Acquired Hyperzincaemia Due to Zinc-Laden Denture Adhesives Leading to Hypocupraemia as a Cause of Neutropenia
Introduction: Copper deficiency or hypocupraemia is a rare cause of anaemia and neutropenia. Case description: We hereby present the case of a 34-year-old female with gastric bypass surgery who presented with neutropenic fever, abdominal pain and diarrhoea, later found to have extended-spectrum bet...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SMC MEDIA SRL
2021-11-01
|
| Series: | European Journal of Case Reports in Internal Medicine |
| Subjects: | |
| Online Access: | https://www.ejcrim.com/index.php/EJCRIM/article/view/2983 |
| _version_ | 1818352954185351168 |
|---|---|
| author | FNU Amisha Prachi Saluja Nitesh Gautam Shubham Biyani Sunilkumar Kakadia |
| author_facet | FNU Amisha Prachi Saluja Nitesh Gautam Shubham Biyani Sunilkumar Kakadia |
| author_sort | FNU Amisha |
| collection | DOAJ |
| description | Introduction: Copper deficiency or hypocupraemia is a rare cause of anaemia and neutropenia.
Case description: We hereby present the case of a 34-year-old female with gastric bypass surgery who presented with neutropenic fever, abdominal pain and diarrhoea, later found to have extended-spectrum beta-lactamase resistant Escherichia coli urinary tract infection and small bowel bacterial overgrowth syndrome, with her anaemia and neutropenia being caused by copper deficiency due to hyperzincaemia induced by using zinc denture adhesive cream.
Discussion: Various causes of copper deficiency have been recognized including, but not limited to, malnutrition, gastrectomy, gastric bypass surgery, protein-losing enteropathies (coeliac disease, tropical sprue), Wilson disease and Menkes syndrome. Copper deficiency caused by zinc overuse is not very prevalent. The haematologic abnormalities associated with copper deficiency are neutropenia, sideroblastic anaemia and/or pancytopenia.
Conclusion: Because of its low prevalence and nonspecific haematologic and clinical manifestations, the diagnosis of zinc-induced copper deficiency (ZICD) can be missed. |
| first_indexed | 2024-12-13T19:01:50Z |
| format | Article |
| id | doaj.art-2aa6ded66cf24042b07d229cd7822c62 |
| institution | Directory Open Access Journal |
| issn | 2284-2594 |
| language | English |
| last_indexed | 2024-12-13T19:01:50Z |
| publishDate | 2021-11-01 |
| publisher | SMC MEDIA SRL |
| record_format | Article |
| series | European Journal of Case Reports in Internal Medicine |
| spelling | doaj.art-2aa6ded66cf24042b07d229cd7822c622022-12-21T23:34:40ZengSMC MEDIA SRLEuropean Journal of Case Reports in Internal Medicine2284-25942021-11-0110.12890/2021_0029832518Acquired Hyperzincaemia Due to Zinc-Laden Denture Adhesives Leading to Hypocupraemia as a Cause of NeutropeniaFNU Amisha0Prachi Saluja1Nitesh Gautam2Shubham Biyani3Sunilkumar Kakadia4Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United StatesDepartment of Neurology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United StatesUniversity of Arkansas for Medical Sciences, Little Rock, Arkansas, Unites States.Introduction: Copper deficiency or hypocupraemia is a rare cause of anaemia and neutropenia. Case description: We hereby present the case of a 34-year-old female with gastric bypass surgery who presented with neutropenic fever, abdominal pain and diarrhoea, later found to have extended-spectrum beta-lactamase resistant Escherichia coli urinary tract infection and small bowel bacterial overgrowth syndrome, with her anaemia and neutropenia being caused by copper deficiency due to hyperzincaemia induced by using zinc denture adhesive cream. Discussion: Various causes of copper deficiency have been recognized including, but not limited to, malnutrition, gastrectomy, gastric bypass surgery, protein-losing enteropathies (coeliac disease, tropical sprue), Wilson disease and Menkes syndrome. Copper deficiency caused by zinc overuse is not very prevalent. The haematologic abnormalities associated with copper deficiency are neutropenia, sideroblastic anaemia and/or pancytopenia. Conclusion: Because of its low prevalence and nonspecific haematologic and clinical manifestations, the diagnosis of zinc-induced copper deficiency (ZICD) can be missed.https://www.ejcrim.com/index.php/EJCRIM/article/view/2983zinc toxicitypancytopeniacopper deficiencyanaemianeutropenia |
| spellingShingle | FNU Amisha Prachi Saluja Nitesh Gautam Shubham Biyani Sunilkumar Kakadia Acquired Hyperzincaemia Due to Zinc-Laden Denture Adhesives Leading to Hypocupraemia as a Cause of Neutropenia European Journal of Case Reports in Internal Medicine zinc toxicity pancytopenia copper deficiency anaemia neutropenia |
| title | Acquired Hyperzincaemia Due to Zinc-Laden Denture Adhesives Leading to Hypocupraemia as a Cause of Neutropenia |
| title_full | Acquired Hyperzincaemia Due to Zinc-Laden Denture Adhesives Leading to Hypocupraemia as a Cause of Neutropenia |
| title_fullStr | Acquired Hyperzincaemia Due to Zinc-Laden Denture Adhesives Leading to Hypocupraemia as a Cause of Neutropenia |
| title_full_unstemmed | Acquired Hyperzincaemia Due to Zinc-Laden Denture Adhesives Leading to Hypocupraemia as a Cause of Neutropenia |
| title_short | Acquired Hyperzincaemia Due to Zinc-Laden Denture Adhesives Leading to Hypocupraemia as a Cause of Neutropenia |
| title_sort | acquired hyperzincaemia due to zinc laden denture adhesives leading to hypocupraemia as a cause of neutropenia |
| topic | zinc toxicity pancytopenia copper deficiency anaemia neutropenia |
| url | https://www.ejcrim.com/index.php/EJCRIM/article/view/2983 |
| work_keys_str_mv | AT fnuamisha acquiredhyperzincaemiaduetozincladendentureadhesivesleadingtohypocupraemiaasacauseofneutropenia AT prachisaluja acquiredhyperzincaemiaduetozincladendentureadhesivesleadingtohypocupraemiaasacauseofneutropenia AT niteshgautam acquiredhyperzincaemiaduetozincladendentureadhesivesleadingtohypocupraemiaasacauseofneutropenia AT shubhambiyani acquiredhyperzincaemiaduetozincladendentureadhesivesleadingtohypocupraemiaasacauseofneutropenia AT sunilkumarkakadia acquiredhyperzincaemiaduetozincladendentureadhesivesleadingtohypocupraemiaasacauseofneutropenia |