Resolving DNA Damage: Epigenetic Regulation of DNA Repair
Epigenetic research has rapidly evolved into a dynamic field of genome biology. Chromatin regulation has been proved to be an essential aspect for all genomic processes, including DNA repair. Chromatin structure is modified by enzymes and factors that deposit, erase, and interact with epigenetic mar...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-05-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/25/11/2496 |
| _version_ | 1797566865768185856 |
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| author | Panagiotis Karakaidos Dimitris Karagiannis Theodoros Rampias |
| author_facet | Panagiotis Karakaidos Dimitris Karagiannis Theodoros Rampias |
| author_sort | Panagiotis Karakaidos |
| collection | DOAJ |
| description | Epigenetic research has rapidly evolved into a dynamic field of genome biology. Chromatin regulation has been proved to be an essential aspect for all genomic processes, including DNA repair. Chromatin structure is modified by enzymes and factors that deposit, erase, and interact with epigenetic marks such as DNA and histone modifications, as well as by complexes that remodel nucleosomes. In this review we discuss recent advances on how the chromatin state is modulated during this multi-step process of damage recognition, signaling, and repair. Moreover, we examine how chromatin is regulated when different pathways of DNA repair are utilized. Furthermore, we review additional modes of regulation of DNA repair, such as through the role of global and localized chromatin states in maintaining expression of DNA repair genes, as well as through the activity of epigenetic enzymes on non-nucleosome substrates. Finally, we discuss current and future applications of the mechanistic interplays between chromatin regulation and DNA repair in the context cancer treatment. |
| first_indexed | 2024-03-10T19:32:28Z |
| format | Article |
| id | doaj.art-2aa6842226e84499a3d64b3bc9bb3686 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T19:32:28Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-2aa6842226e84499a3d64b3bc9bb36862023-11-20T01:57:43ZengMDPI AGMolecules1420-30492020-05-012511249610.3390/molecules25112496Resolving DNA Damage: Epigenetic Regulation of DNA RepairPanagiotis Karakaidos0Dimitris Karagiannis1Theodoros Rampias2Biomedical Research Foundation of the Academy of Athens, 11527 Athens, GreeceDepartment of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USABiomedical Research Foundation of the Academy of Athens, 11527 Athens, GreeceEpigenetic research has rapidly evolved into a dynamic field of genome biology. Chromatin regulation has been proved to be an essential aspect for all genomic processes, including DNA repair. Chromatin structure is modified by enzymes and factors that deposit, erase, and interact with epigenetic marks such as DNA and histone modifications, as well as by complexes that remodel nucleosomes. In this review we discuss recent advances on how the chromatin state is modulated during this multi-step process of damage recognition, signaling, and repair. Moreover, we examine how chromatin is regulated when different pathways of DNA repair are utilized. Furthermore, we review additional modes of regulation of DNA repair, such as through the role of global and localized chromatin states in maintaining expression of DNA repair genes, as well as through the activity of epigenetic enzymes on non-nucleosome substrates. Finally, we discuss current and future applications of the mechanistic interplays between chromatin regulation and DNA repair in the context cancer treatment.https://www.mdpi.com/1420-3049/25/11/2496DNA damageDNA repairepigenomicschromatin remodeling |
| spellingShingle | Panagiotis Karakaidos Dimitris Karagiannis Theodoros Rampias Resolving DNA Damage: Epigenetic Regulation of DNA Repair Molecules DNA damage DNA repair epigenomics chromatin remodeling |
| title | Resolving DNA Damage: Epigenetic Regulation of DNA Repair |
| title_full | Resolving DNA Damage: Epigenetic Regulation of DNA Repair |
| title_fullStr | Resolving DNA Damage: Epigenetic Regulation of DNA Repair |
| title_full_unstemmed | Resolving DNA Damage: Epigenetic Regulation of DNA Repair |
| title_short | Resolving DNA Damage: Epigenetic Regulation of DNA Repair |
| title_sort | resolving dna damage epigenetic regulation of dna repair |
| topic | DNA damage DNA repair epigenomics chromatin remodeling |
| url | https://www.mdpi.com/1420-3049/25/11/2496 |
| work_keys_str_mv | AT panagiotiskarakaidos resolvingdnadamageepigeneticregulationofdnarepair AT dimitriskaragiannis resolvingdnadamageepigeneticregulationofdnarepair AT theodorosrampias resolvingdnadamageepigeneticregulationofdnarepair |