Healthy aging and chronic kidney disease
The world population is aging and the prevalence of noncommunicable diseases such as chronic kidney disease (CKD) will increase significantly. With advances in medical treatment and public health, the human lifespan continues to outpace the health span and the last decade of life is generally spent...
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| Format: | Article |
| Language: | English |
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The Korean Society of Nephrology
2022-11-01
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| Series: | Kidney Research and Clinical Practice |
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| Online Access: | http://www.krcp-ksn.org/upload/pdf/j-krcp-22-112.pdf |
| _version_ | 1811184382083334144 |
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| author | Reshma Aziz Merchant Anantharaman Vathsala |
| author_facet | Reshma Aziz Merchant Anantharaman Vathsala |
| author_sort | Reshma Aziz Merchant |
| collection | DOAJ |
| description | The world population is aging and the prevalence of noncommunicable diseases such as chronic kidney disease (CKD) will increase significantly. With advances in medical treatment and public health, the human lifespan continues to outpace the health span and the last decade of life is generally spent in poor health. In 2015, the World Health Organization defined healthy aging as ‘the process of developing and maintaining the functional ability that enables wellbeing in older age.’ CKD is increasingly being recognized as a model of accelerated aging and is associated with physical performance decline, cognitive decline, falls and fractures, poor quality of life, loss of appetite, and inflammation. Frailty and dementia are the final pathways and key determinants of disability and mortality independent of underlying disease. CKD, dementia, and frailty share a triangular relationship with synergistic actions and have common risk factors wherein CKD accelerates frailty and dementia through mechanisms such as uremic toxicity, metabolic acidosis and derangements, anorexia and malnutrition, dialysis-related hemodynamic instability, and sleep disturbance. Frailty accelerates glomerular filtration decline as well as dialysis induction in CKD and more than doubles the mortality risk. Anorexia is one of the major causes of protein-energy malnutrition, which is also prevalent in the aging population and warrants screening. Healthcare systems across the world need to have a system in place for the prevention of CKD amongst high-risk older adults, focusing on screening for poor prognostic factors amongst patients with CKD such as frailty, poor appetite, and cognitive impairment and providing necessary person-centered interventions to reverse underlying factors that may contribute to poor outcomes. |
| first_indexed | 2024-04-11T13:12:20Z |
| format | Article |
| id | doaj.art-2a9713b5ec064f67bd6a12a69d172439 |
| institution | Directory Open Access Journal |
| issn | 2211-9132 2211-9140 |
| language | English |
| last_indexed | 2024-04-11T13:12:20Z |
| publishDate | 2022-11-01 |
| publisher | The Korean Society of Nephrology |
| record_format | Article |
| series | Kidney Research and Clinical Practice |
| spelling | doaj.art-2a9713b5ec064f67bd6a12a69d1724392022-12-22T04:22:33ZengThe Korean Society of NephrologyKidney Research and Clinical Practice2211-91322211-91402022-11-0141664465610.23876/j.krcp.22.1126172Healthy aging and chronic kidney diseaseReshma Aziz Merchant0Anantharaman Vathsala1 Division of Geriatric Medicine, Department of Medicine, National University Hospital, Singapore, Singapore Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeThe world population is aging and the prevalence of noncommunicable diseases such as chronic kidney disease (CKD) will increase significantly. With advances in medical treatment and public health, the human lifespan continues to outpace the health span and the last decade of life is generally spent in poor health. In 2015, the World Health Organization defined healthy aging as ‘the process of developing and maintaining the functional ability that enables wellbeing in older age.’ CKD is increasingly being recognized as a model of accelerated aging and is associated with physical performance decline, cognitive decline, falls and fractures, poor quality of life, loss of appetite, and inflammation. Frailty and dementia are the final pathways and key determinants of disability and mortality independent of underlying disease. CKD, dementia, and frailty share a triangular relationship with synergistic actions and have common risk factors wherein CKD accelerates frailty and dementia through mechanisms such as uremic toxicity, metabolic acidosis and derangements, anorexia and malnutrition, dialysis-related hemodynamic instability, and sleep disturbance. Frailty accelerates glomerular filtration decline as well as dialysis induction in CKD and more than doubles the mortality risk. Anorexia is one of the major causes of protein-energy malnutrition, which is also prevalent in the aging population and warrants screening. Healthcare systems across the world need to have a system in place for the prevention of CKD amongst high-risk older adults, focusing on screening for poor prognostic factors amongst patients with CKD such as frailty, poor appetite, and cognitive impairment and providing necessary person-centered interventions to reverse underlying factors that may contribute to poor outcomes.http://www.krcp-ksn.org/upload/pdf/j-krcp-22-112.pdfanorexiachronic kidney diseasecognitive impairmentsfrailtyhealthy aging |
| spellingShingle | Reshma Aziz Merchant Anantharaman Vathsala Healthy aging and chronic kidney disease Kidney Research and Clinical Practice anorexia chronic kidney disease cognitive impairments frailty healthy aging |
| title | Healthy aging and chronic kidney disease |
| title_full | Healthy aging and chronic kidney disease |
| title_fullStr | Healthy aging and chronic kidney disease |
| title_full_unstemmed | Healthy aging and chronic kidney disease |
| title_short | Healthy aging and chronic kidney disease |
| title_sort | healthy aging and chronic kidney disease |
| topic | anorexia chronic kidney disease cognitive impairments frailty healthy aging |
| url | http://www.krcp-ksn.org/upload/pdf/j-krcp-22-112.pdf |
| work_keys_str_mv | AT reshmaazizmerchant healthyagingandchronickidneydisease AT anantharamanvathsala healthyagingandchronickidneydisease |