Reward learning improves social signal processing in autism model mice
Summary: Social and reward signal processing and their association are critical elements of social motivation. Despite the use of reward learning to improve the social interactions of patients with autism spectrum disorder (ASD), the underlying neural mechanisms are unknown. Here, we found different...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-10-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124723012408 |
| _version_ | 1797660292578017280 |
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| author | Joowon Kim Min Whan Jung Doyun Lee |
| author_facet | Joowon Kim Min Whan Jung Doyun Lee |
| author_sort | Joowon Kim |
| collection | DOAJ |
| description | Summary: Social and reward signal processing and their association are critical elements of social motivation. Despite the use of reward learning to improve the social interactions of patients with autism spectrum disorder (ASD), the underlying neural mechanisms are unknown. Here, we found different yet conjunct neuronal representations of social and reward signals in the mouse medial prefrontal cortex (mPFC). We also found that social signal processing is selectively disrupted, whereas reward signal processing is intact in the mPFC of Shank2-knockout mice, a mouse model of ASD. Furthermore, reward learning not only allows Shank2-knockout mice to associate social stimuli with reward availability, but it also rescues the impaired social signal processing. These findings provide insights into the neural basis for the therapeutic use of reward learning in ASD. |
| first_indexed | 2024-03-11T18:28:40Z |
| format | Article |
| id | doaj.art-2a89c9f174d74d6282412b67db372a59 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-03-11T18:28:40Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-2a89c9f174d74d6282412b67db372a592023-10-13T13:53:24ZengElsevierCell Reports2211-12472023-10-014210113228Reward learning improves social signal processing in autism model miceJoowon Kim0Min Whan Jung1Doyun Lee2Center for Cognition and Sociality, Institute for Basic Science, Daejeon 34126, Korea; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, KoreaGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Korea; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, Korea; Center for Synaptic Brain Dysfunction, Institute for Basic Science, Daejeon 34141, Korea; Corresponding authorCenter for Cognition and Sociality, Institute for Basic Science, Daejeon 34126, Korea; Corresponding authorSummary: Social and reward signal processing and their association are critical elements of social motivation. Despite the use of reward learning to improve the social interactions of patients with autism spectrum disorder (ASD), the underlying neural mechanisms are unknown. Here, we found different yet conjunct neuronal representations of social and reward signals in the mouse medial prefrontal cortex (mPFC). We also found that social signal processing is selectively disrupted, whereas reward signal processing is intact in the mPFC of Shank2-knockout mice, a mouse model of ASD. Furthermore, reward learning not only allows Shank2-knockout mice to associate social stimuli with reward availability, but it also rescues the impaired social signal processing. These findings provide insights into the neural basis for the therapeutic use of reward learning in ASD.http://www.sciencedirect.com/science/article/pii/S2211124723012408CP: Neuroscience |
| spellingShingle | Joowon Kim Min Whan Jung Doyun Lee Reward learning improves social signal processing in autism model mice Cell Reports CP: Neuroscience |
| title | Reward learning improves social signal processing in autism model mice |
| title_full | Reward learning improves social signal processing in autism model mice |
| title_fullStr | Reward learning improves social signal processing in autism model mice |
| title_full_unstemmed | Reward learning improves social signal processing in autism model mice |
| title_short | Reward learning improves social signal processing in autism model mice |
| title_sort | reward learning improves social signal processing in autism model mice |
| topic | CP: Neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2211124723012408 |
| work_keys_str_mv | AT joowonkim rewardlearningimprovessocialsignalprocessinginautismmodelmice AT minwhanjung rewardlearningimprovessocialsignalprocessinginautismmodelmice AT doyunlee rewardlearningimprovessocialsignalprocessinginautismmodelmice |