Glutamine addiction: an Achilles heel in esophageal cancers with dysregulation of CDK4/6

Glutamine addiction: an Achilles heel in esophageal cancers with dysregulation of CDK4/6

Understanding and overcoming resistance to cyclin-dependent kinase 4/6 (CDK4/6) inhibitors will be challenging. Recent work reveals that dysregulation of F-Box Protein 4 (FBXO4)-Cyclin D1 axis leads to mitochondrial dysfunction and drives glutamine-addiction in esophageal squamous cell carcinoma. Th...

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Bibliographic Details
Main Authors: Shuo Qie, J. Alan Diehl
Format: Article
Language:English
Published: Taylor & Francis Group 2019-07-01
Series:Molecular & Cellular Oncology
Subjects:
glutamine-addiction
cyclin d1
glutaminase
cdk4/6 inhibitor
acquired resistance
Online Access:http://dx.doi.org/10.1080/23723556.2019.1610257

Internet

http://dx.doi.org/10.1080/23723556.2019.1610257

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