The importance of D-dimer test in the follow up of patients with deep venous thrombosis
INTRODUCTION: Although deep venous thrombosis (DVT) is a treatable disease, it has a strong tendency to recur leading to serious complications such as pulmonary embolism and post-thrombotic syndrome. D-dimer testing one month after the completion of anticoagulant therapy may give an idea about the r...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Van Yuzuncu Yil University, School of Medicine
2018-07-01
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| Series: | Van Tıp Dergisi |
| Subjects: | |
| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=vtd&un=VTD-65487 |
| _version_ | 1797426169430147072 |
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| author | Meral Ekim Hasan Ekim |
| author_facet | Meral Ekim Hasan Ekim |
| author_sort | Meral Ekim |
| collection | DOAJ |
| description | INTRODUCTION: Although deep venous thrombosis (DVT) is a treatable disease, it has a strong tendency to recur leading to serious complications such as pulmonary embolism and post-thrombotic syndrome. D-dimer testing one month after the completion of anticoagulant therapy may give an idea about the risk of recurrence of disease. The aim of this study was to investigate the predictive value of D-dimer testing for recurrent events after withdrawal of coumadin therapy in patients with DVT. METHODS: This study included 70 patients with unprovoked DVT. The diagnosis of DVT was confirmed by venous Doppler ultrasonography. All patients underwent D-dimer testing approximately one month after coumadin withdrawal and they were followed 18 months. RESULTS: There were 36 male and 34 female patients with age range 32-76 years and mean age 54.3+-13.2 years. Twenty one (30%) patients had positive D-dimer testing. While 10 (20.4%) of the 49 patients with negative D-dimer testing had residual venous obstruction (RVO), 12 (57.4%) of the 21 patients with positive D-dimer testing had RVO. In 12 patients with positive D-dimer testing and RVO, duration of coumadin therapy was prolonged for 6 months. In the remaining 58 patients, DVT recurred in 8 (%13,8) patients, of whom one was found to be homozygous FVL polymorphism. DISCUSSION AND CONCLUSION: D-dimer testing should be useful to predict recurrent events one month after the discontinuing of coumadin therapy in patients with DVT. Resumption of anticoagulation therapy may be useful in patients with positive D-dimer testing. However, other clinical conditions affecting the D-dimer levels should be taken into consideration. |
| first_indexed | 2024-03-09T08:26:25Z |
| format | Article |
| id | doaj.art-2a846a6ce2c648d3838c63122a0eff6b |
| institution | Directory Open Access Journal |
| issn | 2587-0351 |
| language | English |
| last_indexed | 2024-03-09T08:26:25Z |
| publishDate | 2018-07-01 |
| publisher | Van Yuzuncu Yil University, School of Medicine |
| record_format | Article |
| series | Van Tıp Dergisi |
| spelling | doaj.art-2a846a6ce2c648d3838c63122a0eff6b2023-12-02T21:08:27ZengVan Yuzuncu Yil University, School of MedicineVan Tıp Dergisi2587-03512018-07-0125330731110.5505/vtd.2018.65487VTD-65487The importance of D-dimer test in the follow up of patients with deep venous thrombosisMeral Ekim0Hasan Ekim1Bozok University School of Health, YozgatBozok University School of Medicine, Department of Cardiovascular Surgery, YozgatINTRODUCTION: Although deep venous thrombosis (DVT) is a treatable disease, it has a strong tendency to recur leading to serious complications such as pulmonary embolism and post-thrombotic syndrome. D-dimer testing one month after the completion of anticoagulant therapy may give an idea about the risk of recurrence of disease. The aim of this study was to investigate the predictive value of D-dimer testing for recurrent events after withdrawal of coumadin therapy in patients with DVT. METHODS: This study included 70 patients with unprovoked DVT. The diagnosis of DVT was confirmed by venous Doppler ultrasonography. All patients underwent D-dimer testing approximately one month after coumadin withdrawal and they were followed 18 months. RESULTS: There were 36 male and 34 female patients with age range 32-76 years and mean age 54.3+-13.2 years. Twenty one (30%) patients had positive D-dimer testing. While 10 (20.4%) of the 49 patients with negative D-dimer testing had residual venous obstruction (RVO), 12 (57.4%) of the 21 patients with positive D-dimer testing had RVO. In 12 patients with positive D-dimer testing and RVO, duration of coumadin therapy was prolonged for 6 months. In the remaining 58 patients, DVT recurred in 8 (%13,8) patients, of whom one was found to be homozygous FVL polymorphism. DISCUSSION AND CONCLUSION: D-dimer testing should be useful to predict recurrent events one month after the discontinuing of coumadin therapy in patients with DVT. Resumption of anticoagulation therapy may be useful in patients with positive D-dimer testing. However, other clinical conditions affecting the D-dimer levels should be taken into consideration.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=vtd&un=VTD-65487d-dimercoumadinanticoagulationvenous thrombosis |
| spellingShingle | Meral Ekim Hasan Ekim The importance of D-dimer test in the follow up of patients with deep venous thrombosis Van Tıp Dergisi d-dimer coumadin anticoagulation venous thrombosis |
| title | The importance of D-dimer test in the follow up of patients with deep venous thrombosis |
| title_full | The importance of D-dimer test in the follow up of patients with deep venous thrombosis |
| title_fullStr | The importance of D-dimer test in the follow up of patients with deep venous thrombosis |
| title_full_unstemmed | The importance of D-dimer test in the follow up of patients with deep venous thrombosis |
| title_short | The importance of D-dimer test in the follow up of patients with deep venous thrombosis |
| title_sort | importance of d dimer test in the follow up of patients with deep venous thrombosis |
| topic | d-dimer coumadin anticoagulation venous thrombosis |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=vtd&un=VTD-65487 |
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