Sex hormone-dependent and -independent regulation of serum BAFF and TNF in cohorts of transgender and cisgender men and women
Background: The risk of inflammatory diseases is sex-dependent, but it rema ins unknown whether this is due to the impact of sex hormones or sex chromo somes. Transgender individuals represent a unique cohort for studying the relative influence of endocrine and chromosomal factors. Here we compar...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Bioscientifica
2023-02-01
|
| Series: | Endocrine Connections |
| Subjects: | |
| Online Access: | https://ec.bioscientifica.com/view/journals/ec/12/3/EC-22-0456.xml |
| _version_ | 1811172102761349120 |
|---|---|
| author | Christos Tsatsanis Angel Elenkov Irene Leijonhufvud Katerina Vaporidi Åsa Tivesten Aleksander Giwercman |
| author_facet | Christos Tsatsanis Angel Elenkov Irene Leijonhufvud Katerina Vaporidi Åsa Tivesten Aleksander Giwercman |
| author_sort | Christos Tsatsanis |
| collection | DOAJ |
| description | Background: The risk of inflammatory diseases is sex-dependent, but it rema ins unknown
whether this is due to the impact of sex hormones or sex chromo somes. Transgender
individuals represent a unique cohort for studying the relative influence of endocrine
and chromosomal factors. Here we compared serum levels of B-cel l activating-factor
(BAFF) and tumor necrosis factor (TNF) in transgender men (TM), transgender women
(TW), cisgender women (CW) and cisgender men (CM).
Methods: BAFF and TNF were measured in the serum of 26 CW, 30 CM, 27 TM and 16 TW
individuals. To determine the responsiveness of immune cells, T NF was measured in
bacterial lipopolysaccharide (LPS)-treated peripheral leukocytes.
Results: BAFF was higher in CF (998 pg/mL) and TW (973 pg/mL) compared to CM (551
pg/mL) (P < 0.0001) and TM (726 pg/mL) (P < 0.0001). No difference in BAFF levels was
shown between subjects grouped according to the number of X chr omosomes. TNF
was higher in CM (174 pg/mL) than TW (2.3 pg/mL) ( P = 0.027) and TM (27.4 pg/mL)
(P = 0.028). LPS-induced TNF was higher in CM (2524 pg/mL) and TM (2078 pg/mL) than in
CW (1332 pg/mL) (both P < 0.0001) and TW (1602 pg/mL) (both P = 0.009).
Discussion: Sex hormones and sex chromosomes have different impacts on cyto kines
involved in the sex-dependent inflammatory response. The concent ration of BAFF and
LPS-stimulated TNF secretion depended on sex hormone levels, wh ereas basal TNF was
regulated by both sex hormone-dependent and -independent factors. |
| first_indexed | 2024-04-10T17:24:34Z |
| format | Article |
| id | doaj.art-2a819ac9c6014f1a93fb31f16ab3e190 |
| institution | Directory Open Access Journal |
| issn | 2049-3614 |
| language | English |
| last_indexed | 2024-04-10T17:24:34Z |
| publishDate | 2023-02-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrine Connections |
| spelling | doaj.art-2a819ac9c6014f1a93fb31f16ab3e1902023-02-04T15:41:32ZengBioscientificaEndocrine Connections2049-36142023-02-0112318https://doi.org/10.1530/EC-22-0456Sex hormone-dependent and -independent regulation of serum BAFF and TNF in cohorts of transgender and cisgender men and womenChristos Tsatsanis0Angel Elenkov1Irene Leijonhufvud2Katerina Vaporidi3Åsa Tivesten4Aleksander Giwercman5Department of Clinical Chemistry, School of Medicine, University of Crete, Heraklion, Crete, Greece; Molecular Reproductive Research Group, Department of Translational Medicine, Lund University, Malmö, Sweden; Institute of Molecular Biology and Biotechnology, FORTH, Heraklion, GreeceMolecular Reproductive Research Group, Department of Translational Medicine, Lund University, Malmö, Sweden; Reproductive Medicine Centre, Skåne University Hospital Malmö, Malmö, SwedenReproductive Medicine Centre, Skåne University Hospital Malmö, Malmö, SwedenMolecular Reproductive Research Group, Department of Translational Medicine, Lund University, Malmö, SwedenWallenberg Laboratory for Cardiovascular and Metabolic