The relationship between residential exposure to atmospheric pollution and circulating miRNA in adults living in an urban area in northern France
Introduction: MicroRNAs are epigenetic regulatory factors capable of silencing the expression of target genes and might mediate the effects of air pollution on health. The objective of the present population-based study was to investigate the association between microRNA expression and long-term, re...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-04-01
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| Series: | Environment International |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412023001861 |
| _version_ | 1797839994014924800 |
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| author | Audrey Hubert Djamal Achour Céline Grare Gianni Zarcone Manon Muntaner Aghiles Hamroun Victoria Gauthier Philippe Amouyel Régis Matran Farid Zerimech Jean-Marc Lo-Guidice Luc Dauchet |
| author_facet | Audrey Hubert Djamal Achour Céline Grare Gianni Zarcone Manon Muntaner Aghiles Hamroun Victoria Gauthier Philippe Amouyel Régis Matran Farid Zerimech Jean-Marc Lo-Guidice Luc Dauchet |
| author_sort | Audrey Hubert |
| collection | DOAJ |
| description | Introduction: MicroRNAs are epigenetic regulatory factors capable of silencing the expression of target genes and might mediate the effects of air pollution on health. The objective of the present population-based study was to investigate the association between microRNA expression and long-term, residential exposure to atmospheric PM10 and NO2. Method: We included 998 non-smoking adult participants from the cross-sectional ELISABET survey (2010–2014) in the Lille urban area of France. The mean residential annual pollution levels were estimated with an atmospheric dispersion modelling system. Ten microRNAs were selected on the basis of the literature data, together with two housekeeping microRNAs (miR-93-5p and miR-191-5p) and were quantified with RT-qPCRs. Multivariate linear regression models were used to study the association between microRNAs and air pollution. The threshold for statistical significance (after correction for the FDR) was set to p < 0.1. Results: The mean annual exposure between 2011 and the year of inclusion was 26.4 ± 2.0 µg/m3 for PM10 and 24.7 ± 5.1 µg/m3 for NO2. Each 2 µg/m3 increment in PM10 exposure was associated with an 8.6% increment (95%CI [3.1; 14.3]; pFDR = 0.019) in miR-451a expression.A 5 µg/m3 increment in NO2 exposure was associated with a 5.3% increment ([0.7; 10]; pFDR = 0.056) in miR451a expression, a 3.6% decrement (95%CI [-6.1; −1.1]; pFDR = 0.052) in miR-223-3p expression, a 3.8% decrement (95%CI[-6.8; −0.7]; pFDR = 0.079) in miR-28-3p expression, a 4.3% decrement (95%CI [-7.7; −0.8]; pFDR = 0.055) in miR-146a-5p expression, and a 4.0% decrement (95% CI[−7.4; −0.4]; pFDR = 0.059) in miR-23a-5p expression. The difference between the two housekeeping microRNAs miR-93-5p and miR-191-5p was also associated with PM10 and NO2 exposure. Conclusion: Our results suggest that circulating miRNAs are potentially valuable biomarkers of the effects of air pollution. |
| first_indexed | 2024-04-09T16:07:10Z |
| format | Article |
| id | doaj.art-2a7e0a86675d4ccaad1925a4e5818799 |
| institution | Directory Open Access Journal |
| issn | 0160-4120 |
| language | English |
| last_indexed | 2024-04-09T16:07:10Z |
| publishDate | 2023-04-01 |
| publisher | Elsevier |
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| series | Environment International |
| spelling | doaj.art-2a7e0a86675d4ccaad1925a4e58187992023-04-25T04:07:45ZengElsevierEnvironment International0160-41202023-04-01174107913The relationship between residential exposure to atmospheric pollution and circulating miRNA in adults living in an urban area in northern FranceAudrey Hubert0Djamal Achour1Céline Grare2Gianni Zarcone3Manon Muntaner4Aghiles Hamroun5Victoria Gauthier6Philippe Amouyel7Régis Matran8Farid Zerimech9Jean-Marc Lo-Guidice10Luc Dauchet11Univ. Lille, INSERM, CHU Lille, Institut Pasteur de Lille, U1167 – RID-AGE – Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, F-59000 Lille, FranceUniv. Lille, CHU Lille, Institut Pasteur de Lille, ULR 4483 – IMPECS – IMPact de l’Environnement Chimique sur la Santé, F-59000 Lille, FranceUniv. Lille, CHU Lille, Institut Pasteur de Lille, ULR 4483 – IMPECS – IMPact de l’Environnement Chimique sur la Santé, F-59000 Lille, FranceUniv. Lille, CHU Lille, Institut Pasteur de Lille, ULR 4483 – IMPECS – IMPact de l’Environnement Chimique sur la Santé, F-59000 Lille, FranceUniv. Lille, INSERM, CHU Lille, Institut Pasteur de Lille, U1167 – RID-AGE – Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, F-59000 