Emerging role of non-coding RNAs in the regulation of Sonic Hedgehog signaling pathway
Abstract Sonic Hedgehog (Shh) signaling cascade is one of the complex signaling pathways that control the accurately organized developmental processes in multicellular organisms. This pathway has fundamental roles in the tumor formation and induction of resistance to conventional therapies. Numerous...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-09-01
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| Series: | Cancer Cell International |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12935-022-02702-y |
| _version_ | 1811267295481167872 |
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| author | Soudeh Ghafouri-Fard Tayyebeh Khoshbakht Bashdar Mahmud Hussen Mohammad Taheri Majid Samsami |
| author_facet | Soudeh Ghafouri-Fard Tayyebeh Khoshbakht Bashdar Mahmud Hussen Mohammad Taheri Majid Samsami |
| author_sort | Soudeh Ghafouri-Fard |
| collection | DOAJ |
| description | Abstract Sonic Hedgehog (Shh) signaling cascade is one of the complex signaling pathways that control the accurately organized developmental processes in multicellular organisms. This pathway has fundamental roles in the tumor formation and induction of resistance to conventional therapies. Numerous non-coding RNAs (ncRNAs) have been found to interact with Shh pathway to induce several pathogenic processes, including malignant and non-malignant disorders. Many of the Shh-interacting ncRNAs are oncogenes whose expressions have been increased in diverse malignancies. A number of Shh-targeting miRNAs such as miR-26a, miR-1471, miR-129-5p, miR-361-3p, miR-26b-5p and miR-361-3p have been found to be down-regulated in tumor tissues. In addition to malignant conditions, Shh-interacting ncRNAs can affect tissue regeneration and development of neurodegenerative disorders. XIST, LOC101930370, lncRNA-Hh, circBCBM1, SNHG6, LINC‐PINT, TUG1 and LINC01426 are among long non-coding RNAs/circular RNAs that interact with Shh pathway. Moreover, miR-424, miR-26a, miR-1471, miR-125a, miR-210, miR-130a-5p, miR-199b, miR-155, let-7, miR-30c, miR-326, miR-26b-5p, miR-9, miR-132, miR-146a and miR-425-5p are among Shh-interacting miRNAs. The current review summarizes the interactions between ncRNAs and Shh in these contexts. |
| first_indexed | 2024-04-12T21:00:01Z |
| format | Article |
| id | doaj.art-2a823ff01d124e9bbb7b09fc6ec8e38d |
| institution | Directory Open Access Journal |
| issn | 1475-2867 |
| language | English |
| last_indexed | 2024-04-12T21:00:01Z |
| publishDate | 2022-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Cell International |
| spelling | doaj.art-2a823ff01d124e9bbb7b09fc6ec8e38d2022-12-22T03:16:52ZengBMCCancer Cell International1475-28672022-09-0122111510.1186/s12935-022-02702-yEmerging role of non-coding RNAs in the regulation of Sonic Hedgehog signaling pathwaySoudeh Ghafouri-Fard0Tayyebeh Khoshbakht1Bashdar Mahmud Hussen2Mohammad Taheri3Majid Samsami4Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical SciencesPhytochemistry Research Center, Shahid Beheshti University of Medical SciencesDepartment of Pharmacognosy, College of Pharmacy, Hawler Medical UniversityInstitute of Human Genetics, Jena University HospitalCancer Research Center, Shahid Beheshti University of Medical SciencesAbstract Sonic Hedgehog (Shh) signaling cascade is one of the complex signaling pathways that control the accurately organized developmental processes in multicellular organisms. This pathway has fundamental roles in the tumor formation and induction of resistance to conventional therapies. Numerous non-coding RNAs (ncRNAs) have been found to interact with Shh pathway to induce several pathogenic processes, including malignant and non-malignant disorders. Many of the Shh-interacting ncRNAs are oncogenes whose expressions have been increased in diverse malignancies. A number of Shh-targeting miRNAs such as miR-26a, miR-1471, miR-129-5p, miR-361-3p, miR-26b-5p and miR-361-3p have been found to be down-regulated in tumor tissues. In addition to malignant conditions, Shh-interacting ncRNAs can affect tissue regeneration and development of neurodegenerative disorders. XIST, LOC101930370, lncRNA-Hh, circBCBM1, SNHG6, LINC‐PINT, TUG1 and LINC01426 are among long non-coding RNAs/circular RNAs that interact with Shh pathway. Moreover, miR-424, miR-26a, miR-1471, miR-125a, miR-210, miR-130a-5p, miR-199b, miR-155, let-7, miR-30c, miR-326, miR-26b-5p, miR-9, miR-132, miR-146a and miR-425-5p are among Shh-interacting miRNAs. The current review summarizes the interactions between ncRNAs and Shh in these contexts.https://doi.org/10.1186/s12935-022-02702-yShh signalingSonic Hedgehog signalingLong non-coding RNAmiRNA |
| spellingShingle | Soudeh Ghafouri-Fard Tayyebeh Khoshbakht Bashdar Mahmud Hussen Mohammad Taheri Majid Samsami Emerging role of non-coding RNAs in the regulation of Sonic Hedgehog signaling pathway Cancer Cell International Shh signaling Sonic Hedgehog signaling Long non-coding RNA miRNA |
| title | Emerging role of non-coding RNAs in the regulation of Sonic Hedgehog signaling pathway |
| title_full | Emerging role of non-coding RNAs in the regulation of Sonic Hedgehog signaling pathway |
| title_fullStr | Emerging role of non-coding RNAs in the regulation of Sonic Hedgehog signaling pathway |
| title_full_unstemmed | Emerging role of non-coding RNAs in the regulation of Sonic Hedgehog signaling pathway |
| title_short | Emerging role of non-coding RNAs in the regulation of Sonic Hedgehog signaling pathway |
| title_sort | emerging role of non coding rnas in the regulation of sonic hedgehog signaling pathway |
| topic | Shh signaling Sonic Hedgehog signaling Long non-coding RNA miRNA |
| url | https://doi.org/10.1186/s12935-022-02702-y |
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