Outcomes of patients with coronavirus disease versus other lung infections requiring venovenous extracorporeal membrane oxygenation
Background: Patients with Coronavirus Disease (COVID-19) often develop severe acute respiratory distress syndrome (ARDS) requiring prolonged mechanical ventilation (MV), and venovenous extracorporeal membrane oxygenation (V–V ECMO).Mortality in COVID-19 patients on V–V ECMO was exceptionally high; t...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023046492 |
| _version_ | 1797797990204702720 |
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| author | Boris Kuzmin Arevik Movsisyan Florian Praetsch Thomas Schilling Anke Lux Mohammad Fadel Faranak Azizzadeh Julia Crackau Olaf Keyser George Awad Thomas Hachenberg Jens Wippermann Maximilian Scherner |
| author_facet | Boris Kuzmin Arevik Movsisyan Florian Praetsch Thomas Schilling Anke Lux Mohammad Fadel Faranak Azizzadeh Julia Crackau Olaf Keyser George Awad Thomas Hachenberg Jens Wippermann Maximilian Scherner |
| author_sort | Boris Kuzmin |
| collection | DOAJ |
| description | Background: Patients with Coronavirus Disease (COVID-19) often develop severe acute respiratory distress syndrome (ARDS) requiring prolonged mechanical ventilation (MV), and venovenous extracorporeal membrane oxygenation (V–V ECMO).Mortality in COVID-19 patients on V–V ECMO was exceptionally high; therefore, whether survival can be ameliorated should be investigated. Methods: We collected data from 85 patients with severe ARDS who required ECMO support at the University Hospital Magdeburg from 2014 to 2021. The patients were divided into the COVID-19 group (52 patients) and the non-COVID-19 group (33 patients). Demographic and pre-, intra-, and post-ECMO data were retrospectively recorded. The parameters of mechanical ventilation, laboratory data before using ECMO, and during ECMO were compared. Results: There was a significant difference between the two groups regarding survival: 38.5% of COVID-19 patients and 63.6% of non-COVID-19 patients survived 60 days (p = 0.024). COVID-19 patients required V–V ECMO after 6.5 days of MV, while non-COVID-19 patients required V–V ECMO after 2.0 days of MV (p = 0.048). The COVID-19 group had a greater proportion of patients with ischemic heart disease (21.2% vs 3%, p = 0.019). The rates of most complications were comparable in both groups, whereas the COVID-19 group showed a significantly higher rate of cerebral bleeding (23.1 vs 6.1%, p = 0.039) and lung bacterial superinfection (53.8% vs 9.1%, p = <0.001). Conclusion: The higher 60-days mortality among patients with COVID-19 with severe ARDS was attributable to superinfection, a higher risk of intracerebral bleeding, and the pre-existing ischemic heart disease. |
| first_indexed | 2024-03-13T03:56:40Z |
| format | Article |
| id | doaj.art-2a9778dc49ba4956a1d25a861b9e1028 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-13T03:56:40Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-2a9778dc49ba4956a1d25a861b9e10282023-06-22T05:04:29ZengElsevierHeliyon2405-84402023-06-0196e17441Outcomes of patients with coronavirus disease versus other lung infections requiring venovenous extracorporeal membrane oxygenationBoris Kuzmin0Arevik Movsisyan1Florian Praetsch2Thomas Schilling3Anke Lux4Mohammad Fadel5Faranak Azizzadeh6Julia Crackau7Olaf Keyser8George Awad9Thomas Hachenberg10Jens Wippermann11Maximilian Scherner12Department of Cardiothoracic Surgery, University Hospital, Magdeburg, Germany; Corresponding author. Department of Cardiothoracic Surgery, University Hospital, Magdeburg, Leipziger str. 44, 39120 Magdeburg, Germany.Department of Cardiothoracic Surgery, University Hospital, Magdeburg, GermanyDepartment of Anesthesiology and Intensive Care Medicine, University Hospital, Magdeburg, GermanyDepartment of Anesthesiology and Intensive Care Medicine, University Hospital, Magdeburg, GermanyInstitute of Biometry and Medical Informatics, University Hospital, Magdeburg, GermanyDepartment of Cardiothoracic Surgery, University Hospital, Magdeburg, GermanyDepartment