Relationship between the Chromosome Structural Dynamics and Gene Expression—A Chicken and Egg Dilemma?
Prokaryotic transcription was extensively studied over the last half-century. A great deal of data has been accumulated regarding the control of gene expression by transcription factors regulating their target genes by binding at specific DNA sites. However, there is a significant gap between the me...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-04-01
|
| Series: | Microorganisms |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-2607/10/5/846 |
| _version_ | 1797497690666303488 |
|---|---|
| author | Diana Le Berre Sylvie Reverchon Georgi Muskhelishvili William Nasser |
| author_facet | Diana Le Berre Sylvie Reverchon Georgi Muskhelishvili William Nasser |
| author_sort | Diana Le Berre |
| collection | DOAJ |
| description | Prokaryotic transcription was extensively studied over the last half-century. A great deal of data has been accumulated regarding the control of gene expression by transcription factors regulating their target genes by binding at specific DNA sites. However, there is a significant gap between the mechanistic description of transcriptional control obtained from in vitro biochemical studies and the complexity of transcriptional regulation in the context of the living cell. Indeed, recent studies provide ample evidence for additional levels of complexity pertaining to the regulation of transcription in vivo, such as, for example, the role of the subcellular localization and spatial organization of different molecular components involved in the transcriptional control and, especially, the role of chromosome configurational dynamics. The question as to how the chromosome is dynamically reorganized under the changing environmental conditions and how this reorganization is related to gene expression is still far from being clear. In this article, we focus on the relationships between the chromosome structural dynamics and modulation of gene expression during bacterial adaptation. We argue that spatial organization of the bacterial chromosome is of central importance in the adaptation of gene expression to changing environmental conditions and vice versa, that gene expression affects chromosome dynamics. |
| first_indexed | 2024-03-10T03:22:50Z |
| format | Article |
| id | doaj.art-2a9eeca48c374aa888a08ec5fc5d4983 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-10T03:22:50Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-2a9eeca48c374aa888a08ec5fc5d49832023-11-23T12:13:49ZengMDPI AGMicroorganisms2076-26072022-04-0110584610.3390/microorganisms10050846Relationship between the Chromosome Structural Dynamics and Gene Expression—A Chicken and Egg Dilemma?Diana Le Berre0Sylvie Reverchon1Georgi Muskhelishvili2William Nasser3Université de Lyon, Université Claude Bernard Lyon 1, INSA-Lyon, CNRS, UMR5240 MAP, CEDEX, F-69622 Villeurbanne, FranceUniversité de Lyon, Université Claude Bernard Lyon 1, INSA-Lyon, CNRS, UMR5240 MAP, CEDEX, F-69622 Villeurbanne, FranceSchool of Natural Sciences, Agricultural University of Georgia, 0159 Tbilisi, GeorgiaUniversité de Lyon, Université Claude Bernard Lyon 1, INSA-Lyon, CNRS, UMR5240 MAP, CEDEX, F-69622 Villeurbanne, FranceProkaryotic transcription was extensively studied over the last half-century. A great deal of data has been accumulated regarding the control of gene expression by transcription factors regulating their target genes by binding at specific DNA sites. However, there is a significant gap between the mechanistic description of transcriptional control obtained from in vitro biochemical studies and the complexity of transcriptional regulation in the context of the living cell. Indeed, recent studies provide ample evidence for additional levels of complexity pertaining to the regulation of transcription in vivo, such as, for example, the role of the subcellular localization and spatial organization of different molecular components involved in the transcriptional control and, especially, the role of chromosome configurational dynamics. The question as to how the chromosome is dynamically reorganized under the changing environmental conditions and how this reorganization is related to gene expression is still far from being clear. In this article, we focus on the relationships between the chromosome structural dynamics and modulation of gene expression during bacterial adaptation. We argue that spatial organization of the bacterial chromosome is of central importance in the adaptation of gene expression to changing environmental conditions and vice versa, that gene expression affects chromosome dynamics.https://www.mdpi.com/2076-2607/10/5/846bacteriagenetic regulationtranscriptionDNA supercoilingchromosome dynamicschromosomal expression domains |
| spellingShingle | Diana Le Berre Sylvie Reverchon Georgi Muskhelishvili William Nasser Relationship between the Chromosome Structural Dynamics and Gene Expression—A Chicken and Egg Dilemma? Microorganisms bacteria genetic regulation transcription DNA supercoiling chromosome dynamics chromosomal expression domains |
| title | Relationship between the Chromosome Structural Dynamics and Gene Expression—A Chicken and Egg Dilemma? |
| title_full | Relationship between the Chromosome Structural Dynamics and Gene Expression—A Chicken and Egg Dilemma? |
| title_fullStr | Relationship between the Chromosome Structural Dynamics and Gene Expression—A Chicken and Egg Dilemma? |
| title_full_unstemmed | Relationship between the Chromosome Structural Dynamics and Gene Expression—A Chicken and Egg Dilemma? |
| title_short | Relationship between the Chromosome Structural Dynamics and Gene Expression—A Chicken and Egg Dilemma? |
| title_sort | relationship between the chromosome structural dynamics and gene expression a chicken and egg dilemma |
| topic | bacteria genetic regulation transcription DNA supercoiling chromosome dynamics chromosomal expression domains |
| url | https://www.mdpi.com/2076-2607/10/5/846 |
| work_keys_str_mv | AT dianaleberre relationshipbetweenthechromosomestructuraldynamicsandgeneexpressionachickenandeggdilemma AT sylviereverchon relationshipbetweenthechromosomestructuraldynamicsandgeneexpressionachickenandeggdilemma AT georgimuskhelishvili relationshipbetweenthechromosomestructuraldynamicsandgeneexpressionachickenandeggdilemma AT williamnasser relationshipbetweenthechromosomestructuraldynamicsandgeneexpressionachickenandeggdilemma |