FtH-Mediated ROS Dysregulation Promotes CXCL12/CXCR4 Axis Activation and EMT-Like Trans-Differentiation in Erythroleukemia K562 Cells

FtH-Mediated ROS Dysregulation Promotes CXCL12/CXCR4 Axis Activation and EMT-Like Trans-Differentiation in Erythroleukemia K562 Cells

The cell-microenvironment communication is essential for homing of hematopoietic stem cells in stromal niches. Recent evidences support the involvement of epithelial-to-mesenchymal (EMT) process in hematopoietic stem cell homeostasis as well as in leukemia cells invasiveness and migration capability...

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Main Authors: Roberta Chirillo, Ilenia Aversa, Anna Di Vito, Alessandro Salatino, Anna Martina Battaglia, Alessandro Sacco, Maddalena Adriana Di Sanzo, Maria Concetta Faniello, Barbara Quaresima, Camillo Palmieri, Flavia Biamonte, Francesco Costanzo
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Oncology
Subjects:
ferritin heavy chain
ROS
CXCR4
EMT
NF-κB
leukemia
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00698/full

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