Reconstruction of Critical Nerve Defects Using Allogenic Nerve Tissue: A Review of Current Approaches
Regardless of the nerve defect length, nerve injury is a debilitating condition for the affected patient that results in loss of sensory and motor function. These functional impairments can have a profound impact on the patient’s quality of life. Surgical approaches for the treatment of short segmen...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/7/3515 |
| _version_ | 1797539665970987008 |
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| author | Tim Kornfeld Anton Borger Christine Radtke |
| author_facet | Tim Kornfeld Anton Borger Christine Radtke |
| author_sort | Tim Kornfeld |
| collection | DOAJ |
| description | Regardless of the nerve defect length, nerve injury is a debilitating condition for the affected patient that results in loss of sensory and motor function. These functional impairments can have a profound impact on the patient’s quality of life. Surgical approaches for the treatment of short segment nerve defects are well-established. Autologous nerve transplantation, considered the gold standard, and the use of artificial nerve grafts are safe and successful procedures for short segment nerve defect reconstruction. Long segment nerve defects which extend 3.0 cm or more are more problematic for repair. Methods for reconstruction of long defects are limited. Artificial nerve grafts often fail to regenerate and autologous nerve grafts are limited in length and number. Cadaveric processed/unprocessed nerve allografts are a promising alternative in nerve surgery. This review gives a systematic overview on pre-clinical and clinical approaches in nerve allograft transplantation. |
| first_indexed | 2024-03-10T12:49:06Z |
| format | Article |
| id | doaj.art-2a7fd4bdac6f49fb8cfc11b8500f067f |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T12:49:06Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-2a7fd4bdac6f49fb8cfc11b8500f067f2023-11-21T13:12:47ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-03-01227351510.3390/ijms22073515Reconstruction of Critical Nerve Defects Using Allogenic Nerve Tissue: A Review of Current ApproachesTim Kornfeld0Anton Borger1Christine Radtke2Department of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, AustriaDepartment of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, AustriaDepartment of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, AustriaRegardless of the nerve defect length, nerve injury is a debilitating condition for the affected patient that results in loss of sensory and motor function. These functional impairments can have a profound impact on the patient’s quality of life. Surgical approaches for the treatment of short segment nerve defects are well-established. Autologous nerve transplantation, considered the gold standard, and the use of artificial nerve grafts are safe and successful procedures for short segment nerve defect reconstruction. Long segment nerve defects which extend 3.0 cm or more are more problematic for repair. Methods for reconstruction of long defects are limited. Artificial nerve grafts often fail to regenerate and autologous nerve grafts are limited in length and number. Cadaveric processed/unprocessed nerve allografts are a promising alternative in nerve surgery. This review gives a systematic overview on pre-clinical and clinical approaches in nerve allograft transplantation.https://www.mdpi.com/1422-0067/22/7/3515FDAartificial nerve graftsallograft |
| spellingShingle | Tim Kornfeld Anton Borger Christine Radtke Reconstruction of Critical Nerve Defects Using Allogenic Nerve Tissue: A Review of Current Approaches International Journal of Molecular Sciences FDA artificial nerve grafts allograft |
| title | Reconstruction of Critical Nerve Defects Using Allogenic Nerve Tissue: A Review of Current Approaches |
| title_full | Reconstruction of Critical Nerve Defects Using Allogenic Nerve Tissue: A Review of Current Approaches |
| title_fullStr | Reconstruction of Critical Nerve Defects Using Allogenic Nerve Tissue: A Review of Current Approaches |
| title_full_unstemmed | Reconstruction of Critical Nerve Defects Using Allogenic Nerve Tissue: A Review of Current Approaches |
| title_short | Reconstruction of Critical Nerve Defects Using Allogenic Nerve Tissue: A Review of Current Approaches |
| title_sort | reconstruction of critical nerve defects using allogenic nerve tissue a review of current approaches |
| topic | FDA artificial nerve grafts allograft |
| url | https://www.mdpi.com/1422-0067/22/7/3515 |
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