Drug therapy of leprosy
Leprosy (Hansen’s disease) is a chronic granulomatous bacterial infection mainly affecting the skin and peripheral nervous system yet also involving other organs and systems as a result of a pathological process. The causative agent of leprosy - Mycobacterium leprae - is an obligate intracellular mi...
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| Format: | Article |
| Language: | English |
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State Scientific Center of Dermatovenereology and Cosmetology
2017-08-01
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| Series: | Vestnik Dermatologii i Venerologii |
| Subjects: | |
| Online Access: | https://www.vestnikdv.ru/jour/article/view/252 |
| _version_ | 1797714143371853824 |
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| author | A. A. Kubanov A. E. Karamova A. A. Vorontsova P. A. Kalinina |
| author_facet | A. A. Kubanov A. E. Karamova A. A. Vorontsova P. A. Kalinina |
| author_sort | A. A. Kubanov |
| collection | DOAJ |
| description | Leprosy (Hansen’s disease) is a chronic granulomatous bacterial infection mainly affecting the skin and peripheral nervous system yet also involving other organs and systems as a result of a pathological process. The causative agent of leprosy - Mycobacterium leprae - is an obligate intracellular microorganism. Despite the removal of a threat of a leprosy epidemic, European countries still record outbreaks of the disease mainly among migrants coming from endemic areas. A golden standard of the treatment of leprosy is a WHO-recommended combined drug therapy comprising drugs such as dapsone, clofazimine and rifampicin. The article provides current data on the mechanisms of action, efficacy and safety of these drugs and their combined scheme of treatment obtained as a result of clinical trials. Moreover, it also reviews new regimens of the drug therapy of leprosy including those with the use of drugs from the group of fluoroquinols as well as immunotherapy of the disease. |
| first_indexed | 2024-03-12T07:47:34Z |
| format | Article |
| id | doaj.art-2aa3b9fc80d1426c921241925a4940a2 |
| institution | Directory Open Access Journal |
| issn | 0042-4609 2313-6294 |
| language | English |
| last_indexed | 2024-03-12T07:47:34Z |
| publishDate | 2017-08-01 |
| publisher | State Scientific Center of Dermatovenereology and Cosmetology |
| record_format | Article |
| series | Vestnik Dermatologii i Venerologii |
| spelling | doaj.art-2aa3b9fc80d1426c921241925a4940a22023-09-02T20:51:32ZengState Scientific Center of Dermatovenereology and CosmetologyVestnik Dermatologii i Venerologii0042-46092313-62942017-08-0104121910.25208/0042-4609-2016-0-4-12-19251Drug therapy of leprosyA. A. Kubanov0A. E. Karamova1A. A. Vorontsova2P. A. Kalinina3ФГБУ «Государственный научный центр дерматовенерологии и косметологии» Минздрава России; ГБОУ ДПО «Российская медицинская академия последипломного образования» Минздрава РоссииФГБУ «Государственный научный центр дерматовенерологии и косметологии» Минздрава РоссииФГБУ «Государственный научный центр дерматовенерологии и косметологии» Минздрава РоссииГБОУ ДПО «Российская медицинская академия последипломного образования» Минздрава РоссииLeprosy (Hansen’s disease) is a chronic granulomatous bacterial infection mainly affecting the skin and peripheral nervous system yet also involving other organs and systems as a result of a pathological process. The causative agent of leprosy - Mycobacterium leprae - is an obligate intracellular microorganism. Despite the removal of a threat of a leprosy epidemic, European countries still record outbreaks of the disease mainly among migrants coming from endemic areas. A golden standard of the treatment of leprosy is a WHO-recommended combined drug therapy comprising drugs such as dapsone, clofazimine and rifampicin. The article provides current data on the mechanisms of action, efficacy and safety of these drugs and their combined scheme of treatment obtained as a result of clinical trials. Moreover, it also reviews new regimens of the drug therapy of leprosy including those with the use of drugs from the group of fluoroquinols as well as immunotherapy of the disease.https://www.vestnikdv.ru/jour/article/view/252лепракомбинированная лекарственная терапияmycobacterium lepraeleprosycombined drug therapymycobacterium leprae |
| spellingShingle | A. A. Kubanov A. E. Karamova A. A. Vorontsova P. A. Kalinina Drug therapy of leprosy Vestnik Dermatologii i Venerologii лепра комбинированная лекарственная терапия mycobacterium leprae leprosy combined drug therapy mycobacterium leprae |
| title | Drug therapy of leprosy |
| title_full | Drug therapy of leprosy |
| title_fullStr | Drug therapy of leprosy |
| title_full_unstemmed | Drug therapy of leprosy |
| title_short | Drug therapy of leprosy |
| title_sort | drug therapy of leprosy |
| topic | лепра комбинированная лекарственная терапия mycobacterium leprae leprosy combined drug therapy mycobacterium leprae |
| url | https://www.vestnikdv.ru/jour/article/view/252 |
| work_keys_str_mv | AT aakubanov drugtherapyofleprosy AT aekaramova drugtherapyofleprosy AT aavorontsova drugtherapyofleprosy AT pakalinina drugtherapyofleprosy |