Re-Irradiation for Recurrent Cervical Cancer: A State-of-the-Art Review
The recurrence rate of cervical cancer after primary treatment can reach 60%, and a poor prognosis is reported in most cases. Treatment options for the recurrence of cervical cancer mainly depend on the prior treatment regimen and the location of recurrent lesions. Re-irradiation is still considered...
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MDPI AG
2022-07-01
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Series: | Current Oncology |
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Online Access: | https://www.mdpi.com/1718-7729/29/8/418 |
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author | Zongyan Shen Ang Qu Ping Jiang Yuliang Jiang Haitao Sun Junjie Wang |
author_facet | Zongyan Shen Ang Qu Ping Jiang Yuliang Jiang Haitao Sun Junjie Wang |
author_sort | Zongyan Shen |
collection | DOAJ |
description | The recurrence rate of cervical cancer after primary treatment can reach 60%, and a poor prognosis is reported in most cases. Treatment options for the recurrence of cervical cancer mainly depend on the prior treatment regimen and the location of recurrent lesions. Re-irradiation is still considered as a clinical challenge, owing to a high incidence of toxicity, especially in in-field recurrence within a short period of time. Recent advances in radiotherapy have preliminarily revealed encouraging outcomes of re-irradiation. Several centers have concentrasted on stereotactic body radiation therapy (SBRT) for the treatment of well-selected cases. Meanwhile, as the image-guiding techniques become more precise, a better dose profile can also be achieved in brachytherapy, including high-dose-rate interstitial brachytherapy (HDR-ISBT) and permanent radioactive seed implantation (PRSI). These treatment modalities have shown promising efficacy with a tolerable toxicity, providing further treatment options for recurrent cervical cancer. However, it is highly unlikely to draw a definite conclusion from all of those studies due to the large heterogeneity among them and the lack of large-scale prospective studies. This study mainly reviews and summarizes the progress of re-irradiation for recurrent cervical cancer in recent years, in order to provide potential treatment regimens for the management of re-irradiation. |
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format | Article |
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institution | Directory Open Access Journal |
issn | 1198-0052 1718-7729 |
language | English |
last_indexed | 2024-03-09T04:34:38Z |
publishDate | 2022-07-01 |
publisher | MDPI AG |
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series | Current Oncology |
spelling | doaj.art-2a9ed018301740c1bb89fb498993be632023-12-03T13:30:35ZengMDPI AGCurrent Oncology1198-00521718-77292022-07-012985262527710.3390/curroncol29080418Re-Irradiation for Recurrent Cervical Cancer: A State-of-the-Art ReviewZongyan Shen0Ang Qu1Ping Jiang2Yuliang Jiang3Haitao Sun4Junjie Wang5Department of Radiation Oncology, Peking University Third Hospital, Beijing 100191, ChinaDepartment of Radiation Oncology, Peking University Third Hospital, Beijing 100191, ChinaDepartment of Radiation Oncology, Peking University Third Hospital, Beijing 100191, ChinaDepartment of Radiation Oncology, Peking University Third Hospital, Beijing 100191, ChinaDepartment of Radiation Oncology, Peking University Third Hospital, Beijing 100191, ChinaDepartment of Radiation Oncology, Peking University Third Hospital, Beijing 100191, ChinaThe recurrence rate of cervical cancer after primary treatment can reach 60%, and a poor prognosis is reported in most cases. Treatment options for the recurrence of cervical cancer mainly depend on the prior treatment regimen and the location of recurrent lesions. Re-irradiation is still considered as a clinical challenge, owing to a high incidence of toxicity, especially in in-field recurrence within a short period of time. Recent advances in radiotherapy have preliminarily revealed encouraging outcomes of re-irradiation. Several centers have concentrasted on stereotactic body radiation therapy (SBRT) for the treatment of well-selected cases. Meanwhile, as the image-guiding techniques become more precise, a better dose profile can also be achieved in brachytherapy, including high-dose-rate interstitial brachytherapy (HDR-ISBT) and permanent radioactive seed implantation (PRSI). These treatment modalities have shown promising efficacy with a tolerable toxicity, providing further treatment options for recurrent cervical cancer. However, it is highly unlikely to draw a definite conclusion from all of those studies due to the large heterogeneity among them and the lack of large-scale prospective studies. This study mainly reviews and summarizes the progress of re-irradiation for recurrent cervical cancer in recent years, in order to provide potential treatment regimens for the management of re-irradiation.https://www.mdpi.com/1718-7729/29/8/418re-irradiationrecurrent cervical cancerstereotactic body radiation therapyhigh-dose-rate interstitial brachytherapypermanent radioactive seed implantation |
spellingShingle | Zongyan Shen Ang Qu Ping Jiang Yuliang Jiang Haitao Sun Junjie Wang Re-Irradiation for Recurrent Cervical Cancer: A State-of-the-Art Review Current Oncology re-irradiation recurrent cervical cancer stereotactic body radiation therapy high-dose-rate interstitial brachytherapy permanent radioactive seed implantation |
title | Re-Irradiation for Recurrent Cervical Cancer: A State-of-the-Art Review |
title_full | Re-Irradiation for Recurrent Cervical Cancer: A State-of-the-Art Review |
title_fullStr | Re-Irradiation for Recurrent Cervical Cancer: A State-of-the-Art Review |
title_full_unstemmed | Re-Irradiation for Recurrent Cervical Cancer: A State-of-the-Art Review |
title_short | Re-Irradiation for Recurrent Cervical Cancer: A State-of-the-Art Review |
title_sort | re irradiation for recurrent cervical cancer a state of the art review |
topic | re-irradiation recurrent cervical cancer stereotactic body radiation therapy high-dose-rate interstitial brachytherapy permanent radioactive seed implantation |
url | https://www.mdpi.com/1718-7729/29/8/418 |
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