A Generic Approach for Miniaturized Unbiased High-Throughput Screens of Bispecific Antibodies and Biparatopic Antibody–Drug Conjugates

A Generic Approach for Miniaturized Unbiased High-Throughput Screens of Bispecific Antibodies and Biparatopic Antibody–Drug Conjugates

The toolbox of modern antibody engineering allows the design of versatile novel functionalities exceeding nature’s repertoire. Many bispecific antibodies comprise heterodimeric Fc portions recently validated through the approval of several bispecific biotherapeutics. While heterodimerization methodo...

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Bibliographic Details
Main Authors: Nadine Barron, Stephan Dickgiesser, Markus Fleischer, Angelika-Nicole Bachmann, Daniel Klewinghaus, Jens Hannewald, Elke Ciesielski, Ilja Kusters, Til Hammann, Volker Krause, Sebastian Winfried Fuchs, Vanessa Siegmund, Alec W. Gross, Dirk Mueller-Pompalla, Simon Krah, Stefan Zielonka, Achim Doerner
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:International Journal of Molecular Sciences
Subjects:
DuoBody
bispecific antibody
unbiased screening
automation
miniaturization
Online Access:https://www.mdpi.com/1422-0067/25/4/2097

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