Relationship of low serum 25 (OH) Vitamin D and dementia – A cross-sectional observational study from a neurology teaching hospital in East India: Relationship of low serum 25 (OH) Vitamin D and dementia in East India
Background: In view of the rapidly growing number of aged population with dementia in India, widespread hypovitaminosis D in the elderly individual, high frequency of dementia of unknown etiology, many studies showing a definite role of Vitamin D in dementia as well as some of the literature showing...
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| Format: | Article |
| Language: | English |
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Manipal College of Medical Sciences, Pokhara
2022-12-01
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| Series: | Asian Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://www.nepjol.info/index.php/AJMS/article/view/48716 |
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| author | Amar Kumar Misra Annesh Bhattacharjee Joydeep Mukherjee Sanjay Kumar Bijendra Mohanty |
| author_facet | Amar Kumar Misra Annesh Bhattacharjee Joydeep Mukherjee Sanjay Kumar Bijendra Mohanty |
| author_sort | Amar Kumar Misra |
| collection | DOAJ |
| description | Background: In view of the rapidly growing number of aged population with dementia in India, widespread hypovitaminosis D in the elderly individual, high frequency of dementia of unknown etiology, many studies showing a definite role of Vitamin D in dementia as well as some of the literature showing inconsistent results and reverse causality of hypovitaminosis D in dementia, we planned to investigate the relation between low vitamin D and risk of dementia.
Aims and Objective: The aim of the current study was to find out any relationship of Vitamin D with dementia.
Materials and Methods: This cross-sectional observational study was performed at a neurology-teaching hospital, Kolkata, India. Ethical clearance was obtained from the hospital ethics committee. A total of fifty adults completed interviews on a semi-structured questionnaire. In addition, general medical and neurological examination and detailed cognitive assessment, including MMSE, were carried out after taking written consent. All individuals with dementia, and age-gender-matched healthy volunteers provided blood samples for routine and relevant biochemical examination, including the estimation of serum 25(OH) Vitamin D by Chemiluminescence Immuno Assay (CLIA). In addition, appropriate statistical methods were applied to analyse the results.
Results: Overall, ninety percent of participants had low serum 25(OH)Vitamin D, defined as 25(OH)D < 20mg/ml. Hypovitaminosis D was associated with early and late-stage dementia and was statistically significant. Only five individuals were found to have sufficient 25 (OH) Vitamin D.
Conclusion: The mean vitamin D level of demented patients was significantly lower compared to the control population. Our observations provide an association between Vitamin D deficiency and dementia and provides a background of longitudinal prospective study in future to show cause and effect relationship between dementia and hypovitaminosis D. |
| first_indexed | 2024-04-11T15:14:36Z |
| format | Article |
| id | doaj.art-2a832d8e024a4b6da2361805fb56e43e |
| institution | Directory Open Access Journal |
| issn | 2467-9100 2091-0576 |
| language | English |
| last_indexed | 2024-04-11T15:14:36Z |
| publishDate | 2022-12-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj.art-2a832d8e024a4b6da2361805fb56e43e2022-12-22T04:16:32ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762022-12-0113126672https://doi.org/10.3126/ajms.v13i12.48716Relationship of low serum 25 (OH) Vitamin D and dementia – A cross-sectional observational study from a neurology teaching hospital in East India: Relationship of low serum 25 (OH) Vitamin D and dementia in East IndiaAmar Kumar Misra 0https://orcid.org/0000-0002-0971-1218Annesh Bhattacharjee 1https://orcid.org/0000-0001-6560-2692Joydeep Mukherjee 2https://orcid.org/0000-0003-0056-1150Sanjay Kumar 3https://orcid.org/0000-0002-5068-6405Bijendra Mohanty 4https://orcid.org/0000-0003-4229-5612Professor and Head, Department of Neuromedicine, Nil Ratan Sircar Medical College and Hospital, Kolkata, West Bengal, India Senior Resident, Department of Neuromedicine, Nil Ratan Sircar Medical College and Hospital, Kolkata, West Bengal, India Assistant Professor, Department of Neuromedicine, Nil Ratan Sircar Medical