Efficacy and safety of Panax ginseng berry extract on glycemic control: A 12-wk randomized, double-blind, and placebo-controlled clinical trial
Background: Antihyperglycemic effects of Panax ginseng berry have never been explored in humans. The aims of this study were to assess the efficacy and safety of a 12-wk treatment with ginseng berry extract in participants with a fasting glucose level between 100 mg/dL and 140 mg/dL. Methods: This s...
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| Format: | Article |
| Language: | English |
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Elsevier
2018-01-01
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| Series: | Journal of Ginseng Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1226845316300306 |
| _version_ | 1818127329015103488 |
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| author | Han Seok Choi Sunmi Kim Min Jung Kim Myung-Sunny Kim Juewon Kim Chan-Woong Park Daebang Seo Song Seok Shin Sang Woo Oh |
| author_facet | Han Seok Choi Sunmi Kim Min Jung Kim Myung-Sunny Kim Juewon Kim Chan-Woong Park Daebang Seo Song Seok Shin Sang Woo Oh |
| author_sort | Han Seok Choi |
| collection | DOAJ |
| description | Background: Antihyperglycemic effects of Panax ginseng berry have never been explored in humans. The aims of this study were to assess the efficacy and safety of a 12-wk treatment with ginseng berry extract in participants with a fasting glucose level between 100 mg/dL and 140 mg/dL.
Methods: This study was a 12-wk, randomized, double-blind, placebo-controlled clinical trial. A total of 72 participants were randomly allocated to two groups of either ginseng berry extract or placebo, and 63 participants completed the study. The parameters related to glucose metabolism were assessed.
Results: Although the present study failed to show significant antihyperglycemic effects of ginseng berry extract on the parameters related to blood glucose and lipid metabolism in the total study population, it demonstrated that ginseng berry extract could significantly decrease serum concentration of fasting glucose by 3.7% (p = 0.035), postprandial glucose at 60 min during 75 g oral glucose tolerance test by 10.7% (p = 0.006), and the area under the curve for glucose by 7.7% (p = 0.024) in those with fasting glucose level of 110 mg/dL or higher, while the placebo group did not exhibit a statistically significant decrease. Safety profiles were not different between the two groups.
Conclusion: The present study suggests that ginseng berry extract has the potential to improve glucose metabolism in human, especially in those with fasting glucose level of 110 mg/dL or higher. For a more meaningful benefit, further research in people with higher blood glucose levels is required. |
| first_indexed | 2024-12-11T07:15:37Z |
| format | Article |
| id | doaj.art-2aab2ccd7c4f44a99f9060f8f5d119bf |
| institution | Directory Open Access Journal |
| issn | 1226-8453 |
| language | English |
| last_indexed | 2024-12-11T07:15:37Z |
| publishDate | 2018-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Ginseng Research |
| spelling | doaj.art-2aab2ccd7c4f44a99f9060f8f5d119bf2022-12-22T01:16:14ZengElsevierJournal of Ginseng Research1226-84532018-01-01421909710.1016/j.jgr.2017.01.003Efficacy and safety of Panax ginseng berry extract on glycemic control: A 12-wk randomized, double-blind, and placebo-controlled clinical trialHan Seok Choi0Sunmi Kim1Min Jung Kim2Myung-Sunny Kim3Juewon Kim4Chan-Woong Park5Daebang Seo6Song Seok Shin7Sang Woo Oh8Division of Endocrinology and Metabolism, Department of Internal Medicine, Dongguk University Ilsan Hospital, Goyang, Gyeonggi, Republic of KoreaResearch and Development Center, Amorepacific Corporation, Yongin, Gyeonggi, Republic of KoreaNutrition and Metabolism Research Group, Korea Food Research Institute, Seongnam, Gyeonggi-do, Republic of KoreaNutrition and Metabolism Research Group, Korea Food Research Institute, Seongnam, Gyeonggi-do, Republic of KoreaResearch and Development Center, Amorepacific Corporation, Yongin, Gyeonggi, Republic of KoreaResearch and Development Center, Amorepacific Corporation, Yongin, Gyeonggi, Republic of KoreaResearch and Development Center, Amorepacific Corporation, Yongin, Gyeonggi, Republic of KoreaResearch and Development Center, Amorepacific Corporation, Yongin, Gyeonggi, Republic of KoreaDepartment of Family Medicine, Dongguk University Ilsan Hospital, Goyang, Gyeonggi, Republic of KoreaBackground: Antihyperglycemic effects of Panax ginseng berry have never been explored in humans. The aims of this study were to assess the efficacy and safety of a 12-wk treatment with ginseng berry extract in participants with a fasting glucose level between 100 mg/dL and 140 mg/dL. Methods: This study was a 12-wk, randomized, double-blind, placebo-controlled clinical trial. A total of 72 participants were randomly allocated to two groups of either ginseng berry extract or placebo, and 63 participants completed the study. The parameters related to glucose metabolism were assessed. Results: Although the present study failed to show significant antihyperglycemic effects of ginseng berry extract on the parameters related to blood glucose and lipid metabolism in the total study population, it demonstrated that ginseng berry extract could significantly decrease serum concentration of fasting glucose by 3.7% (p = 0.035), postprandial glucose at 60 min during 75 g oral glucose tolerance test by 10.7% (p = 0.006), and the area under the curve for glucose by 7.7% (p = 0.024) in those with fasting glucose level of 110 mg/dL or higher, while the placebo group did not exhibit a statistically significant decrease. Safety profiles were not different between the two groups. Conclusion: The present study suggests that ginseng berry extract has the potential to improve glucose metabolism in human, especially in those with fasting glucose level of 110 mg/dL or higher. For a more meaningful benefit, further research in people with higher blood glucose levels is required.http://www.sciencedirect.com/science/article/pii/S1226845316300306antihyperglycemic effectsclinical trialglucose metabolismoral glucose tolerance testPanax ginseng berry |
| spellingShingle | Han Seok Choi Sunmi Kim Min Jung Kim Myung-Sunny Kim Juewon Kim Chan-Woong Park Daebang Seo Song Seok Shin Sang Woo Oh Efficacy and safety of Panax ginseng berry extract on glycemic control: A 12-wk randomized, double-blind, and placebo-controlled clinical trial Journal of Ginseng Research antihyperglycemic effects clinical trial glucose metabolism oral glucose tolerance test Panax ginseng berry |
| title | Efficacy and safety of Panax ginseng berry extract on glycemic control: A 12-wk randomized, double-blind, and placebo-controlled clinical trial |
| title_full | Efficacy and safety of Panax ginseng berry extract on glycemic control: A 12-wk randomized, double-blind, and placebo-controlled clinical trial |
| title_fullStr | Efficacy and safety of Panax ginseng berry extract on glycemic control: A 12-wk randomized, double-blind, and placebo-controlled clinical trial |
| title_full_unstemmed | Efficacy and safety of Panax ginseng berry extract on glycemic control: A 12-wk randomized, double-blind, and placebo-controlled clinical trial |
| title_short | Efficacy and safety of Panax ginseng berry extract on glycemic control: A 12-wk randomized, double-blind, and placebo-controlled clinical trial |
| title_sort | efficacy and safety of panax ginseng berry extract on glycemic control a 12 wk randomized double blind and placebo controlled clinical trial |
| topic | antihyperglycemic effects clinical trial glucose metabolism oral glucose tolerance test Panax ginseng berry |
| url | http://www.sciencedirect.com/science/article/pii/S1226845316300306 |
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