Effects of gallic acid and physical exercise on passive avoidance memory in male rat
Learning and memory play main roles in daily life of human, and memory represents the basis of all trainings and learning. The aim of the current study is to investigate the effects of gallic acid and physical exercise on the levels of passive avoidance memory in rat. In this experimental study, 46...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Universidade de São Paulo
2019-10-01
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| Series: | Brazilian Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100568&tlng=en |
| _version_ | 1811271336774860800 |
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| author | Azadeh Salehi Zahra Rabiei Mahbubeh Setorki |
| author_facet | Azadeh Salehi Zahra Rabiei Mahbubeh Setorki |
| author_sort | Azadeh Salehi |
| collection | DOAJ |
| description | Learning and memory play main roles in daily life of human, and memory represents the basis of all trainings and learning. The aim of the current study is to investigate the effects of gallic acid and physical exercise on the levels of passive avoidance memory in rat. In this experimental study, 46 rats weighing 200-300 g were randomLy divided to six groups of eight each: including control group, groups treated with 10 and 20 mg/kg gallic acid, group undergoing physical exercise alone, and groups both undergoing physical exercise and treated with 10 and 20 mg/kg gallic acid. The interventions continued for 10 days. After the intervention, passive avoidance memory was measured by shuttle box, blood samples were taken, and serum and brain antioxidant capacity and malondialdehyde (MDA) levels were measured. Secondary latency in shuttle box significantly increased in groups undergoing treadmill exercise and undergoing treadmill exercise + treating 10 and 20 mg/kg gallic acid. In groups treated with 10 and 20 mg/kg gallic acid alone, secondary latency increased significantly. Results confirmed the effects of gallic acid and physical exercise, either alone or combined, in improving memory. |
| first_indexed | 2024-04-12T22:18:15Z |
| format | Article |
| id | doaj.art-2aaac21bf4d4456b96b5b03731777de7 |
| institution | Directory Open Access Journal |
| issn | 2175-9790 |
| language | English |
| last_indexed | 2024-04-12T22:18:15Z |
| publishDate | 2019-10-01 |
| publisher | Universidade de São Paulo |
| record_format | Article |
| series | Brazilian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-2aaac21bf4d4456b96b5b03731777de72022-12-22T03:14:26ZengUniversidade de São PauloBrazilian Journal of Pharmaceutical Sciences2175-97902019-10-015510.1590/s2175-97902019000218261Effects of gallic acid and physical exercise on passive avoidance memory in male ratAzadeh SalehiZahra RabieiMahbubeh Setorkihttps://orcid.org/0000-0001-6983-9929Learning and memory play main roles in daily life of human, and memory represents the basis of all trainings and learning. The aim of the current study is to investigate the effects of gallic acid and physical exercise on the levels of passive avoidance memory in rat. In this experimental study, 46 rats weighing 200-300 g were randomLy divided to six groups of eight each: including control group, groups treated with 10 and 20 mg/kg gallic acid, group undergoing physical exercise alone, and groups both undergoing physical exercise and treated with 10 and 20 mg/kg gallic acid. The interventions continued for 10 days. After the intervention, passive avoidance memory was measured by shuttle box, blood samples were taken, and serum and brain antioxidant capacity and malondialdehyde (MDA) levels were measured. Secondary latency in shuttle box significantly increased in groups undergoing treadmill exercise and undergoing treadmill exercise + treating 10 and 20 mg/kg gallic acid. In groups treated with 10 and 20 mg/kg gallic acid alone, secondary latency increased significantly. Results confirmed the effects of gallic acid and physical exercise, either alone or combined, in improving memory.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100568&tlng=enGallic Acid/adverse effectsLearning/drug effectsMemory/drug effectsPhysical Exercise/physiologyMDAAvoidance Learning/drug effectsExercise/physiologyRats/physiologyMalondialdehyde/analysis |
| spellingShingle | Azadeh Salehi Zahra Rabiei Mahbubeh Setorki Effects of gallic acid and physical exercise on passive avoidance memory in male rat Brazilian Journal of Pharmaceutical Sciences Gallic Acid/adverse effects Learning/drug effects Memory/drug effects Physical Exercise/physiology MDA Avoidance Learning/drug effects Exercise/physiology Rats/physiology Malondialdehyde/analysis |
| title | Effects of gallic acid and physical exercise on passive avoidance memory in male rat |
| title_full | Effects of gallic acid and physical exercise on passive avoidance memory in male rat |
| title_fullStr | Effects of gallic acid and physical exercise on passive avoidance memory in male rat |
| title_full_unstemmed | Effects of gallic acid and physical exercise on passive avoidance memory in male rat |
| title_short | Effects of gallic acid and physical exercise on passive avoidance memory in male rat |
| title_sort | effects of gallic acid and physical exercise on passive avoidance memory in male rat |
| topic | Gallic Acid/adverse effects Learning/drug effects Memory/drug effects Physical Exercise/physiology MDA Avoidance Learning/drug effects Exercise/physiology Rats/physiology Malondialdehyde/analysis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100568&tlng=en |
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