of Cardiothoracic Surgery, University Hospital, Magdeburg, GermanyDepartment of Cardiothoracic Surgery, University Hospital, Magdeburg, GermanyDepartment of Cardiothoracic Surgery, University Hospital, Magdeburg, GermanyDepartment of Cardiothoracic Surgery, University Hospital, Magdeburg, GermanyDepartment of Anesthesiology and Intensive Care Medicine, University Hospital, Magdeburg, GermanyDepartment of Cardiothoracic Surgery, University Hospital, Magdeburg, GermanyDepartment of Cardiothoracic Surgery, University Hospital, Magdeburg, Germany; Corresponding author.Background: Patients with Coronavirus Disease (COVID-19) often develop severe acute respiratory distress syndrome (ARDS) requiring prolonged mechanical ventilation (MV), and venovenous extracorporeal membrane oxygenation (V–V ECMO).Mortality in COVID-19 patients on V–V ECMO was exceptionally high; therefore, whether survival can be ameliorated should be investigated. Methods: We collected data from 85 patients with severe ARDS who required ECMO support at the University Hospital Magdeburg from 2014 to 2021. The patients were divided into the COVID-19 group (52 patients) and the non-COVID-19 group (33 patients). Demographic and pre-, intra-, and post-ECMO data were retrospectively recorded. The parameters of mechanical ventilation, laboratory data before using ECMO, and during ECMO were compared. Results: There was a significant difference between the two groups regarding survival: 38.5% of COVID-19 patients and 63.6% of non-COVID-19 patients survived 60 days (p = 0.024). COVID-19 patients required V–V ECMO after 6.5 days of MV, while non-COVID-19 patients required V–V ECMO after 2.0 days of MV (p = 0.048). The COVID-19 group had a greater proportion of patients with ischemic heart disease (21.2% vs 3%, p = 0.019). The rates of most complications were comparable in both groups, whereas the COVID-19 group showed a significantly higher rate of cerebral bleeding (23.1 vs 6.1%, p = 0.039) and lung bacterial superinfection (53.8% vs 9.1%, p = <0.001). Conclusion: The higher 60-days mortality among patients with COVID-19 with severe ARDS was attributable to superinfection, a higher risk of intracerebral bleeding, and the pre-existing ischemic heart disease.http://www.sciencedirect.com/science/article/pii/S2405844023046492Viral pneumoniaAcute respiratory failureExtracorporeal membrane oxygenationBacterial superinfectionCerebral bleeding |
| spellingShingle | Boris Kuzmin Arevik Movsisyan Florian Praetsch Thomas Schilling Anke Lux Mohammad Fadel Faranak Azizzadeh Julia Crackau Olaf Keyser George Awad Thomas Hachenberg Jens Wippermann Maximilian Scherner Outcomes of patients with coronavirus disease versus other lung infections requiring venovenous extracorporeal membrane oxygenation Heliyon Viral pneumonia Acute respiratory failure Extracorporeal membrane oxygenation Bacterial superinfection Cerebral bleeding |
| title | Outcomes of patients with coronavirus disease versus other lung infections requiring venovenous extracorporeal membrane oxygenation |
| title_full | Outcomes of patients with coronavirus disease versus other lung infections requiring venovenous extracorporeal membrane oxygenation |
| title_fullStr | Outcomes of patients with coronavirus disease versus other lung infections requiring venovenous extracorporeal membrane oxygenation |
| title_full_unstemmed | Outcomes of patients with coronavirus disease versus other lung infections requiring venovenous extracorporeal membrane oxygenation |
| title_short | Outcomes of patients with coronavirus disease versus other lung infections requiring venovenous extracorporeal membrane oxygenation |
| title_sort | outcomes of patients with coronavirus disease versus other lung infections requiring venovenous extracorporeal membrane oxygenation |
| topic | Viral pneumonia Acute respiratory failure Extracorporeal membrane oxygenation Bacterial superinfection Cerebral bleeding |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023046492 |
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