A novel method for efficient generation of antigen-specific effector T-cells using dendritic cells transduced with recombinant adeno-associated virus and p38 kinase blockade

A novel method for efficient generation of antigen-specific effector T-cells using dendritic cells transduced with recombinant adeno-associated virus and p38 kinase blockade

Abstract Background The inefficacy of standard therapeutic strategies for ovarian cancer is reflected by the enduring poor prognosis of this malignancy. Due to the potential for exquisite specificity, sensitivity and long-term memory, immunotherapy offers an alternative modality for durable control...

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Bibliographic Details
Main Authors: Leonardo Mirandola, Maurizio Chiriva-Internati, Robert Bresalier, Lucia Piccotti, Fabio Grizzi, Francesco M. Marincola
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Journal of Translational Medicine
Subjects:
Ovarian cancer vaccine
Dendritic cells
p38 MAP kinase
T-regs
Online Access:https://doi.org/10.1186/s12967-019-02163-4

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