Therapeutic potential of ginsenosides on diabetes: From hypoglycemic mechanism to clinical trials
Ginsenosides, the main active ingredients in Panax ginseng, have been used as an adjuvant to treat diabetes mellitus for many years. Experimental and clinical data emerge to support antidiabetic efficacy for ginsenosides ascribe to their antioxidant, anti-inflammatory, and anti-hyperglycemic activit...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-01-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464619305547 |
| _version_ | 1818920362323214336 |
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| author | Jing-Wei Shao Jia-Li Jiang Jun-Jie Zou Ming-Yue Yang Fang-Min Chen Yong-Jie Zhang Lee Jia |
| author_facet | Jing-Wei Shao Jia-Li Jiang Jun-Jie Zou Ming-Yue Yang Fang-Min Chen Yong-Jie Zhang Lee Jia |
| author_sort | Jing-Wei Shao |
| collection | DOAJ |
| description | Ginsenosides, the main active ingredients in Panax ginseng, have been used as an adjuvant to treat diabetes mellitus for many years. Experimental and clinical data emerge to support antidiabetic efficacy for ginsenosides ascribe to their antioxidant, anti-inflammatory, and anti-hyperglycemic activities. Existing studies on the mechanisms of ginsenosides in diabetes treatment have mostly focused on single ginenosides and their hypoglycemic effect in cells and animal models. However, a systematical summary of how ginsenosides regulate diabetic-related transcriptional factors and signaling pathways is scarce. Besides, studies on ginsenosides in pharmaceutical preparations have also been limited. Therefore, this review dominantly discusses the roles and mechanisms of ginsenosides in the intervention of blood glucose elevation, as well as the current clinical trials on ginsenosides pharmacology. The elucidation of molecular mechanisms and clinical trials at diabetic status could facilitate ginsenosides application in herbal medicines. |
| first_indexed | 2024-12-20T01:20:33Z |
| format | Article |
| id | doaj.art-2a7e14aca8db4b4787bafde381e2563c |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-20T01:20:33Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-2a7e14aca8db4b4787bafde381e2563c2022-12-21T19:58:26ZengElsevierJournal of Functional Foods1756-46462020-01-0164103630Therapeutic potential of ginsenosides on diabetes: From hypoglycemic mechanism to clinical trialsJing-Wei Shao0Jia-Li Jiang1Jun-Jie Zou2Ming-Yue Yang3Fang-Min Chen4Yong-Jie Zhang5Lee Jia6Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University, Fuzhou 350116, China; Marine Drug R&D Center, Institute of Oceanography, Minjiang University, Fuzhou 350108, China; Corresponding author at: 2 Xueyuan Road, Sunshine Technology Building, 6FL, Fuzhou University, Minhou District, Fuzhou, Fujian 350116, China.Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University, Fuzhou 350116, ChinaFujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University, Fuzhou 350116, ChinaFujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University, Fuzhou 350116, ChinaFujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University, Fuzhou 350116, ChinaFujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University, Fuzhou 350116, ChinaFujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University, Fuzhou 350116, China; Marine Drug R&D Center, Institute of Oceanography, Minjiang University, Fuzhou 350108, ChinaGinsenosides, the main active ingredients in Panax ginseng, have been used as an adjuvant to treat diabetes mellitus for many years. Experimental and clinical data emerge to support antidiabetic efficacy for ginsenosides ascribe to their antioxidant, anti-inflammatory, and anti-hyperglycemic activities. Existing studies on the mechanisms of ginsenosides in diabetes treatment have mostly focused on single ginenosides and their hypoglycemic effect in cells and animal models. However, a systematical summary of how ginsenosides regulate diabetic-related transcriptional factors and signaling pathways is scarce. Besides, studies on ginsenosides in pharmaceutical preparations have also been limited. Therefore, this review dominantly discusses the roles and mechanisms of ginsenosides in the intervention of blood glucose elevation, as well as the current clinical trials on ginsenosides pharmacology. The elucidation of molecular mechanisms and clinical trials at diabetic status could facilitate ginsenosides application in herbal medicines.http://www.sciencedirect.com/science/article/pii/S1756464619305547GinsenosideDiabetes mellitusHyperglycemiaSignaling pathwayClinical trial |
| spellingShingle | Jing-Wei Shao Jia-Li Jiang Jun-Jie Zou Ming-Yue Yang Fang-Min Chen Yong-Jie Zhang Lee Jia Therapeutic potential of ginsenosides on diabetes: From hypoglycemic mechanism to clinical trials Journal of Functional Foods Ginsenoside Diabetes mellitus Hyperglycemia Signaling pathway Clinical trial |
| title | Therapeutic potential of ginsenosides on diabetes: From hypoglycemic mechanism to clinical trials |
| title_full | Therapeutic potential of ginsenosides on diabetes: From hypoglycemic mechanism to clinical trials |
| title_fullStr | Therapeutic potential of ginsenosides on diabetes: From hypoglycemic mechanism to clinical trials |
| title_full_unstemmed | Therapeutic potential of ginsenosides on diabetes: From hypoglycemic mechanism to clinical trials |
| title_short | Therapeutic potential of ginsenosides on diabetes: From hypoglycemic mechanism to clinical trials |
| title_sort | therapeutic potential of ginsenosides on diabetes from hypoglycemic mechanism to clinical trials |
| topic | Ginsenoside Diabetes mellitus Hyperglycemia Signaling pathway Clinical trial |
| url | http://www.sciencedirect.com/science/article/pii/S1756464619305547 |
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