Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor
Here, using cryo-electron microscopy and solution NMR, the authors reveal the structural and dynamic mechanisms underlying the signaling versatility of a muscarinic receptor regulated by orthosteric and allosteric ligands.
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-35726-z |
| _version_ | 1811175795758989312 |
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| author | Jun Xu Qinggong Wang Harald Hübner Yunfei Hu Xiaogang Niu Haoqing Wang Shoji Maeda Asuka Inoue Yuyong Tao Peter Gmeiner Yang Du Changwen Jin Brian K. Kobilka |
| author_facet | Jun Xu Qinggong Wang Harald Hübner Yunfei Hu Xiaogang Niu Haoqing Wang Shoji Maeda Asuka Inoue Yuyong Tao Peter Gmeiner Yang Du Changwen Jin Brian K. Kobilka |
| author_sort | Jun Xu |
| collection | DOAJ |
| description | Here, using cryo-electron microscopy and solution NMR, the authors reveal the structural and dynamic mechanisms underlying the signaling versatility of a muscarinic receptor regulated by orthosteric and allosteric ligands. |
| first_indexed | 2024-04-10T19:41:41Z |
| format | Article |
| id | doaj.art-2a8a4fc6bad2451e913c4050e4dba574 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-10T19:41:41Z |
| publishDate | 2023-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-2a8a4fc6bad2451e913c4050e4dba5742023-01-29T12:16:04ZengNature PortfolioNature Communications2041-17232023-01-0114111610.1038/s41467-022-35726-zStructural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptorJun Xu0Qinggong Wang1Harald Hübner2Yunfei Hu3Xiaogang Niu4Haoqing Wang5Shoji Maeda6Asuka Inoue7Yuyong Tao8Peter Gmeiner9Yang Du10Changwen Jin11Brian K. Kobilka12Department of Molecular and Cellular Physiology, Stanford University School of MedicineKobilka Institute of Innovative Drug Discovery, School of Life and Health Sciences, Chinese University of Hong KongDepartment of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander UniversityBeijing Nuclear Magnetic Resonance Center, College of Chemistry and Molecular Engineering, Peking UniversityBeijing Nuclear Magnetic Resonance Center, College of Chemistry and Molecular Engineering, Peking UniversityDepartment of Molecular and Cellular Physiology, Stanford University School of MedicineDepartment of Molecular and Cellular Physiology, Stanford University School of MedicineGraduate School of Pharmaceutical Sciences, Tohoku UniversityDivision of Life Sciences and Medicine, University of Science and Technology of ChinaDepartment of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander UniversityKobilka Institute of Innovative Drug Discovery, School of Life and Health Sciences, Chinese University of Hong KongBeijing Nuclear Magnetic Resonance Center, College of Chemistry and Molecular Engineering, Peking UniversityDepartment of Molecular and Cellular Physiology, Stanford University School of MedicineHere, using cryo-electron microscopy and solution NMR, the authors reveal the structural and dynamic mechanisms underlying the signaling versatility of a muscarinic receptor regulated by orthosteric and allosteric ligands.https://doi.org/10.1038/s41467-022-35726-z |
| spellingShingle | Jun Xu Qinggong Wang Harald Hübner Yunfei Hu Xiaogang Niu Haoqing Wang Shoji Maeda Asuka Inoue Yuyong Tao Peter Gmeiner Yang Du Changwen Jin Brian K. Kobilka Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor Nature Communications |
| title | Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor |
| title_full | Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor |
| title_fullStr | Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor |
| title_full_unstemmed | Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor |
| title_short | Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor |
| title_sort | structural and dynamic insights into supra physiological activation and allosteric modulation of a muscarinic acetylcholine receptor |
| url | https://doi.org/10.1038/s41467-022-35726-z |
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