Neonatal Urinary Tract Infection: Clinical Response to Empirical Therapy versus In vitro Susceptibility at Bahrami Children’s Hospital- Neonatal Ward: 2001-2010
Urinary tract infection (UTI) is a neonatal life threatening infection which is usually treated with ampicillin plus an aminoglycoside or a third-generation cephalosporin. Recently, growing number of Escherchia coli species resistant to ampicillin and aminoglycosides have raised concerns regarding t...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tehran University of Medical Sciences
2012-05-01
|
| Series: | Acta Medica Iranica |
| Subjects: | |
| Online Access: | https://acta.tums.ac.ir/index.php/acta/article/view/3910 |
| _version_ | 1818360156760571904 |
|---|---|
| author | Peymaneh Alizadeh Taheri Behdad Navabi Mamak Shariat |
| author_facet | Peymaneh Alizadeh Taheri Behdad Navabi Mamak Shariat |
| author_sort | Peymaneh Alizadeh Taheri |
| collection | DOAJ |
| description | Urinary tract infection (UTI) is a neonatal life threatening infection which is usually treated with ampicillin plus an aminoglycoside or a third-generation cephalosporin. Recently, growing number of Escherchia coli species resistant to ampicillin and aminoglycosides have raised concerns regarding the necessity to change the empirical therapy. This motivates us to determine neonatal UTI clinical response to the used empirical antibiotics. This study was designed as a Case Series. All neonates admitted to Bahrami Children Hospital, Tehran, Iran, during 2001- 2010 with a diagnosis of UTI surveyed by simple non-random sampling. Totally, 97 cases (including 83 (85.6%) term, 8 (8.2%) post-term and 6 (6.2%) preterm neonates) with a mean age of 15.85 ± 7.05 days at admission ,average weight of 3195.57 ± 553g at birth and 3276.29 ± 599.182 g at admission were studied. Ampicillin resistance in 93 cases (95.9%), gentamicin resistance in 51 cases (52.6%) and trimethoprim- sulfamethoxazole resistance in 44 cases (45.4%) were the leading resistances in this study. Escherichia coli was the dominant organism in 76.3% (74 patients) of study population which was resistant to ampicillin in 95.9% (71 cases). Despite the observed resistant to initial empirical regimen antibiotics (especially ampicillin), 81.4% of patients responded to empirical therapy. However, we believe till conductance of more detailed studies regarding the relationship between empirical therapy and antibiogram concordance, physicians take ampicillin-resistant E coli infection issue into accounts from the first steps of management of critically ill neonates. |
| first_indexed | 2024-12-13T20:56:19Z |
| format | Article |
| id | doaj.art-2a95d75d8181451a956e0b3d247fda1c |
| institution | Directory Open Access Journal |
| issn | 0044-6025 1735-9694 |
| language | English |
| last_indexed | 2024-12-13T20:56:19Z |
| publishDate | 2012-05-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Acta Medica Iranica |
| spelling | doaj.art-2a95d75d8181451a956e0b3d247fda1c2022-12-21T23:31:45ZengTehran University of Medical SciencesActa Medica Iranica0044-60251735-96942012-05-01505Neonatal Urinary Tract Infection: Clinical Response to Empirical Therapy versus In vitro Susceptibility at Bahrami Children’s Hospital- Neonatal Ward: 2001-2010Peymaneh Alizadeh Taheri0Behdad Navabi1Mamak Shariat2Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran.Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran.Maternal-Fetal-Neonatal Research Center, Tehran University of Medical Sciences, Tehran, Iran.Urinary tract infection (UTI) is a neonatal life threatening infection which is usually treated with ampicillin plus an aminoglycoside or a third-generation cephalosporin. Recently, growing number of Escherchia coli species resistant to ampicillin and aminoglycosides have raised concerns regarding the necessity to change the empirical therapy. This motivates us to determine neonatal UTI clinical response to the used empirical antibiotics. This study was designed as a Case Series. All neonates admitted to Bahrami Children Hospital, Tehran, Iran, during 2001- 2010 with a diagnosis of UTI surveyed by simple non-random sampling. Totally, 97 cases (including 83 (85.6%) term, 8 (8.2%) post-term and 6 (6.2%) preterm neonates) with a mean age of 15.85 ± 7.05 days at admission ,average weight of 3195.57 ± 553g at birth and 3276.29 ± 599.182 g at admission were studied. Ampicillin resistance in 93 cases (95.9%), gentamicin resistance in 51 cases (52.6%) and trimethoprim- sulfamethoxazole resistance in 44 cases (45.4%) were the leading resistances in this study. Escherichia coli was the dominant organism in 76.3% (74 patients) of study population which was resistant to ampicillin in 95.9% (71 cases). Despite the observed resistant to initial empirical regimen antibiotics (especially ampicillin), 81.4% of patients responded to empirical therapy. However, we believe till conductance of more detailed studies regarding the relationship between empirical therapy and antibiogram concordance, physicians take ampicillin-resistant E coli infection issue into accounts from the first steps of management of critically ill neonates.https://acta.tums.ac.ir/index.php/acta/article/view/3910NeonateUrinary tract infectionsAmpicillin resistanceEcherichia coliSepsis |
| spellingShingle | Peymaneh Alizadeh Taheri Behdad Navabi Mamak Shariat Neonatal Urinary Tract Infection: Clinical Response to Empirical Therapy versus In vitro Susceptibility at Bahrami Children’s Hospital- Neonatal Ward: 2001-2010 Acta Medica Iranica Neonate Urinary tract infections Ampicillin resistance Echerichia coli Sepsis |
| title | Neonatal Urinary Tract Infection: Clinical Response to Empirical Therapy versus In vitro Susceptibility at Bahrami Children’s Hospital- Neonatal Ward: 2001-2010 |
| title_full | Neonatal Urinary Tract Infection: Clinical Response to Empirical Therapy versus In vitro Susceptibility at Bahrami Children’s Hospital- Neonatal Ward: 2001-2010 |
| title_fullStr | Neonatal Urinary Tract Infection: Clinical Response to Empirical Therapy versus In vitro Susceptibility at Bahrami Children’s Hospital- Neonatal Ward: 2001-2010 |
| title_full_unstemmed | Neonatal Urinary Tract Infection: Clinical Response to Empirical Therapy versus In vitro Susceptibility at Bahrami Children’s Hospital- Neonatal Ward: 2001-2010 |
| title_short | Neonatal Urinary Tract Infection: Clinical Response to Empirical Therapy versus In vitro Susceptibility at Bahrami Children’s Hospital- Neonatal Ward: 2001-2010 |
| title_sort | neonatal urinary tract infection clinical response to empirical therapy versus in vitro susceptibility at bahrami children s hospital neonatal ward 2001 2010 |
| topic | Neonate Urinary tract infections Ampicillin resistance Echerichia coli Sepsis |
| url | https://acta.tums.ac.ir/index.php/acta/article/view/3910 |
| work_keys_str_mv | AT peymanehalizadehtaheri neonatalurinarytractinfectionclinicalresponsetoempiricaltherapyversusinvitrosusceptibilityatbahramichildrenshospitalneonatalward20012010 AT behdadnavabi neonatalurinarytractinfectionclinicalresponsetoempiricaltherapyversusinvitrosusceptibilityatbahramichildrenshospitalneonatalward20012010 AT mamakshariat neonatalurinarytractinfectionclinicalresponsetoempiricaltherapyversusinvitrosusceptibilityatbahramichildrenshospitalneonatalward20012010 |