Diabetic neuropathy in combination with deficiency state
Diabetic polyneuropathy (DPN) is the most common neurological complication of diabetes mellitus. The most common type of DPN is distal symmetric, predominantly sensory, polyneuropathy. Chronic hyperglycemia plays a key role in DPN pathogenesis. It leads to accumulation of advanced glycation end prod...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Remedium Group LLC
2022-03-01
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| Series: | Медицинский совет |
| Subjects: | |
| Online Access: | https://www.med-sovet.pro/jour/article/view/6743 |
| _version_ | 1797841886787928064 |
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| author | O. E. Zinovyeva P. D. Egorov V. N. Novikov I. M. Lovchev |
| author_facet | O. E. Zinovyeva P. D. Egorov V. N. Novikov I. M. Lovchev |
| author_sort | O. E. Zinovyeva |
| collection | DOAJ |
| description | Diabetic polyneuropathy (DPN) is the most common neurological complication of diabetes mellitus. The most common type of DPN is distal symmetric, predominantly sensory, polyneuropathy. Chronic hyperglycemia plays a key role in DPN pathogenesis. It leads to accumulation of advanced glycation end products in tissues, including vasa nevrorum that supply peripheral nerves with oxygen. Thorough diagnostic approach to DPN is crucial for early detection of this condition. Early diagnosis and treatment slow DPN progression rates and leads to symptom reduction. Long-lasting metformin therapy may cause vitamin B deficiency. This article describes a comprehensive approach to the treatment of patient with type 2 diabetes and symptomatic diabetic and vitamin deficiency neuropathy. Apart from DM therapy, the patient received pathogenesis-based therapy of DPN with alpha-lipoic acid and a combination of vitamins B1, B6 and B12. Such pathogenesis-based approach has shown to decrease severity of DPN symptoms and reduce sensory ataxia. |
| first_indexed | 2024-04-09T16:39:52Z |
| format | Article |
| id | doaj.art-2a93e6b7dfef49ec9baec6cf1c3d4499 |
| institution | Directory Open Access Journal |
| issn | 2079-701X 2658-5790 |
| language | Russian |
| last_indexed | 2024-04-09T16:39:52Z |
| publishDate | 2022-03-01 |
| publisher | Remedium Group LLC |
| record_format | Article |
| series | Медицинский совет |
| spelling | doaj.art-2a93e6b7dfef49ec9baec6cf1c3d44992023-04-23T06:56:45ZrusRemedium Group LLCМедицинский совет2079-701X2658-57902022-03-0102959910.21518/2079-701X-2022-16-2-95-996063Diabetic neuropathy in combination with deficiency stateO. E. Zinovyeva0P. D. Egorov1V. N. Novikov2I. M. Lovchev3Sechenov First Moscow State Medical University (Sechenov University)Sechenov First Moscow State Medical University (Sechenov University)Sechenov First Moscow State Medical University (Sechenov University)Sechenov First Moscow State Medical University (Sechenov University)Diabetic polyneuropathy (DPN) is the most common neurological complication of diabetes mellitus. The most common type of DPN is distal symmetric, predominantly sensory, polyneuropathy. Chronic hyperglycemia plays a key role in DPN pathogenesis. It leads to accumulation of advanced glycation end products in tissues, including vasa nevrorum that supply peripheral nerves with oxygen. Thorough diagnostic approach to DPN is crucial for early detection of this condition. Early diagnosis and treatment slow DPN progression rates and leads to symptom reduction. Long-lasting metformin therapy may cause vitamin B deficiency. This article describes a comprehensive approach to the treatment of patient with type 2 diabetes and symptomatic diabetic and vitamin deficiency neuropathy. Apart from DM therapy, the patient received pathogenesis-based therapy of DPN with alpha-lipoic acid and a combination of vitamins B1, B6 and B12. Such pathogenesis-based approach has shown to decrease severity of DPN symptoms and reduce sensory ataxia.https://www.med-sovet.pro/jour/article/view/6743diabetes mellitusdiabetic polyneuropathypathogenetic treatmentalpha-lipoic acidneurotropic b vitamins |
| spellingShingle | O. E. Zinovyeva P. D. Egorov V. N. Novikov I. M. Lovchev Diabetic neuropathy in combination with deficiency state Медицинский совет diabetes mellitus diabetic polyneuropathy pathogenetic treatment alpha-lipoic acid neurotropic b vitamins |
| title | Diabetic neuropathy in combination with deficiency state |
| title_full | Diabetic neuropathy in combination with deficiency state |
| title_fullStr | Diabetic neuropathy in combination with deficiency state |
| title_full_unstemmed | Diabetic neuropathy in combination with deficiency state |
| title_short | Diabetic neuropathy in combination with deficiency state |
| title_sort | diabetic neuropathy in combination with deficiency state |
| topic | diabetes mellitus diabetic polyneuropathy pathogenetic treatment alpha-lipoic acid neurotropic b vitamins |
| url | https://www.med-sovet.pro/jour/article/view/6743 |
| work_keys_str_mv | AT oezinovyeva diabeticneuropathyincombinationwithdeficiencystate AT pdegorov diabeticneuropathyincombinationwithdeficiencystate AT vnnovikov diabeticneuropathyincombinationwithdeficiencystate AT imlovchev diabeticneuropathyincombinationwithdeficiencystate |