Lille, FranceUniv. Lille, INSERM, CHU Lille, Institut Pasteur de Lille, U1167 – RID-AGE – Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, F-59000 Lille, FranceUniv. Lille, INSERM, CHU Lille, Institut Pasteur de Lille, U1167 – RID-AGE – Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, F-59000 Lille, FranceUniv. Lille, INSERM, CHU Lille, Institut Pasteur de Lille, U1167 – RID-AGE – Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, F-59000 Lille, FranceUniv. Lille, CHU Lille, Institut Pasteur de Lille, ULR 4483 – IMPECS – IMPact de l’Environnement Chimique sur la Santé, F-59000 Lille, FranceUniv. Lille, CHU Lille, Institut Pasteur de Lille, ULR 4483 – IMPECS – IMPact de l’Environnement Chimique sur la Santé, F-59000 Lille, FranceUniv. Lille, CHU Lille, Institut Pasteur de Lille, ULR 4483 – IMPECS – IMPact de l’Environnement Chimique sur la Santé, F-59000 Lille, FranceUniv. Lille, INSERM, CHU Lille, Institut Pasteur de Lille, U1167 – RID-AGE – Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, F-59000 Lille, France; Corresponding author at: Lille University Medical Center, Epidemiology Unit, Maison Régionale de la Recherche Clinique, 2 rue du Pr. Laguesse, F-59037 Lille cedex, France.Introduction: MicroRNAs are epigenetic regulatory factors capable of silencing the expression of target genes and might mediate the effects of air pollution on health. The objective of the present population-based study was to investigate the association between microRNA expression and long-term, residential exposure to atmospheric PM10 and NO2. Method: We included 998 non-smoking adult participants from the cross-sectional ELISABET survey (2010–2014) in the Lille urban area of France. The mean residential annual pollution levels were estimated with an atmospheric dispersion modelling system. Ten microRNAs were selected on the basis of the literature data, together with two housekeeping microRNAs (miR-93-5p and miR-191-5p) and were quantified with RT-qPCRs. Multivariate linear regression models were used to study the association between microRNAs and air pollution. The threshold for statistical significance (after correction for the FDR) was set to p < 0.1. Results: The mean annual exposure between 2011 and the year of inclusion was 26.4 ± 2.0 µg/m3 for PM10 and 24.7 ± 5.1 µg/m3 for NO2. Each 2 µg/m3 increment in PM10 exposure was associated with an 8.6% increment (95%CI [3.1; 14.3]; pFDR = 0.019) in miR-451a expression.A 5 µg/m3 increment in NO2 exposure was associated with a 5.3% increment ([0.7; 10]; pFDR = 0.056) in miR451a expression, a 3.6% decrement (95%CI [-6.1; −1.1]; pFDR = 0.052) in miR-223-3p expression, a 3.8% decrement (95%CI[-6.8; −0.7]; pFDR = 0.079) in miR-28-3p expression, a 4.3% decrement (95%CI [-7.7; −0.8]; pFDR = 0.055) in miR-146a-5p expression, and a 4.0% decrement (95% CI[−7.4; −0.4]; pFDR = 0.059) in miR-23a-5p expression. The difference between the two housekeeping microRNAs miR-93-5p and miR-191-5p was also associated with PM10 and NO2 exposure. Conclusion: Our results suggest that circulating miRNAs are potentially valuable biomarkers of the effects of air pollution.http://www.sciencedirect.com/science/article/pii/S0160412023001861 |
| spellingShingle | Audrey Hubert Djamal Achour Céline Grare Gianni Zarcone Manon Muntaner Aghiles Hamroun Victoria Gauthier Philippe Amouyel Régis Matran Farid Zerimech Jean-Marc Lo-Guidice Luc Dauchet The relationship between residential exposure to atmospheric pollution and circulating miRNA in adults living in an urban area in northern France Environment International |
| title | The relationship between residential exposure to atmospheric pollution and circulating miRNA in adults living in an urban area in northern France |
| title_full | The relationship between residential exposure to atmospheric pollution and circulating miRNA in adults living in an urban area in northern France |
| title_fullStr | The relationship between residential exposure to atmospheric pollution and circulating miRNA in adults living in an urban area in northern France |
| title_full_unstemmed | The relationship between residential exposure to atmospheric pollution and circulating miRNA in adults living in an urban area in northern France |
| title_short | The relationship between residential exposure to atmospheric pollution and circulating miRNA in adults living in an urban area in northern France |
| title_sort | relationship between residential exposure to atmospheric pollution and circulating mirna in adults living in an urban area in northern france |
| url | http://www.sciencedirect.com/science/article/pii/S0160412023001861 |
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