Impaired night-time mobility in patients with Parkinson’s disease: a systematic review
Impaired bed mobility (IBM) is a symptom characteristic of patients having difficulty intentionally moving their bodies during nighttime sleep. IBM is one of the most common nocturnal symptoms of Parkinson’s disease (PD) and may lead to extreme pain and even death; it also increases the burden on th...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1264143/full |
| _version_ | 1797488631765532672 |
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| author | Shengyiwen Li Shengyiwen Li Qingyang Lin Qingyang Lin Yannan Bao Yannan Bao Yichen Feng Dianyou Li Dianyou Li Chencheng Zhang Chencheng Zhang Chencheng Zhang Chencheng Zhang |
| author_facet | Shengyiwen Li Shengyiwen Li Qingyang Lin Qingyang Lin Yannan Bao Yannan Bao Yichen Feng Dianyou Li Dianyou Li Chencheng Zhang Chencheng Zhang Chencheng Zhang Chencheng Zhang |
| author_sort | Shengyiwen Li |
| collection | DOAJ |
| description | Impaired bed mobility (IBM) is a symptom characteristic of patients having difficulty intentionally moving their bodies during nighttime sleep. IBM is one of the most common nocturnal symptoms of Parkinson’s disease (PD) and may lead to extreme pain and even death; it also increases the burden on the patients’ caregivers. In this systematic review, we included 19 studies involving a total of 1,407 patients with PD to observe the causes, assessment methods, and treatment options for IBM. We conclude that the extent of IBM is positively correlated with the severity of symptoms such as disease duration, dyskinesia and decreased sleep quality in patients with PD, and the evidence implies that IBM may be able to serve as a prodromal feature in the development of PD. IBM probably results from low nocturnal dopamine concentrations, reduced function of the spinal tract, torque problems in the muscles, and aging. Therefore, treatment is mostly based on continuously increasing the patient’s nocturnal dopamine concentration, while deep brain stimulation (DBS) also has a mitigating effect on IBM. Both scales and sensors are commonly used to measure the severity of IBM, the wearable device monitoring and scales being updated makes measurements easier and more accurate. The future of the advancement in this field lies in the use of more family-oriented devices (such as smart phones or watches and bracelets, etc.) to monitor IBM’s symptoms and select the appropriate therapeutic treatment according to the severity of the symptoms to relieve patients’ suffering. |
| first_indexed | 2024-03-10T00:06:01Z |
| format | Article |
| id | doaj.art-2a7ae4570efd4df3ad1b0892dcd27543 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-03-10T00:06:01Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-2a7ae4570efd4df3ad1b0892dcd275432023-11-23T16:08:28ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652023-11-011510.3389/fnagi.2023.12641431264143Impaired night-time mobility in patients with Parkinson’s disease: a systematic reviewShengyiwen Li0Shengyiwen Li1Qingyang Lin2Qingyang Lin3Yannan Bao4Yannan Bao5Yichen Feng6Dianyou Li7Dianyou Li8Chencheng Zhang9Chencheng Zhang10Chencheng Zhang11Chencheng Zhang12Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaShanghai Jiao Tong University School of Medicine, Shanghai, ChinaRuijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaShanghai Jiao Tong University School of Medicine, Shanghai, ChinaRuijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaShanghai Jiao Tong University School of Medicine, Shanghai, ChinaShanghai Jiao Tong University School of Biomedical Engineering, Shanghai, ChinaRuijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Neurosurgery, Center for Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaRuijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Neurosurgery, Center for Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Neurosurgery, RuiJin-Mihoyo Laboratory, Clinical Neuroscience Center, RuiJin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaShanghai Research Center for Brain Science and Brain-Inspired Technology, Shanghai, ChinaImpaired bed mobility (IBM) is a symptom characteristic of patients having difficulty intentionally moving their bodies during nighttime sleep. IBM is one of the most common nocturnal symptoms of Parkinson’s disease (PD) and may lead to extreme pain and even death; it also increases the burden on the patients’ caregivers. In this systematic review, we included 19 studies involving a total of 1,407 patients with PD to observe the causes, assessment methods, and treatment options for IBM. We conclude that the extent of IBM is positively correlated with the severity of symptoms such as disease duration, dyskinesia and decreased sleep quality in patients with PD, and the evidence implies that IBM may be able to serve as a prodromal feature in the development of PD. IBM probably results from low nocturnal dopamine concentrations, reduced function of the spinal tract, torque problems in the muscles, and aging. Therefore, treatment is mostly based on continuously increasing the patient’s nocturnal dopamine concentration, while deep brain stimulation (DBS) also has a mitigating effect on IBM. Both scales and sensors are commonly used to measure the severity of IBM, the wearable device monitoring and scales being updated makes measurements easier and more accurate. The future of the advancement in this field lies in the use of more family-oriented devices (such as smart phones or watches and bracelets, etc.) to monitor IBM’s symptoms and select the appropriate therapeutic treatment according to the severity of the symptoms to relieve patients’ suffering.https://www.frontiersin.org/articles/10.3389/fnagi.2023.1264143/fullimpaired bed mobilitynocturnal hypokinesiaParkinson’s disease (PD)movement disordernocturnal akinesia |
| spellingShingle | Shengyiwen Li Shengyiwen Li Qingyang Lin Qingyang Lin Yannan Bao Yannan Bao Yichen Feng Dianyou Li Dianyou Li Chencheng Zhang Chencheng Zhang Chencheng Zhang Chencheng Zhang Impaired night-time mobility in patients with Parkinson’s disease: a systematic review Frontiers in Aging Neuroscience impaired bed mobility nocturnal hypokinesia Parkinson’s disease (PD) movement disorder nocturnal akinesia |
| title | Impaired night-time mobility in patients with Parkinson’s disease: a systematic review |
| title_full | Impaired night-time mobility in patients with Parkinson’s disease: a systematic review |
| title_fullStr | Impaired night-time mobility in patients with Parkinson’s disease: a systematic review |
| title_full_unstemmed | Impaired night-time mobility in patients with Parkinson’s disease: a systematic review |
| title_short | Impaired night-time mobility in patients with Parkinson’s disease: a systematic review |
| title_sort | impaired night time mobility in patients with parkinson s disease a systematic review |
| topic | impaired bed mobility nocturnal hypokinesia Parkinson’s disease (PD) movement disorder nocturnal akinesia |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1264143/full |
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