Systems biology of coagulation initiation: kinetics of thrombin generation in resting and activated human blood.

Systems biology of coagulation initiation: kinetics of thrombin generation in resting and activated human blood.

Blood function defines bleeding and clotting risks and dictates approaches for clinical intervention. Independent of adding exogenous tissue factor (TF), human blood treated in vitro with corn trypsin inhibitor (CTI, to block Factor XIIa) will generate thrombin after an initiation time (T(i)) of 1 t...

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Bibliographic Details
Main Authors:	Manash S Chatterjee, William S Denney, Huiyan Jing, Scott L Diamond
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2010-09-01
Series:	PLoS Computational Biology
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20941387/?tool=EBI

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