Diffusion tensor MR imaging evaluation in children with developmental delay
Context: Developmental delay (DD) has a significant detrimental effect on the child's quality of life. The critical time of diagnosis has a significant impact in preventing the decreased quality of life that the children with DD face, for which magnetic resonance imaging (MRI) with its new imag...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Medical Journal of Dr. D.Y. Patil Vidyapeeth |
| Subjects: | |
| Online Access: | http://www.mjdrdypv.org/article.asp?issn=2589-8302;year=2023;volume=16;issue=8;spage=200;epage=208;aulast=Krishnarjun |
| _version_ | 1827300185269600256 |
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| author | Muralinath Krishnarjun Varsha P Rangankar Sameeh Uz Zaman |
| author_facet | Muralinath Krishnarjun Varsha P Rangankar Sameeh Uz Zaman |
| author_sort | Muralinath Krishnarjun |
| collection | DOAJ |
| description | Context: Developmental delay (DD) has a significant detrimental effect on the child's quality of life. The critical time of diagnosis has a significant impact in preventing the decreased quality of life that the children with DD face, for which magnetic resonance imaging (MRI) with its new imaging techniques plays a pivotal role. Diffusion tensor imaging (DTI), a MRI technique, identifies microscopic features that are thought to be precursors to the ultimate stage of macroscopic tissue atrophy. Objectives: Spectrum of abnormal MRI brain findings was characterized, and role of DTI was evaluated in children with DD. Methods: Observational, descriptive study was performed on 80 children. Fifty cases of DD between the age of 1 month and 16 years, and 30 normal age-matched controls, underwent brain MRI with DTI for structural assessment of brain with measurement of fractional anisotropy (FA) of white matter tracts. “One sample t test” determined whether statistical significance existed between mean FA values of cases and controls. Results: Spectrum of hypoxic-ischemic insult and white matter abnormalities were the common findings seen in 21 (42%) and 19 (38%) children, respectively, amongst cases. On DTI, reduced FA was observed in white matter tracts of 24 (48%) children, most commonly in the corpus callosum of 13 (26%) children. Abnormal FA values in certain white matter tracts were observed in 6 (40%) out of 15 children with normal MRI brain. Conclusion: DTI exhibited the ability to pick up white matter tract abnormalities in the form of reduced FA values in children with DD, including some who showed structurally normal MRI. |
| first_indexed | 2024-04-24T15:48:56Z |
| format | Article |
| id | doaj.art-2a8815f483d44a679b2b9de9a67f37c7 |
| institution | Directory Open Access Journal |
| issn | 2589-8302 2589-8310 |
| language | English |
| last_indexed | 2024-04-24T15:48:56Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Medical Journal of Dr. D.Y. Patil Vidyapeeth |
| spelling | doaj.art-2a8815f483d44a679b2b9de9a67f37c72024-04-01T13:01:51ZengWolters Kluwer Medknow PublicationsMedical Journal of Dr. D.Y. Patil Vidyapeeth2589-83022589-83102023-01-0116820020810.4103/mjdrdypu.mjdrdypu_100_22Diffusion tensor MR imaging evaluation in children with developmental delayMuralinath KrishnarjunVarsha P RangankarSameeh Uz ZamanContext: Developmental delay (DD) has a significant detrimental effect on the child's quality of life. The critical time of diagnosis has a significant impact in preventing the decreased quality of life that the children with DD face, for which magnetic resonance imaging (MRI) with its new imaging techniques plays a pivotal role. Diffusion tensor imaging (DTI), a MRI technique, identifies microscopic features that are thought to be precursors to the ultimate stage of macroscopic tissue atrophy. Objectives: Spectrum of abnormal MRI brain findings was characterized, and role of DTI was evaluated in children with DD. Methods: Observational, descriptive study was performed on 80 children. Fifty cases of DD between the age of 1 month and 16 years, and 30 normal age-matched controls, underwent brain MRI with DTI for structural assessment of brain with measurement of fractional anisotropy (FA) of white matter tracts. “One sample t test” determined whether statistical significance existed between mean FA values of cases and controls. Results: Spectrum of hypoxic-ischemic insult and white matter abnormalities were the common findings seen in 21 (42%) and 19 (38%) children, respectively, amongst cases. On DTI, reduced FA was observed in white matter tracts of 24 (48%) children, most commonly in the corpus callosum of 13 (26%) children. Abnormal FA values in certain white matter tracts were observed in 6 (40%) out of 15 children with normal MRI brain. Conclusion: DTI exhibited the ability to pick up white matter tract abnormalities in the form of reduced FA values in children with DD, including some who showed structurally normal MRI.http://www.mjdrdypv.org/article.asp?issn=2589-8302;year=2023;volume=16;issue=8;spage=200;epage=208;aulast=Krishnarjuncorpus callosumdtifractional anisotropyhypoxic-ischemic insultwhite matter tracts |
| spellingShingle | Muralinath Krishnarjun Varsha P Rangankar Sameeh Uz Zaman Diffusion tensor MR imaging evaluation in children with developmental delay Medical Journal of Dr. D.Y. Patil Vidyapeeth corpus callosum dti fractional anisotropy hypoxic-ischemic insult white matter tracts |
| title | Diffusion tensor MR imaging evaluation in children with developmental delay |
| title_full | Diffusion tensor MR imaging evaluation in children with developmental delay |
| title_fullStr | Diffusion tensor MR imaging evaluation in children with developmental delay |
| title_full_unstemmed | Diffusion tensor MR imaging evaluation in children with developmental delay |
| title_short | Diffusion tensor MR imaging evaluation in children with developmental delay |
| title_sort | diffusion tensor mr imaging evaluation in children with developmental delay |
| topic | corpus callosum dti fractional anisotropy hypoxic-ischemic insult white matter tracts |
| url | http://www.mjdrdypv.org/article.asp?issn=2589-8302;year=2023;volume=16;issue=8;spage=200;epage=208;aulast=Krishnarjun |
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