Unveiling metabolic remodeling in mucopolysaccharidosis type III through integrative metabolomics and pathway analysis

Unveiling metabolic remodeling in mucopolysaccharidosis type III through integrative metabolomics and pathway analysis

Abstract Background Metabolomics represent a valuable tool to recover biological information using body fluids and may help to characterize pathophysiological mechanisms of the studied disease. This approach has not been widely used to explore inherited metabolic diseases. This study investigates mu...

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Main Authors: Abdellah Tebani, Lenaig Abily-Donval, Isabelle Schmitz-Afonso, Bénédicte Héron, Monique Piraud, Jérôme Ausseil, Farid Zerimech, Bruno Gonzalez, Stéphane Marret, Carlos Afonso, Soumeya Bekri
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Journal of Translational Medicine
Subjects:
Metabolomics
Inborn errors of metabolism
Mucopolysaccharidosis type III
Lysosomal storage diseases
Mass spectrometry
Ion mobility
Online Access:http://link.springer.com/article/10.1186/s12967-018-1625-1

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