The Noncanonical Functions of Metabolites in Tumor Progression
Metabolic reprogramming has emerged as a prominent hallmark of cancer, characterized by substantial alterations in nutrient uptake and intracellular metabolic pathways. Consequently, intracellular metabolite concentrations undergo significant changes which can contribute to tumorigenesis through div...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | Metabolites |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-1989/14/3/171 |
| _version_ | 1797240050676662272 |
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| author | Siyang Wu Yijun Qi Weiwei Yang |
| author_facet | Siyang Wu Yijun Qi Weiwei Yang |
| author_sort | Siyang Wu |
| collection | DOAJ |
| description | Metabolic reprogramming has emerged as a prominent hallmark of cancer, characterized by substantial alterations in nutrient uptake and intracellular metabolic pathways. Consequently, intracellular metabolite concentrations undergo significant changes which can contribute to tumorigenesis through diverse mechanisms. Beyond their classical roles in regulating metabolic pathway flux, metabolites exhibit noncanonical functions that play a crucial role in tumor progression. In this review, we delve into the nonclassical functions of metabolites in the context of tumor progression, with a particular focus on their capacity to modulate gene expression and cell signaling. Furthermore, we discuss the potential exploitation of these nonclassical functions in the enhancement of cancer therapy. |
| first_indexed | 2024-04-24T18:01:16Z |
| format | Article |
| id | doaj.art-2a91949821be4925ae6c52cb93c1ed71 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-04-24T18:01:16Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-2a91949821be4925ae6c52cb93c1ed712024-03-27T13:54:12ZengMDPI AGMetabolites2218-19892024-03-0114317110.3390/metabo14030171The Noncanonical Functions of Metabolites in Tumor ProgressionSiyang Wu0Yijun Qi1Weiwei Yang2Key Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, ChinaKey Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, ChinaKey Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, ChinaMetabolic reprogramming has emerged as a prominent hallmark of cancer, characterized by substantial alterations in nutrient uptake and intracellular metabolic pathways. Consequently, intracellular metabolite concentrations undergo significant changes which can contribute to tumorigenesis through diverse mechanisms. Beyond their classical roles in regulating metabolic pathway flux, metabolites exhibit noncanonical functions that play a crucial role in tumor progression. In this review, we delve into the nonclassical functions of metabolites in the context of tumor progression, with a particular focus on their capacity to modulate gene expression and cell signaling. Furthermore, we discuss the potential exploitation of these nonclassical functions in the enhancement of cancer therapy.https://www.mdpi.com/2218-1989/14/3/171metabolitesnoncanonical functions of metabolitesmetabolic reprogrammingtumor progressions |
| spellingShingle | Siyang Wu Yijun Qi Weiwei Yang The Noncanonical Functions of Metabolites in Tumor Progression Metabolites metabolites noncanonical functions of metabolites metabolic reprogramming tumor progressions |
| title | The Noncanonical Functions of Metabolites in Tumor Progression |
| title_full | The Noncanonical Functions of Metabolites in Tumor Progression |
| title_fullStr | The Noncanonical Functions of Metabolites in Tumor Progression |
| title_full_unstemmed | The Noncanonical Functions of Metabolites in Tumor Progression |
| title_short | The Noncanonical Functions of Metabolites in Tumor Progression |
| title_sort | noncanonical functions of metabolites in tumor progression |
| topic | metabolites noncanonical functions of metabolites metabolic reprogramming tumor progressions |
| url | https://www.mdpi.com/2218-1989/14/3/171 |
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