrosis. The aim of this designed study is to evaluate the ability of guggulsterone to prevent high fat diet induced steatohepatitis in...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
College of Pharmacy University of Baghdad
2019-06-01
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| Series: | Iraqi Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/801 |
| _version_ | 1828412690586927104 |
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| author | Sara Ameen Nafeer Munaf Zalzala |
| author_facet | Sara Ameen Nafeer Munaf Zalzala |
| author_sort | Sara Ameen Nafeer |
| collection | DOAJ |
| description |
Non-alcoholic fatty liver disease (NAFLD) has become one of the most common chronic liver diseases worldwide, which characterized by steatosis, inflammation, and fibrosis. The aim of this designed study is to evaluate the ability of guggulsterone to prevent high fat diet induced steatohepatitis in mice. Five groups of male mice were selected and treated as the following: group I, mice had free access to standard commercial diet and considered as control group, group II, mice were fed a specially formulated high-fat diet for 12 weeks to induce non-alcoholic liver disease, while groups III, IV and V the mice were administered high fat diet containing guggulsterone at 500, 1000 and 2000 ppm concentration respectively for 12 weeks. Maintaining mice on fat rich diet only resulted in inducing the metabolic and histological NAFLD associated. While the treatment with guggulsterone significantly improves the evaluated markers. These results demonstrate guggulsterone may be useful in preventing the development of steatohepatitis.
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| first_indexed | 2024-12-10T12:53:23Z |
| format | Article |
| id | doaj.art-2a7a927edce84753b6b4867700e475c0 |
| institution | Directory Open Access Journal |
| issn | 2521-3512 1683-3597 |
| language | English |
| last_indexed | 2024-12-10T12:53:23Z |
| publishDate | 2019-06-01 |
| publisher | College of Pharmacy University of Baghdad |
| record_format | Article |
| series | Iraqi Journal of Pharmaceutical Sciences |
| spelling | doaj.art-2a7a927edce84753b6b4867700e475c02022-12-22T01:48:09ZengCollege of Pharmacy University of BaghdadIraqi Journal of Pharmaceutical Sciences2521-35121683-35972019-06-0128110.31351/vol28iss1pp17-23801Possible Amelioration of the Severity of Nutritional Steatohepatitis by Guggulsterone in MiceSara Ameen Nafeer0Munaf ZalzalaPharmacist at ministry of health Non-alcoholic fatty liver disease (NAFLD) has become one of the most common chronic liver diseases worldwide, which characterized by steatosis, inflammation, and fibrosis. The aim of this designed study is to evaluate the ability of guggulsterone to prevent high fat diet induced steatohepatitis in mice. Five groups of male mice were selected and treated as the following: group I, mice had free access to standard commercial diet and considered as control group, group II, mice were fed a specially formulated high-fat diet for 12 weeks to induce non-alcoholic liver disease, while groups III, IV and V the mice were administered high fat diet containing guggulsterone at 500, 1000 and 2000 ppm concentration respectively for 12 weeks. Maintaining mice on fat rich diet only resulted in inducing the metabolic and histological NAFLD associated. While the treatment with guggulsterone significantly improves the evaluated markers. These results demonstrate guggulsterone may be useful in preventing the development of steatohepatitis. https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/801guggulsterone steatohepatitis |
| spellingShingle | Sara Ameen Nafeer Munaf Zalzala Possible Amelioration of the Severity of Nutritional Steatohepatitis by Guggulsterone in Mice Iraqi Journal of Pharmaceutical Sciences guggulsterone steatohepatitis |
| title | Possible Amelioration of the Severity of Nutritional Steatohepatitis by Guggulsterone in Mice |
| title_full | Possible Amelioration of the Severity of Nutritional Steatohepatitis by Guggulsterone in Mice |
| title_fullStr | Possible Amelioration of the Severity of Nutritional Steatohepatitis by Guggulsterone in Mice |
| title_full_unstemmed | Possible Amelioration of the Severity of Nutritional Steatohepatitis by Guggulsterone in Mice |
| title_short | Possible Amelioration of the Severity of Nutritional Steatohepatitis by Guggulsterone in Mice |
| title_sort | possible amelioration of the severity of nutritional steatohepatitis by guggulsterone in mice |
| topic | guggulsterone steatohepatitis |
| url | https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/801 |
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