College and Hospital, Kolkata, West Bengal, India Professor, Department of Neurology, Patna Medical College, Patna, Bihar, India Senior Resident, Department of Neuromedicine, Nil Ratan Sircar Medical College and Hospital, Kolkata, West Bengal, India Background: In view of the rapidly growing number of aged population with dementia in India, widespread hypovitaminosis D in the elderly individual, high frequency of dementia of unknown etiology, many studies showing a definite role of Vitamin D in dementia as well as some of the literature showing inconsistent results and reverse causality of hypovitaminosis D in dementia, we planned to investigate the relation between low vitamin D and risk of dementia. Aims and Objective: The aim of the current study was to find out any relationship of Vitamin D with dementia. Materials and Methods: This cross-sectional observational study was performed at a neurology-teaching hospital, Kolkata, India. Ethical clearance was obtained from the hospital ethics committee. A total of fifty adults completed interviews on a semi-structured questionnaire. In addition, general medical and neurological examination and detailed cognitive assessment, including MMSE, were carried out after taking written consent. All individuals with dementia, and age-gender-matched healthy volunteers provided blood samples for routine and relevant biochemical examination, including the estimation of serum 25(OH) Vitamin D by Chemiluminescence Immuno Assay (CLIA). In addition, appropriate statistical methods were applied to analyse the results. Results: Overall, ninety percent of participants had low serum 25(OH)Vitamin D, defined as 25(OH)D < 20mg/ml. Hypovitaminosis D was associated with early and late-stage dementia and was statistically significant. Only five individuals were found to have sufficient 25 (OH) Vitamin D. Conclusion: The mean vitamin D level of demented patients was significantly lower compared to the control population. Our observations provide an association between Vitamin D deficiency and dementia and provides a background of longitudinal prospective study in future to show cause and effect relationship between dementia and hypovitaminosis D.https://www.nepjol.info/index.php/AJMS/article/view/48716dementia/major neurocognitive disorder; 25 (oh) vitamin d; mini-mental state examination; cross-sectional study |
| spellingShingle | Amar Kumar Misra Annesh Bhattacharjee Joydeep Mukherjee Sanjay Kumar Bijendra Mohanty Relationship of low serum 25 (OH) Vitamin D and dementia – A cross-sectional observational study from a neurology teaching hospital in East India: Relationship of low serum 25 (OH) Vitamin D and dementia in East India Asian Journal of Medical Sciences dementia/major neurocognitive disorder; 25 (oh) vitamin d; mini-mental state examination; cross-sectional study |
| title | Relationship of low serum 25 (OH) Vitamin D and dementia – A cross-sectional observational study from a neurology teaching hospital in East India: Relationship of low serum 25 (OH) Vitamin D and dementia in East India |
| title_full | Relationship of low serum 25 (OH) Vitamin D and dementia – A cross-sectional observational study from a neurology teaching hospital in East India: Relationship of low serum 25 (OH) Vitamin D and dementia in East India |
| title_fullStr | Relationship of low serum 25 (OH) Vitamin D and dementia – A cross-sectional observational study from a neurology teaching hospital in East India: Relationship of low serum 25 (OH) Vitamin D and dementia in East India |
| title_full_unstemmed | Relationship of low serum 25 (OH) Vitamin D and dementia – A cross-sectional observational study from a neurology teaching hospital in East India: Relationship of low serum 25 (OH) Vitamin D and dementia in East India |
| title_short | Relationship of low serum 25 (OH) Vitamin D and dementia – A cross-sectional observational study from a neurology teaching hospital in East India: Relationship of low serum 25 (OH) Vitamin D and dementia in East India |
| title_sort | relationship of low serum 25 oh vitamin d and dementia a cross sectional observational study from a neurology teaching hospital in east india relationship of low serum 25 oh vitamin d and dementia in east india |
| topic | dementia/major neurocognitive disorder; 25 (oh) vitamin d; mini-mental state examination; cross-sectional study |
| url | https://www.nepjol.info/index.php/AJMS/article/view/48716 |
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