Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor
Here, using cryo-electron microscopy and solution NMR, the authors reveal the structural and dynamic mechanisms underlying the signaling versatility of a muscarinic receptor regulated by orthosteric and allosteric ligands.
Bibliographic Details
| Main Authors: |
Jun Xu,
Qinggong Wang,
Harald Hübner,
Yunfei Hu,
Xiaogang Niu,
Haoqing Wang,
Shoji Maeda,
Asuka Inoue,
Yuyong Tao,
Peter Gmeiner,
Yang Du,
Changwen Jin,
Brian K. Kobilka |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2023-01-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-022-35726-z
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