Exploratory cohort study into underlying mechanism of differences in estrogen metabolism between Asian and Caucasian women during assisted reproductive technology treatment
Objective: Explore whether racial differences in prevalence of CYP1A2∗1F polymorphism underlies estrogen metabolism differences among Asians and Caucasians. Design: Prospective cohort study. Setting: University-based fertility practice. Patient(s): Asian or Caucasian patients who underwent ovarian s...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | F&S Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666334123001046 |
| _version_ | 1797386759097548800 |
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| author | Amy Kaing, M.D. Amanda Adeleye, M.D. Bani Tamraz, Pharm.D., Ph.D. Victor Y. Fujimoto, M.D. |
| author_facet | Amy Kaing, M.D. Amanda Adeleye, M.D. Bani Tamraz, Pharm.D., Ph.D. Victor Y. Fujimoto, M.D. |
| author_sort | Amy Kaing, M.D. |
| collection | DOAJ |
| description | Objective: Explore whether racial differences in prevalence of CYP1A2∗1F polymorphism underlies estrogen metabolism differences among Asians and Caucasians. Design: Prospective cohort study. Setting: University-based fertility practice. Patient(s): Asian or Caucasian patients who underwent ovarian stimulation (OS) or programmed cycle frozen embryo transfer (FET) between October 2019 and April 2021. Intervention(s): None. Main Outcome Measure(s): Trigger-day serum E2 per oocyte retrieved in OS cycles, and E2 on day of lining check in FET cycles. Result(s): Seventy-one participants were enrolled, 55 in OS group (29 Caucasian and 26 Asian) and 16 in FET group (10 Caucasian and 6 Asian). Peak E2 per oocyte retrieved in the OS group (n = 48) differed by race, with significantly lower levels in Caucasians compared with Asians (177.5 ± 64.2 vs. 261.1 ± 139.5 pg/mL). Prevalence of CYP1A2∗1F polymorphism did not significantly differ by race. Compared using Kruskal–Wallis test, peak E2 per oocyte retrieved did not differ by CYP1A2∗1F genotype. In multivariate linear regression model, adjusting for body mass index, caffeine intake, and self-reported race, there remained no significant correlation. In FET group, serum E2 on day of lining check was also not significantly different by CYP1A2∗1F genotype. Conclusion(s): Although a consistent difference in serum E2 between Asians and Caucasians undergoing OS was noted, the CYP1A2∗1F polymorphism is unlikely the primary driver of this difference. |
| first_indexed | 2024-03-08T22:13:59Z |
| format | Article |
| id | doaj.art-2a9ac75a2e904bc7b365485a7076d710 |
| institution | Directory Open Access Journal |
| issn | 2666-3341 |
| language | English |
| last_indexed | 2024-03-08T22:13:59Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | F&S Reports |
| spelling | doaj.art-2a9ac75a2e904bc7b365485a7076d7102023-12-19T04:17:29ZengElsevierF&S Reports2666-33412023-12-0144396401Exploratory cohort study into underlying mechanism of differences in estrogen metabolism between Asian and Caucasian women during assisted reproductive technology treatmentAmy Kaing, M.D.0Amanda Adeleye, M.D.1Bani Tamraz, Pharm.D., Ph.D.2Victor Y. Fujimoto, M.D.3Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, California; Correspondence: Amy Kaing, M.D., Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, 499 Illinois St., Sixth Floor, San Francisco, California 94158.Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, California; Section of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Chicago, Chicago, Illinois; Department of Clinical Pharmacy, University of California, San Francisco, San Francisco, CaliforniaDepartment of Clinical Pharmacy, University of California, San Francisco, San Francisco, CaliforniaDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, CaliforniaObjective: Explore whether racial differences in prevalence of CYP1A2∗1F polymorphism underlies estrogen metabolism differences among Asians and Caucasians. Design: Prospective cohort study. Setting: University-based fertility practice. Patient(s): Asian or Caucasian patients who underwent ovarian stimulation (OS) or programmed cycle frozen embryo transfer (FET) between October 2019 and April 2021. Intervention(s): None. Main Outcome Measure(s): Trigger-day serum E2 per oocyte retrieved in OS cycles, and E2 on day of lining check in FET cycles. Result(s): Seventy-one participants were enrolled, 55 in OS group (29 Caucasian and 26 Asian) and 16 in FET group (10 Caucasian and 6 Asian). Peak E2 per oocyte retrieved in the OS group (n = 48) differed by race, with significantly lower levels in Caucasians compared with Asians (177.5 ± 64.2 vs. 261.1 ± 139.5 pg/mL). Prevalence of CYP1A2∗1F polymorphism did not significantly differ by race. Compared using Kruskal–Wallis test, peak E2 per oocyte retrieved did not differ by CYP1A2∗1F genotype. In multivariate linear regression model, adjusting for body mass index, caffeine intake, and self-reported race, there remained no significant correlation. In FET group, serum E2 on day of lining check was also not significantly different by CYP1A2∗1F genotype. Conclusion(s): Although a consistent difference in serum E2 between Asians and Caucasians undergoing OS was noted, the CYP1A2∗1F polymorphism is unlikely the primary driver of this difference.http://www.sciencedirect.com/science/article/pii/S2666334123001046Assisted reproductive technologiesCYP1A2∗1Festrogen metabolismracial disparity |
| spellingShingle | Amy Kaing, M.D. Amanda Adeleye, M.D. Bani Tamraz, Pharm.D., Ph.D. Victor Y. Fujimoto, M.D. Exploratory cohort study into underlying mechanism of differences in estrogen metabolism between Asian and Caucasian women during assisted reproductive technology treatment F&S Reports Assisted reproductive technologies CYP1A2∗1F estrogen metabolism racial disparity |
| title | Exploratory cohort study into underlying mechanism of differences in estrogen metabolism between Asian and Caucasian women during assisted reproductive technology treatment |
| title_full | Exploratory cohort study into underlying mechanism of differences in estrogen metabolism between Asian and Caucasian women during assisted reproductive technology treatment |
| title_fullStr | Exploratory cohort study into underlying mechanism of differences in estrogen metabolism between Asian and Caucasian women during assisted reproductive technology treatment |
| title_full_unstemmed | Exploratory cohort study into underlying mechanism of differences in estrogen metabolism between Asian and Caucasian women during assisted reproductive technology treatment |
| title_short | Exploratory cohort study into underlying mechanism of differences in estrogen metabolism between Asian and Caucasian women during assisted reproductive technology treatment |
| title_sort | exploratory cohort study into underlying mechanism of differences in estrogen metabolism between asian and caucasian women during assisted reproductive technology treatment |
| topic | Assisted reproductive technologies CYP1A2∗1F estrogen metabolism racial disparity |
| url | http://www.sciencedirect.com/science/article/pii/S2666334123001046 |
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