Aggregation of Gold Nanoparticles for Spectrophotometric Determination of Bisoprolol Hemifumarate, Buspirone HCl and Doxazosin Mesylate
A simple, rapid and sensitive spectrophotometric method was developed for determination of bisoprolol hemifumarate, buspirone HCl and doxazosin mesylate in pure form and in pharmaceutical formulations. The method was based on aggregation of synthesized gold nanoparticles (Au NPs). Gold nanoparticles...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2019-03-01
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| Series: | Nano Biomedicine and Engineering |
| Subjects: | |
| Online Access: | https://www.sciopen.com/article/10.5101/nbe.v11i1.p1-10 |
| _version_ | 1797673359954149376 |
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| author | Magda Mohamed Ayad Hisham Ezzat Abdellatef Mervat Mohamed Hosny Naglaa Abdel-Sattar Kabil |
| author_facet | Magda Mohamed Ayad Hisham Ezzat Abdellatef Mervat Mohamed Hosny Naglaa Abdel-Sattar Kabil |
| author_sort | Magda Mohamed Ayad |
| collection | DOAJ |
| description | A simple, rapid and sensitive spectrophotometric method was developed for determination of bisoprolol hemifumarate, buspirone HCl and doxazosin mesylate in pure form and in pharmaceutical formulations. The method was based on aggregation of synthesized gold nanoparticles (Au NPs). Gold nanoparticles showed an absorption band at 520 nm. Upon interaction with the cited drugs, the band at 520 nm disappeared with formation of a new red shifted band at 616, 656 and 670 nm for doxazosin mesylate, bisoprolol hemifumarate and buspirone HCl, respectively. Different experimental factors were optimized for higher sensitivity. The calibration curves were linear with concentrations of 3-14, 0.1-1.2 and 0.2-1.0 μg/mL for bisoprolol hemifumarate, buspirone HCl and doxazosin mesylate, respectively. The method was applied successfully to determine the studied drugs in minor concentrations in pure form and in their pharmaceutical dosage forms. |
| first_indexed | 2024-03-11T21:43:23Z |
| format | Article |
| id | doaj.art-2aa4bf3949bc4a36b91765c137baa2d8 |
| institution | Directory Open Access Journal |
| issn | 2150-5578 |
| language | English |
| last_indexed | 2024-03-11T21:43:23Z |
| publishDate | 2019-03-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Nano Biomedicine and Engineering |
| spelling | doaj.art-2aa4bf3949bc4a36b91765c137baa2d82023-09-26T11:02:56ZengTsinghua University PressNano Biomedicine and Engineering2150-55782019-03-0111111010.5101/nbe.v11i1.p1-10Aggregation of Gold Nanoparticles for Spectrophotometric Determination of Bisoprolol Hemifumarate, Buspirone HCl and Doxazosin MesylateMagda Mohamed Ayad0Hisham Ezzat Abdellatef1Mervat Mohamed Hosny2Naglaa Abdel-Sattar Kabil3Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, EgyptAnalytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, EgyptAnalytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, EgyptAnalytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, EgyptA simple, rapid and sensitive spectrophotometric method was developed for determination of bisoprolol hemifumarate, buspirone HCl and doxazosin mesylate in pure form and in pharmaceutical formulations. The method was based on aggregation of synthesized gold nanoparticles (Au NPs). Gold nanoparticles showed an absorption band at 520 nm. Upon interaction with the cited drugs, the band at 520 nm disappeared with formation of a new red shifted band at 616, 656 and 670 nm for doxazosin mesylate, bisoprolol hemifumarate and buspirone HCl, respectively. Different experimental factors were optimized for higher sensitivity. The calibration curves were linear with concentrations of 3-14, 0.1-1.2 and 0.2-1.0 μg/mL for bisoprolol hemifumarate, buspirone HCl and doxazosin mesylate, respectively. The method was applied successfully to determine the studied drugs in minor concentrations in pure form and in their pharmaceutical dosage forms.https://www.sciopen.com/article/10.5101/nbe.v11i1.p1-10gold nanoparticlesbisoprolol hemifumaratebuspirone hcldoxazosin mesylate |
| spellingShingle | Magda Mohamed Ayad Hisham Ezzat Abdellatef Mervat Mohamed Hosny Naglaa Abdel-Sattar Kabil Aggregation of Gold Nanoparticles for Spectrophotometric Determination of Bisoprolol Hemifumarate, Buspirone HCl and Doxazosin Mesylate Nano Biomedicine and Engineering gold nanoparticles bisoprolol hemifumarate buspirone hcl doxazosin mesylate |
| title | Aggregation of Gold Nanoparticles for Spectrophotometric Determination of Bisoprolol Hemifumarate, Buspirone HCl and Doxazosin Mesylate |
| title_full | Aggregation of Gold Nanoparticles for Spectrophotometric Determination of Bisoprolol Hemifumarate, Buspirone HCl and Doxazosin Mesylate |
| title_fullStr | Aggregation of Gold Nanoparticles for Spectrophotometric Determination of Bisoprolol Hemifumarate, Buspirone HCl and Doxazosin Mesylate |
| title_full_unstemmed | Aggregation of Gold Nanoparticles for Spectrophotometric Determination of Bisoprolol Hemifumarate, Buspirone HCl and Doxazosin Mesylate |
| title_short | Aggregation of Gold Nanoparticles for Spectrophotometric Determination of Bisoprolol Hemifumarate, Buspirone HCl and Doxazosin Mesylate |
| title_sort | aggregation of gold nanoparticles for spectrophotometric determination of bisoprolol hemifumarate buspirone hcl and doxazosin mesylate |
| topic | gold nanoparticles bisoprolol hemifumarate buspirone hcl doxazosin mesylate |
| url | https://www.sciopen.com/article/10.5101/nbe.v11i1.p1-10 |
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