C16 Peptide Promotes Vascular Growth and Reduces Inflammation in a Neuromyelitis Optica Model

C16 Peptide Promotes Vascular Growth and Reduces Inflammation in a Neuromyelitis Optica Model

The goal of this study was to elucidate the mechanism of action of C16, a laminin-1 peptide that competes with αvβ3 for integrin binding, in treating neuromyelitis optica (NMO). A NMO rat model was established and specific inhibitors were used to investigate the effect of Tie2 kinase, integrin, and...

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Bibliographic Details
Main Authors: Haohao Chen, Xiaoxiao Fu, Jinzhan Jiang, Shu Han
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Pharmacology
Subjects:
C16 peptide
receptor tyrosine kinase Tie2
PI3K/Akt pathways
αvβ3 integrin
neuromyelitis optica (NMO)
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01373/full

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