Inclusion of a dual signal sequence enhances the immunogenicity of a novel viral vectored vaccine against the capsular group B meningococcus

Inclusion of a dual signal sequence enhances the immunogenicity of a novel viral vectored vaccine against the capsular group B meningococcus

Abstract Background Disease caused by the capsular group B meningococcus (MenB) is the leading cause of infectious death in UK infants. A novel adenovirus-based vaccine encoding the MenB factor H binding protein (fHbp) with an N-terminal dual signal sequence induces high titres of protective antibod...

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Bibliographic Details
Main Authors: Dylan Sheerin, Christina Dold, Laura Silva-Reyes, Aline Linder, Andrew J. Pollard, Christine S. Rollier
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Cell & Bioscience
Subjects:
Meningococcal disease
Viral vector vaccines
Signal sequence
Transgene
Expression kinetics
Online Access:https://doi.org/10.1186/s13578-022-00809-3

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