RITUXIMAB EFFICACY IN TREATING SYSTEMIC JUVENILE ARTHRITIS REFRACTORY TO TRADITIONAL IMMUNOSUPPRESSANT AND TNF BLOCKER THERAPY
The article describes the clinical case of a difficult systemic juvenile arthritis refractory to traditional immunosuppressant and TNF blocker therapy. The disease was characterized by such extra-articulate manifestations as fever, lymphadenopathy, hepatolienomegaly, polyorrhymenitis, generalized jo...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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"Paediatrician" Publishers LLC
2007-05-01
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| Series: | Вопросы современной педиатрии |
| Online Access: | https://vsp.spr-journal.ru/jour/article/view/1232 |
| _version_ | 1797697733436375040 |
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| author | E.I. Alexeeva S.S. Akulova E.L. Semikina T.M. Bzarova K.B. Isaeva |
| author_facet | E.I. Alexeeva S.S. Akulova E.L. Semikina T.M. Bzarova K.B. Isaeva |
| author_sort | E.I. Alexeeva |
| collection | DOAJ |
| description | The article describes the clinical case of a difficult systemic juvenile arthritis refractory to traditional immunosuppressant and TNF blocker therapy. The disease was characterized by such extra-articulate manifestations as fever, lymphadenopathy, hepatolienomegaly, polyorrhymenitis, generalized joint affection and high laboratory activity indicators (ESR, CRP). The inclusion of rituximab stimulated the remission of systemic manifestations and the joint syndrome, as well as normalized the laboratory disease activity indicators. The therapeutic effect duration was 22 weeks upon the initial infusion of rituximab. The results demonstrate that rituximab is a promising medication for treating systemic juvenile arthritis children.Key words: children, treatment, rituximab, juvenile arthritis. |
| first_indexed | 2024-03-12T03:44:19Z |
| format | Article |
| id | doaj.art-2aa24a738c214ddc9e05ab2ae5a6e97a |
| institution | Directory Open Access Journal |
| issn | 1682-5527 1682-5535 |
| language | English |
| last_indexed | 2024-03-12T03:44:19Z |
| publishDate | 2007-05-01 |
| publisher | "Paediatrician" Publishers LLC |
| record_format | Article |
| series | Вопросы современной педиатрии |
| spelling | doaj.art-2aa24a738c214ddc9e05ab2ae5a6e97a2023-09-03T12:58:14Zeng"Paediatrician" Publishers LLCВопросы современной педиатрии1682-55271682-55352007-05-0163941001232RITUXIMAB EFFICACY IN TREATING SYSTEMIC JUVENILE ARTHRITIS REFRACTORY TO TRADITIONAL IMMUNOSUPPRESSANT AND TNF BLOCKER THERAPYE.I. Alexeeva0S.S. Akulova1E.L. Semikina2T.M. Bzarova3K.B. Isaeva4Научный центр здоровья детей РАМН, МоскваНаучный центр здоровья детей РАМН, МоскваНаучный центр здоровья детей РАМН, МоскваНаучный центр здоровья детей РАМН, МоскваНаучный центр здоровья детей РАМН, МоскваThe article describes the clinical case of a difficult systemic juvenile arthritis refractory to traditional immunosuppressant and TNF blocker therapy. The disease was characterized by such extra-articulate manifestations as fever, lymphadenopathy, hepatolienomegaly, polyorrhymenitis, generalized joint affection and high laboratory activity indicators (ESR, CRP). The inclusion of rituximab stimulated the remission of systemic manifestations and the joint syndrome, as well as normalized the laboratory disease activity indicators. The therapeutic effect duration was 22 weeks upon the initial infusion of rituximab. The results demonstrate that rituximab is a promising medication for treating systemic juvenile arthritis children.Key words: children, treatment, rituximab, juvenile arthritis.https://vsp.spr-journal.ru/jour/article/view/1232 |
| spellingShingle | E.I. Alexeeva S.S. Akulova E.L. Semikina T.M. Bzarova K.B. Isaeva RITUXIMAB EFFICACY IN TREATING SYSTEMIC JUVENILE ARTHRITIS REFRACTORY TO TRADITIONAL IMMUNOSUPPRESSANT AND TNF BLOCKER THERAPY Вопросы современной педиатрии |
| title | RITUXIMAB EFFICACY IN TREATING SYSTEMIC JUVENILE ARTHRITIS REFRACTORY TO TRADITIONAL IMMUNOSUPPRESSANT AND TNF BLOCKER THERAPY |
| title_full | RITUXIMAB EFFICACY IN TREATING SYSTEMIC JUVENILE ARTHRITIS REFRACTORY TO TRADITIONAL IMMUNOSUPPRESSANT AND TNF BLOCKER THERAPY |
| title_fullStr | RITUXIMAB EFFICACY IN TREATING SYSTEMIC JUVENILE ARTHRITIS REFRACTORY TO TRADITIONAL IMMUNOSUPPRESSANT AND TNF BLOCKER THERAPY |
| title_full_unstemmed | RITUXIMAB EFFICACY IN TREATING SYSTEMIC JUVENILE ARTHRITIS REFRACTORY TO TRADITIONAL IMMUNOSUPPRESSANT AND TNF BLOCKER THERAPY |
| title_short | RITUXIMAB EFFICACY IN TREATING SYSTEMIC JUVENILE ARTHRITIS REFRACTORY TO TRADITIONAL IMMUNOSUPPRESSANT AND TNF BLOCKER THERAPY |
| title_sort | rituximab efficacy in treating systemic juvenile arthritis refractory to traditional immunosuppressant and tnf blocker therapy |
| url | https://vsp.spr-journal.ru/jour/article/view/1232 |
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