Common and Rare Genetic Risk Factors Converge in Protein Interaction Networks Underlying Schizophrenia

Common and Rare Genetic Risk Factors Converge in Protein Interaction Networks Underlying Schizophrenia

Hundreds of genomic loci have been identified with the recent advances of schizophrenia in genome-wide association studies (GWAS) and sequencing studies. However, the functional interactions among those genes remain largely unknown. We developed a network-based approach to integrate multiple genetic...

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Bibliographic Details
Main Authors: Xiao Chang, Leandro de Araujo Lima, Yichuan Liu, Jin Li, Qingqin Li, Patrick M. A. Sleiman, Hakon Hakonarson
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Genetics
Subjects:
schizophrenia
GWAS
PPI Network
copy number variation (CNV)
gene modules
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2018.00434/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2018.00434/full

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