Research, Institute of Medicine, Sahlgrenska University Hospital, Gothenburg, SwedenMolecular Reproductive Research Group, Department of Translational Medicine, Lund University, Malmö, Sweden; Reproductive Medicine Centre, Skåne University Hospital Malmö, Malmö, SwedenBackground: The risk of inflammatory diseases is sex-dependent, but it rema ins unknown whether this is due to the impact of sex hormones or sex chromo somes. Transgender individuals represent a unique cohort for studying the relative influence of endocrine and chromosomal factors. Here we compared serum levels of B-cel l activating-factor (BAFF) and tumor necrosis factor (TNF) in transgender men (TM), transgender women (TW), cisgender women (CW) and cisgender men (CM). Methods: BAFF and TNF were measured in the serum of 26 CW, 30 CM, 27 TM and 16 TW individuals. To determine the responsiveness of immune cells, T NF was measured in bacterial lipopolysaccharide (LPS)-treated peripheral leukocytes. Results: BAFF was higher in CF (998 pg/mL) and TW (973 pg/mL) compared to CM (551 pg/mL) (P < 0.0001) and TM (726 pg/mL) (P < 0.0001). No difference in BAFF levels was shown between subjects grouped according to the number of X chr omosomes. TNF was higher in CM (174 pg/mL) than TW (2.3 pg/mL) ( P = 0.027) and TM (27.4 pg/mL) (P = 0.028). LPS-induced TNF was higher in CM (2524 pg/mL) and TM (2078 pg/mL) than in CW (1332 pg/mL) (both P < 0.0001) and TW (1602 pg/mL) (both P = 0.009). Discussion: Sex hormones and sex chromosomes have different impacts on cyto kines involved in the sex-dependent inflammatory response. The concent ration of BAFF and LPS-stimulated TNF secretion depended on sex hormone levels, wh ereas basal TNF was regulated by both sex hormone-dependent and -independent factors.https://ec.bioscientifica.com/view/journals/ec/12/3/EC-22-0456.xmltnfbaffgenderimmunologyinflammation |
| spellingShingle | Christos Tsatsanis Angel Elenkov Irene Leijonhufvud Katerina Vaporidi Åsa Tivesten Aleksander Giwercman Sex hormone-dependent and -independent regulation of serum BAFF and TNF in cohorts of transgender and cisgender men and women Endocrine Connections tnf baff gender immunology inflammation |
| title | Sex hormone-dependent and -independent regulation of serum BAFF and TNF in cohorts of transgender and cisgender men and women |
| title_full | Sex hormone-dependent and -independent regulation of serum BAFF and TNF in cohorts of transgender and cisgender men and women |
| title_fullStr | Sex hormone-dependent and -independent regulation of serum BAFF and TNF in cohorts of transgender and cisgender men and women |
| title_full_unstemmed | Sex hormone-dependent and -independent regulation of serum BAFF and TNF in cohorts of transgender and cisgender men and women |
| title_short | Sex hormone-dependent and -independent regulation of serum BAFF and TNF in cohorts of transgender and cisgender men and women |
| title_sort | sex hormone dependent and independent regulation of serum baff and tnf in cohorts of transgender and cisgender men and women |
| topic | tnf baff gender immunology inflammation |
| url | https://ec.bioscientifica.com/view/journals/ec/12/3/EC-22-0456.xml |
| work_keys_str_mv | AT christostsatsanis sexhormonedependentandindependentregulationofserumbaffandtnfincohortsoftransgenderandcisgendermenandwomen AT angelelenkov sexhormonedependentandindependentregulationofserumbaffandtnfincohortsoftransgenderandcisgendermenandwomen AT ireneleijonhufvud sexhormonedependentandindependentregulationofserumbaffandtnfincohortsoftransgenderandcisgendermenandwomen AT katerinavaporidi sexhormonedependentandindependentregulationofserumbaffandtnfincohortsoftransgenderandcisgendermenandwomen AT asativesten sexhormonedependentandindependentregulationofserumbaffandtnfincohortsoftransgenderandcisgendermenandwomen AT aleksandergiwercman sexhormonedependentandindependentregulationofserumbaffandtnfincohortsoftransgenderandcisgendermenandwomen |