Role of mitochondria, oxidative stress and the response to antioxidants in myalgic encephalomyelitis/chronic fatigue syndrome: A possible approach to SARS-CoV-2 ‘long-haulers’?
A significant number of SARS-CoV-2 (COVID-19) pandemic patients have developed chronic symptoms lasting weeks or months which are very similar to those described for myalgic encephalomyelitis/chronic fatigue syndrome. This study reviews the current literature and understanding of the role that mitoc...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-03-01
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| Series: | Chronic Diseases and Translational Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2095882X20300839 |
| _version_ | 1811327860821983232 |
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| author | Emily Wood Katherine H. Hall Warren Tate |
| author_facet | Emily Wood Katherine H. Hall Warren Tate |
| author_sort | Emily Wood |
| collection | DOAJ |
| description | A significant number of SARS-CoV-2 (COVID-19) pandemic patients have developed chronic symptoms lasting weeks or months which are very similar to those described for myalgic encephalomyelitis/chronic fatigue syndrome. This study reviews the current literature and understanding of the role that mitochondria, oxidative stress and antioxidants may play in the understanding of the pathophysiology and treatment of chronic fatigue. It describes what is known about the dysfunctional pathways which can develop in mitochondria and their relationship to chronic fatigue. It also reviews what is known about oxidative stress and how this can be related to the pathophysiology of fatigue, as well as examining the potential for specific therapy directed at mitochondria for the treatment of chronic fatigue in the form of antioxidants. This study identifies areas which require urgent, further research in order to fully elucidate the clinical and therapeutic potential of these approaches. |
| first_indexed | 2024-04-13T15:15:20Z |
| format | Article |
| id | doaj.art-2a8c1d4d6bfb4492997ea025186013f3 |
| institution | Directory Open Access Journal |
| issn | 2095-882X |
| language | English |
| last_indexed | 2024-04-13T15:15:20Z |
| publishDate | 2021-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Chronic Diseases and Translational Medicine |
| spelling | doaj.art-2a8c1d4d6bfb4492997ea025186013f32022-12-22T02:41:52ZengWileyChronic Diseases and Translational Medicine2095-882X2021-03-01711426Role of mitochondria, oxidative stress and the response to antioxidants in myalgic encephalomyelitis/chronic fatigue syndrome: A possible approach to SARS-CoV-2 ‘long-haulers’?Emily Wood0Katherine H. Hall1Warren Tate2Department of Biochemistry, Health Sciences Division, University of Otago, Dunedin, New ZealandDepartment of General Practice and Rural Health, Otago Medical School – Dunedin Campus, University of Otago, Dunedin, New Zealand; Corresponding author.Department of Biochemistry, Health Sciences Division, University of Otago, Dunedin, New ZealandA significant number of SARS-CoV-2 (COVID-19) pandemic patients have developed chronic symptoms lasting weeks or months which are very similar to those described for myalgic encephalomyelitis/chronic fatigue syndrome. This study reviews the current literature and understanding of the role that mitochondria, oxidative stress and antioxidants may play in the understanding of the pathophysiology and treatment of chronic fatigue. It describes what is known about the dysfunctional pathways which can develop in mitochondria and their relationship to chronic fatigue. It also reviews what is known about oxidative stress and how this can be related to the pathophysiology of fatigue, as well as examining the potential for specific therapy directed at mitochondria for the treatment of chronic fatigue in the form of antioxidants. This study identifies areas which require urgent, further research in order to fully elucidate the clinical and therapeutic potential of these approaches.http://www.sciencedirect.com/science/article/pii/S2095882X20300839Chronic fatigue syndromeMitochondriaOxidative stressAntioxidantsSARS-CoV-2 |
| spellingShingle | Emily Wood Katherine H. Hall Warren Tate Role of mitochondria, oxidative stress and the response to antioxidants in myalgic encephalomyelitis/chronic fatigue syndrome: A possible approach to SARS-CoV-2 ‘long-haulers’? Chronic Diseases and Translational Medicine Chronic fatigue syndrome Mitochondria Oxidative stress Antioxidants SARS-CoV-2 |
| title | Role of mitochondria, oxidative stress and the response to antioxidants in myalgic encephalomyelitis/chronic fatigue syndrome: A possible approach to SARS-CoV-2 ‘long-haulers’? |
| title_full | Role of mitochondria, oxidative stress and the response to antioxidants in myalgic encephalomyelitis/chronic fatigue syndrome: A possible approach to SARS-CoV-2 ‘long-haulers’? |
| title_fullStr | Role of mitochondria, oxidative stress and the response to antioxidants in myalgic encephalomyelitis/chronic fatigue syndrome: A possible approach to SARS-CoV-2 ‘long-haulers’? |
| title_full_unstemmed | Role of mitochondria, oxidative stress and the response to antioxidants in myalgic encephalomyelitis/chronic fatigue syndrome: A possible approach to SARS-CoV-2 ‘long-haulers’? |
| title_short | Role of mitochondria, oxidative stress and the response to antioxidants in myalgic encephalomyelitis/chronic fatigue syndrome: A possible approach to SARS-CoV-2 ‘long-haulers’? |
| title_sort | role of mitochondria oxidative stress and the response to antioxidants in myalgic encephalomyelitis chronic fatigue syndrome a possible approach to sars cov 2 long haulers |
| topic | Chronic fatigue syndrome Mitochondria Oxidative stress Antioxidants SARS-CoV-2 |
| url | http://www.sciencedirect.com/science/article/pii/S2095882X20300839 |
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