Mortality prognosis of NGAL, NTproBNP, hsTnT, and GRACE score in patients with acute coronary syndrome
Background: NGAL serum concentration have predictive value for cardiovascular events and mortality in patients with acute coronary syndrome (ACS). Objectives: Assessed the all-cause mortarlity prognosis value of serum neutrophil gelatinase-associated lipocalin (NGAL), combination with N-terminal pro...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | International Journal of Cardiology: Heart & Vasculature |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352906724000046 |
| _version_ | 1827345985928429568 |
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| author | An Viet Tran Nguyet To Tran Khue Duy Nguyen Diem Thi Nguyen Toan Hoang Ngo |
| author_facet | An Viet Tran Nguyet To Tran Khue Duy Nguyen Diem Thi Nguyen Toan Hoang Ngo |
| author_sort | An Viet Tran |
| collection | DOAJ |
| description | Background: NGAL serum concentration have predictive value for cardiovascular events and mortality in patients with acute coronary syndrome (ACS). Objectives: Assessed the all-cause mortarlity prognosis value of serum neutrophil gelatinase-associated lipocalin (NGAL), combination with N-terminal pro B-type natriuretic peptide (NT-proBNP), and hsTnT, and GRACE score in patients with ACS. Materials and methods: We conducted a cross-sectional analysis study used in this study in 58 patients with ACS. Serum NGAL, NT-proBNP, hs-TnT concentration and GRACE score associated with death events (after 3 months of follow-up) were assessed by receiver operating characteristic (ROC) curve. Results: High performance in predicting mortality of NGAL with a cut-off value of 154.55 ng/mL (AUC, 95% CI = 0.96, 0.90 – 1.0; p = 0.001), GRACE score with 140.50 scores (AUC, 95% CI = 0.76, 0.57 – 0.96; p = 0.051). Combination of NTproBNP plus NGAL indicated with the highest value (AUC, 95% CI = 0.96, 0.91 – 1.0; Se = 80.0; Sp = 92.5; p = 0.001). The relative risk assessment indicated a high value in mortality prediction of NGAL with a cut-off value of 154.55 (OR, 95% CI = 49.0, 4.3 – 549.2; p < 0.001), and GRACE score with 140.50 scores (OR, 95% CI = 11.1, 1.1 – 108.4; p = 0.013). Conclusion: NGAL can be employed as a biomarker for the early prediction of mortality events in individuals with ACS. The combination of NGAL, NT-proBNP, hsTnT, and GRACE score showed the higher outcome but not worth mentioning. |
| first_indexed | 2024-03-07T23:21:36Z |
| format | Article |
| id | doaj.art-2a7aef374b004acdad7e513f6a16854d |
| institution | Directory Open Access Journal |
| issn | 2352-9067 |
| language | English |
| last_indexed | 2024-03-07T23:21:36Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Cardiology: Heart & Vasculature |
| spelling | doaj.art-2a7aef374b004acdad7e513f6a16854d2024-02-21T05:29:01ZengElsevierInternational Journal of Cardiology: Heart & Vasculature2352-90672024-02-0150101338Mortality prognosis of NGAL, NTproBNP, hsTnT, and GRACE score in patients with acute coronary syndromeAn Viet Tran0Nguyet To Tran1Khue Duy Nguyen2Diem Thi Nguyen3Toan Hoang Ngo4Department of Internal Medicine, Faculty of Medicine, Can Tho University of Medicine and Pharmacy, Can Tho City 90000, Viet Nam; Department of Interventional Cardiovascular and Neurology, Can Tho University of Medicine and Pharmacy Hospital, Can Tho City 90000, Viet NamCan Tho Cardiovascular Hospital, Can Tho City 90000, Viet NamDepartment of Interventional Cardiovascular and Neurology, Can Tho University of Medicine and Pharmacy Hospital, Can Tho City 90000, Viet NamDepartment of Internal Medicine, Faculty of Medicine, Can Tho University of Medicine and Pharmacy, Can Tho City 90000, Viet NamDepartment of Internal Medicine, Faculty of Medicine, Can Tho University of Medicine and Pharmacy, Can Tho City 90000, Viet Nam; Corresponding author at: Can Tho University of Medicine and Pharmacy, Can Tho City 90000, Viet NamBackground: NGAL serum concentration have predictive value for cardiovascular events and mortality in patients with acute coronary syndrome (ACS). Objectives: Assessed the all-cause mortarlity prognosis value of serum neutrophil gelatinase-associated lipocalin (NGAL), combination with N-terminal pro B-type natriuretic peptide (NT-proBNP), and hsTnT, and GRACE score in patients with ACS. Materials and methods: We conducted a cross-sectional analysis study used in this study in 58 patients with ACS. Serum NGAL, NT-proBNP, hs-TnT concentration and GRACE score associated with death events (after 3 months of follow-up) were assessed by receiver operating characteristic (ROC) curve. Results: High performance in predicting mortality of NGAL with a cut-off value of 154.55 ng/mL (AUC, 95% CI = 0.96, 0.90 – 1.0; p = 0.001), GRACE score with 140.50 scores (AUC, 95% CI = 0.76, 0.57 – 0.96; p = 0.051). Combination of NTproBNP plus NGAL indicated with the highest value (AUC, 95% CI = 0.96, 0.91 – 1.0; Se = 80.0; Sp = 92.5; p = 0.001). The relative risk assessment indicated a high value in mortality prediction of NGAL with a cut-off value of 154.55 (OR, 95% CI = 49.0, 4.3 – 549.2; p < 0.001), and GRACE score with 140.50 scores (OR, 95% CI = 11.1, 1.1 – 108.4; p = 0.013). Conclusion: NGAL can be employed as a biomarker for the early prediction of mortality events in individuals with ACS. The combination of NGAL, NT-proBNP, hsTnT, and GRACE score showed the higher outcome but not worth mentioning.http://www.sciencedirect.com/science/article/pii/S2352906724000046Acute coronary syndromesNeutrophil Gelatinase-Associated LipocalinPro B-type Natriuretic PeptideHigh sensitivity troponin TMortality assessment |
| spellingShingle | An Viet Tran Nguyet To Tran Khue Duy Nguyen Diem Thi Nguyen Toan Hoang Ngo Mortality prognosis of NGAL, NTproBNP, hsTnT, and GRACE score in patients with acute coronary syndrome International Journal of Cardiology: Heart & Vasculature Acute coronary syndromes Neutrophil Gelatinase-Associated Lipocalin Pro B-type Natriuretic Peptide High sensitivity troponin T Mortality assessment |
| title | Mortality prognosis of NGAL, NTproBNP, hsTnT, and GRACE score in patients with acute coronary syndrome |
| title_full | Mortality prognosis of NGAL, NTproBNP, hsTnT, and GRACE score in patients with acute coronary syndrome |
| title_fullStr | Mortality prognosis of NGAL, NTproBNP, hsTnT, and GRACE score in patients with acute coronary syndrome |
| title_full_unstemmed | Mortality prognosis of NGAL, NTproBNP, hsTnT, and GRACE score in patients with acute coronary syndrome |
| title_short | Mortality prognosis of NGAL, NTproBNP, hsTnT, and GRACE score in patients with acute coronary syndrome |
| title_sort | mortality prognosis of ngal ntprobnp hstnt and grace score in patients with acute coronary syndrome |
| topic | Acute coronary syndromes Neutrophil Gelatinase-Associated Lipocalin Pro B-type Natriuretic Peptide High sensitivity troponin T Mortality assessment |
| url | http://www.sciencedirect.com/science/article/pii/S2352906724000046 |
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