Distinct Neural Circuits Underlie Prospective and Concurrent Memory-Guided Behavior
Summary: The past is the best predictor of the future. This simple postulate belies the complex neurobiological mechanisms that facilitate an individual’s use of memory to guide decisions. Previous research has shown integration of memories bias decision-making. Alternatively, memories can prospecti...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-09-01
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| Series: | Cell Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124719310253 |
| _version_ | 1817993959084916736 |
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| author | Amanda G. Hamm Aaron T. Mattfeld |
| author_facet | Amanda G. Hamm Aaron T. Mattfeld |
| author_sort | Amanda G. Hamm |
| collection | DOAJ |
| description | Summary: The past is the best predictor of the future. This simple postulate belies the complex neurobiological mechanisms that facilitate an individual’s use of memory to guide decisions. Previous research has shown integration of memories bias decision-making. Alternatively, memories can prospectively guide our choices. Here, we elucidate the mechanisms and timing of hippocampal (HPC), medial prefrontal cortex (mPFC), and striatal contributions during prospective memory-guided decision-making. We develop an associative learning task in which the correct choice is conditional on the preceding stimulus. Two distinct networks emerge: (1) a prospective circuit consisting of the HPC, putamen, mPFC, and other cortical regions, which exhibit increased activation preceding successful conditional decisions and (2) a concurrent circuit comprising the caudate, dorsolateral prefrontal cortex (dlPFC), and additional cortical structures that engage during the execution of correct conditional choices. Our findings demonstrate distinct neurobiological circuits through which memory prospectively biases decisions and influences choice execution. : Hamm and Mattfeld use fMRI to demonstrate that greater activations in the hippocampus, medial prefrontal cortex, putamen, and other regions (prospective network) precede successful conditional decisions. In contrast, greater activations in the caudate, dorsolateral prefrontal cortex, and other regions (concurrent network) are associated with the execution of successful conditional behavior. Keywords: hippocampus, medial prefrontal cortex, striatum, putamen, caudate, fMRI, memory, decision-making |
| first_indexed | 2024-04-14T01:46:42Z |
| format | Article |
| id | doaj.art-2aa83577d46047869326162df6aafe29 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-04-14T01:46:42Z |
| publishDate | 2019-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-2aa83577d46047869326162df6aafe292022-12-22T02:19:30ZengElsevierCell Reports2211-12472019-09-01281025412553.e4Distinct Neural Circuits Underlie Prospective and Concurrent Memory-Guided BehaviorAmanda G. Hamm0Aaron T. Mattfeld1Cognitive Neuroscience Program, Department of Psychology, Florida International University, Miami, FL 33199, USACognitive Neuroscience Program, Department of Psychology, Florida International University, Miami, FL 33199, USA; Center for Children and Families, Florida International University, Miami, FL 33199, USA; Corresponding authorSummary: The past is the best predictor of the future. This simple postulate belies the complex neurobiological mechanisms that facilitate an individual’s use of memory to guide decisions. Previous research has shown integration of memories bias decision-making. Alternatively, memories can prospectively guide our choices. Here, we elucidate the mechanisms and timing of hippocampal (HPC), medial prefrontal cortex (mPFC), and striatal contributions during prospective memory-guided decision-making. We develop an associative learning task in which the correct choice is conditional on the preceding stimulus. Two distinct networks emerge: (1) a prospective circuit consisting of the HPC, putamen, mPFC, and other cortical regions, which exhibit increased activation preceding successful conditional decisions and (2) a concurrent circuit comprising the caudate, dorsolateral prefrontal cortex (dlPFC), and additional cortical structures that engage during the execution of correct conditional choices. Our findings demonstrate distinct neurobiological circuits through which memory prospectively biases decisions and influences choice execution. : Hamm and Mattfeld use fMRI to demonstrate that greater activations in the hippocampus, medial prefrontal cortex, putamen, and other regions (prospective network) precede successful conditional decisions. In contrast, greater activations in the caudate, dorsolateral prefrontal cortex, and other regions (concurrent network) are associated with the execution of successful conditional behavior. Keywords: hippocampus, medial prefrontal cortex, striatum, putamen, caudate, fMRI, memory, decision-makinghttp://www.sciencedirect.com/science/article/pii/S2211124719310253 |
| spellingShingle | Amanda G. Hamm Aaron T. Mattfeld Distinct Neural Circuits Underlie Prospective and Concurrent Memory-Guided Behavior Cell Reports |
| title | Distinct Neural Circuits Underlie Prospective and Concurrent Memory-Guided Behavior |
| title_full | Distinct Neural Circuits Underlie Prospective and Concurrent Memory-Guided Behavior |
| title_fullStr | Distinct Neural Circuits Underlie Prospective and Concurrent Memory-Guided Behavior |
| title_full_unstemmed | Distinct Neural Circuits Underlie Prospective and Concurrent Memory-Guided Behavior |
| title_short | Distinct Neural Circuits Underlie Prospective and Concurrent Memory-Guided Behavior |
| title_sort | distinct neural circuits underlie prospective and concurrent memory guided behavior |
| url | http://www.sciencedirect.com/science/article/pii/S2211124719310253 |
| work_keys_str_mv | AT amandaghamm distinctneuralcircuitsunderlieprospectiveandconcurrentmemoryguidedbehavior AT aarontmattfeld distinctneuralcircuitsunderlieprospectiveandconcurrentmemoryguidedbehavior |