Methods Favoring Homology-Directed Repair Choice in Response to CRISPR/Cas9 Induced-Double Strand Breaks

Methods Favoring Homology-Directed Repair Choice in Response to CRISPR/Cas9 Induced-Double Strand Breaks

Precise gene editing is—or will soon be—in clinical use for several diseases, and more applications are under development. The programmable nuclease Cas9, directed by a single-guide RNA (sgRNA), can introduce double-strand breaks (DSBs) in target sites of genomic DNA, which constitutes the initial s...

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Bibliographic Details
Main Authors: Han Yang, Shuling Ren, Siyuan Yu, Haifeng Pan, Tingdong Li, Shengxiang Ge, Jun Zhang, Ningshao Xia
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
gene editing
CRISPR/Cas9
HDR
NHEJ
repair pathway choice
Online Access:https://www.mdpi.com/1422-0067/21/18/6461

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