The biosynthesis of zinc oxide nanoparticles using aqueous leaf extracts of Cnidoscolus aconitifolius and their biological activities
ABSTRACTThis study aims to biosynthesize zinc oxide nanoparticles using aqueous leaf extracts of Cnidoscolus aconitifolius and investigate their biological activities. UV–Vis Spectroscopy, FT-IR, SEM and TEM were used for characterization. The antioxidant properties were determined using H2O2, NO, A...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2023-01-01
|
| Series: | Green Chemistry Letters and Reviews |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/17518253.2023.2169591 |
| _version_ | 1797450016086818816 |
|---|---|
| author | Reuben Samson Dangana Reama Chinedu George Femi Kayode Agboola |
| author_facet | Reuben Samson Dangana Reama Chinedu George Femi Kayode Agboola |
| author_sort | Reuben Samson Dangana |
| collection | DOAJ |
| description | ABSTRACTThis study aims to biosynthesize zinc oxide nanoparticles using aqueous leaf extracts of Cnidoscolus aconitifolius and investigate their biological activities. UV–Vis Spectroscopy, FT-IR, SEM and TEM were used for characterization. The antioxidant properties were determined using H2O2, NO, ABTS, FRAP and DPPH scavenging assays. For anti-inflammatory activities, membrane stabilization, albumin denaturation and proteinase inhibitory activity were assayed. The antibacterial effect was tested using well diffusion method. Statistical analyses were done using ANOVA. Synthesized nanoparticles showed an intensity peak at 378 nm in UV–Vis Spectroscopy. FT-IR shows the presence of O-H stretching, C = C bending, O-H bending and C–N stretching functional groups of the stabilizing action of the plant extract on the surface of the nanoparticles. NPs were shown to be spherical by SEM analysis, and the sizes were 100 nm by TEM analysis. The antioxidant properties of ZnO NPs compared to ascorbic acid standard showed significant antioxidant potential in H2O2, NO, ABTS, FRAP and DPPH scavenging assays. ZnO NPs showed excellent anti-inflammatory activity with the synthesized ZnO NPs performing better in membrane stabilization. Clinical pathogens were inhibited by ZnO NPs when compared with Cefuroxime, a standard drug. These efficient biological activities could be utilized in several biological applications. |
| first_indexed | 2024-03-09T14:34:24Z |
| format | Article |
| id | doaj.art-2a8bcb1406a34d6abbbc094766b35c67 |
| institution | Directory Open Access Journal |
| issn | 1751-8253 1751-7192 |
| language | English |
| last_indexed | 2024-03-09T14:34:24Z |
| publishDate | 2023-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Green Chemistry Letters and Reviews |
| spelling | doaj.art-2a8bcb1406a34d6abbbc094766b35c672023-11-27T14:52:10ZengTaylor & Francis GroupGreen Chemistry Letters and Reviews1751-82531751-71922023-01-0116110.1080/17518253.2023.2169591The biosynthesis of zinc oxide nanoparticles using aqueous leaf extracts of Cnidoscolus aconitifolius and their biological activitiesReuben Samson Dangana0Reama Chinedu George1Femi Kayode Agboola2Department of Biochemistry and Molecular Biology Obafemi Awolowo University Ile-Ife, NigeriaDepartment of Chemistry, Obafemi Awolowo University, Ile Ife, NigeriaDepartment of Chemistry, Obafemi Awolowo University, Ile Ife, NigeriaABSTRACTThis study aims to biosynthesize zinc oxide nanoparticles using aqueous leaf extracts of Cnidoscolus aconitifolius and investigate their biological activities. UV–Vis Spectroscopy, FT-IR, SEM and TEM were used for characterization. The antioxidant properties were determined using H2O2, NO, ABTS, FRAP and DPPH scavenging assays. For anti-inflammatory activities, membrane stabilization, albumin denaturation and proteinase inhibitory activity were assayed. The antibacterial effect was tested using well diffusion method. Statistical analyses were done using ANOVA. Synthesized nanoparticles showed an intensity peak at 378 nm in UV–Vis Spectroscopy. FT-IR shows the presence of O-H stretching, C = C bending, O-H bending and C–N stretching functional groups of the stabilizing action of the plant extract on the surface of the nanoparticles. NPs were shown to be spherical by SEM analysis, and the sizes were 100 nm by TEM analysis. The antioxidant properties of ZnO NPs compared to ascorbic acid standard showed significant antioxidant potential in H2O2, NO, ABTS, FRAP and DPPH scavenging assays. ZnO NPs showed excellent anti-inflammatory activity with the synthesized ZnO NPs performing better in membrane stabilization. Clinical pathogens were inhibited by ZnO NPs when compared with Cefuroxime, a standard drug. These efficient biological activities could be utilized in several biological applications.https://www.tandfonline.com/doi/10.1080/17518253.2023.2169591Nanoparticleszinc oxidebiosynthesisantioxidantanti-inflammatory |
| spellingShingle | Reuben Samson Dangana Reama Chinedu George Femi Kayode Agboola The biosynthesis of zinc oxide nanoparticles using aqueous leaf extracts of Cnidoscolus aconitifolius and their biological activities Green Chemistry Letters and Reviews Nanoparticles zinc oxide biosynthesis antioxidant anti-inflammatory |
| title | The biosynthesis of zinc oxide nanoparticles using aqueous leaf extracts of Cnidoscolus aconitifolius and their biological activities |
| title_full | The biosynthesis of zinc oxide nanoparticles using aqueous leaf extracts of Cnidoscolus aconitifolius and their biological activities |
| title_fullStr | The biosynthesis of zinc oxide nanoparticles using aqueous leaf extracts of Cnidoscolus aconitifolius and their biological activities |
| title_full_unstemmed | The biosynthesis of zinc oxide nanoparticles using aqueous leaf extracts of Cnidoscolus aconitifolius and their biological activities |
| title_short | The biosynthesis of zinc oxide nanoparticles using aqueous leaf extracts of Cnidoscolus aconitifolius and their biological activities |
| title_sort | biosynthesis of zinc oxide nanoparticles using aqueous leaf extracts of cnidoscolus aconitifolius and their biological activities |
| topic | Nanoparticles zinc oxide biosynthesis antioxidant anti-inflammatory |
| url | https://www.tandfonline.com/doi/10.1080/17518253.2023.2169591 |
| work_keys_str_mv | AT reubensamsondangana thebiosynthesisofzincoxidenanoparticlesusingaqueousleafextractsofcnidoscolusaconitifoliusandtheirbiologicalactivities AT reamachinedugeorge thebiosynthesisofzincoxidenanoparticlesusingaqueousleafextractsofcnidoscolusaconitifoliusandtheirbiologicalactivities AT femikayodeagboola thebiosynthesisofzincoxidenanoparticlesusingaqueousleafextractsofcnidoscolusaconitifoliusandtheirbiologicalactivities AT reubensamsondangana biosynthesisofzincoxidenanoparticlesusingaqueousleafextractsofcnidoscolusaconitifoliusandtheirbiologicalactivities AT reamachinedugeorge biosynthesisofzincoxidenanoparticlesusingaqueousleafextractsofcnidoscolusaconitifoliusandtheirbiologicalactivities AT femikayodeagboola biosynthesisofzincoxidenanoparticlesusingaqueousleafextractsofcnidoscolusaconitifoliusandtheirbiologicalactivities |