Deciphering the Role of microRNA Mediated Regulation of Coronin 1C in Glioblastoma Development and Metastasis
Glioblastoma multiforme (GBM) is a highly heterogenic and malignant brain tumour with a median survival of 15 months. The initial identification of primary glioblastomas is often challenging. Coronin 1C (CORO1C) is a key player in actin rearrangement and cofilin dynamics, as well as enhancing the pr...
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| Format: | Article |
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MDPI AG
2023-01-01
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| Series: | Non-Coding RNA |
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| Online Access: | https://www.mdpi.com/2311-553X/9/1/4 |
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| author | Denis Mustafov Emmanouil Karteris Maria Braoudaki |
| author_facet | Denis Mustafov Emmanouil Karteris Maria Braoudaki |
| author_sort | Denis Mustafov |
| collection | DOAJ |
| description | Glioblastoma multiforme (GBM) is a highly heterogenic and malignant brain tumour with a median survival of 15 months. The initial identification of primary glioblastomas is often challenging. Coronin 1C (CORO1C) is a key player in actin rearrangement and cofilin dynamics, as well as enhancing the processes of neurite overgrowth and migration of brain tumour cells. Different bioinformatic databases were accessed to measure CORO1C expression at the mRNA and protein level in normal and malignant brains. CORO1C expression was observed in brain regions which have retained high synaptic plasticity and myelination properties. CORO1C was also expressed mainly within the hippocampus formation, including the Cornu Ammonis (CA) fields: CA1–CA4. Higher expression was also noticed in paediatric GBM in comparison to their adult counterparts. Pediatric cell populations were observed to have an increased log2 expression of CORO1C. Furthermore, 62 miRNAs were found to target the CORO1C gene. Of these, hsa-miR-34a-5p, hsa-miR-512-3p, hsa-miR-136-5p, hsa-miR-206, hsa-miR-128-3p, and hsa-miR-21-5p have shown to act as tumour suppressors or oncomiRs in different neoplasms, including GBM. The elevated expression of CORO1C in high grade metastatic brain malignancies, including GBM, suggests that this protein could have a clinical utility as a biomarker linked to an unfavorable outcome. |
| first_indexed | 2024-03-11T08:19:40Z |
| format | Article |
| id | doaj.art-2aa64bb303c44ee98a7e34c7740e0e65 |
| institution | Directory Open Access Journal |
| issn | 2311-553X |
| language | English |
| last_indexed | 2024-03-11T08:19:40Z |
| publishDate | 2023-01-01 |
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| series | Non-Coding RNA |
| spelling | doaj.art-2aa64bb303c44ee98a7e34c7740e0e652023-11-16T22:28:54ZengMDPI AGNon-Coding RNA2311-553X2023-01-0191410.3390/ncrna9010004Deciphering the Role of microRNA Mediated Regulation of Coronin 1C in Glioblastoma Development and MetastasisDenis Mustafov0Emmanouil Karteris1Maria Braoudaki2School of Life and Medical Sciences, University of Hertfordshire, Hatfield AL10 9AB, UKCollege of Health, Medicine and Life Sciences, Brunel University London, Uxbridge UB8 3PH, UKSchool of Life and Medical Sciences, University of Hertfordshire, Hatfield AL10 9AB, UKGlioblastoma multiforme (GBM) is a highly heterogenic and malignant brain tumour with a median survival of 15 months. The initial identification of primary glioblastomas is often challenging. Coronin 1C (CORO1C) is a key player in actin rearrangement and cofilin dynamics, as well as enhancing the processes of neurite overgrowth and migration of brain tumour cells. Different bioinformatic databases were accessed to measure CORO1C expression at the mRNA and protein level in normal and malignant brains. CORO1C expression was observed in brain regions which have retained high synaptic plasticity and myelination properties. CORO1C was also expressed mainly within the hippocampus formation, including the Cornu Ammonis (CA) fields: CA1–CA4. Higher expression was also noticed in paediatric GBM in comparison to their adult counterparts. Pediatric cell populations were observed to have an increased log2 expression of CORO1C. Furthermore, 62 miRNAs were found to target the CORO1C gene. Of these, hsa-miR-34a-5p, hsa-miR-512-3p, hsa-miR-136-5p, hsa-miR-206, hsa-miR-128-3p, and hsa-miR-21-5p have shown to act as tumour suppressors or oncomiRs in different neoplasms, including GBM. The elevated expression of CORO1C in high grade metastatic brain malignancies, including GBM, suggests that this protein could have a clinical utility as a biomarker linked to an unfavorable outcome.https://www.mdpi.com/2311-553X/9/1/4CORO1CmRNAmicroRNA expressionbraincancerglioblastoma |
| spellingShingle | Denis Mustafov Emmanouil Karteris Maria Braoudaki Deciphering the Role of microRNA Mediated Regulation of Coronin 1C in Glioblastoma Development and Metastasis Non-Coding RNA CORO1C mRNA microRNA expression brain cancer glioblastoma |
| title | Deciphering the Role of microRNA Mediated Regulation of Coronin 1C in Glioblastoma Development and Metastasis |
| title_full | Deciphering the Role of microRNA Mediated Regulation of Coronin 1C in Glioblastoma Development and Metastasis |
| title_fullStr | Deciphering the Role of microRNA Mediated Regulation of Coronin 1C in Glioblastoma Development and Metastasis |
| title_full_unstemmed | Deciphering the Role of microRNA Mediated Regulation of Coronin 1C in Glioblastoma Development and Metastasis |
| title_short | Deciphering the Role of microRNA Mediated Regulation of Coronin 1C in Glioblastoma Development and Metastasis |
| title_sort | deciphering the role of microrna mediated regulation of coronin 1c in glioblastoma development and metastasis |
| topic | CORO1C mRNA microRNA expression brain cancer glioblastoma |
| url | https://www.mdpi.com/2311-553X/9/1/4 |
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