Thyroid cancer in a patient with a germline <it>MSH2 </it>mutation. Case report and review of the Lynch syndrome expanding tumour spectrum

Thyroid cancer in a patient with a germline <it>MSH2 </it>mutation. Case report and review of the Lynch syndrome expanding tumour spectrum

<p>Abstract</p> <p>Lynch syndrome (HNPCC) is a dominantly inherited disorder characterized by germline defects in DNA mismatch repair (MMR) genes and the development of a variety of cancers, predominantly colorectal and endometrial. We present a 44-year-old woman who was shown to c...

Bibliografske podrobnosti
Main Authors:	Stulp Rein P, Herkert Johanna C, Karrenbeld Arend, Mol Bart, Vos Yvonne J, Sijmons Rolf H
Format:	Article
Jezik:	English
Izdano:	BMC 2008-02-01
Serija:	Hereditary Cancer in Clinical Practice
Teme:	Lynch syndrome mutations <it>MSH2</it> thyroid cancer
Online dostop:	http://www.hccpjournal.com/content/6/1/15

Podobne knjige/članki

Novel germline <it>MSH2 </it>mutation in lynch syndrome patient surviving multiple cancers
od: Janavicius Ramunas, et al.
Izdano: (2012-01-01)

MSH6 germline mutations leading to Lynch syndrome-associated cholangiocarcinoma: a case report
od: Zheng Zhang, et al.
Izdano: (2024-08-01)

The MSH2 c.793-1G>A variant disrupts normal splicing and is associated with Lynch syndrome
od: Yiming Li, et al.
Izdano: (2023-07-01)

Primary malignant pericardial tumour in Lynch syndrome
od: Pasquale Paolisso, et al.
Izdano: (2020-03-01)

Characterization of a germline variant MSH6 c.4001G > C in a Lynch syndrome family
od: Ciyu Yang, et al.
Izdano: (2023-02-01)

A Novel MSH6 Gene Variant in a Lynch Syndrome Patient with Lipomas
od: Ana Paula Giannoni, et al.
Izdano: (2023-04-01)

Lynch syndrome-associated endometrial cancer patient with a rare novel germline likely pathogenic variant of MSH2 gene: A case report
od: L. Zumstein, et al.
Izdano: (2023-08-01)

Lynch Syndrome Germline Mutations in Breast Cancer: Next Generation Sequencing Case-Control Study of 1,263 Participants
od: Aleksey G. Nikitin, et al.
Izdano: (2020-05-01)

Papillary Renal Cell Carcinoma in Lynch/Muir-Torre Syndrome with Germline Pathogenic Variant in MSH6 and Molecular Analysis
od: Yu Yang, et al.
Izdano: (2021-04-01)

Clinicopathological features of Lynch syndrome pedigrees with MSH2 c.351G>A gene variant
od: Shuai Zhang, et al.
Izdano: (2025-01-01)

Rare single‐nucleotide variants of MLH1 and MSH2 genes in patients with Lynch syndrome
od: Seyed Mohsen Mirabdolhosseini, et al.
Izdano: (2024-01-01)

A case report: Gliosarcoma associated with a germline heterozygous mutation in MSH2
od: Yuhan Wang, et al.
Izdano: (2024-05-01)

Novel MSH2 Mutation in the First Report of a Vietnamese–American Kindred with Lynch Syndrome
od: Ramez N. Eskander, et al.
Izdano: (2015-04-01)

Germline MLH1 and MSH6 mutations from two Lynch syndrome families identified in a patient with early-onset of endometrial cancer: A case report
od: Yi-Ching Huang, et al.
Izdano: (2024-06-01)

A Novel Splice-Site Mutation in MSH2 Is Associated With the Development of Lynch Syndrome
od: Juyi Li, et al.
Izdano: (2020-06-01)

A new subtype of Lynch syndrome associated with MSH2 c.354T>A (p. Y118*) identified in a Chinese family: case report and literature review
od: Lan Zhong, et al.
Izdano: (2024-10-01)

Telomere Instability in Lynch Syndrome Families Leads to Some Shorter Telomeres in <i>MSH2+/-</i> Carriers
od: M. Carmen Garrido-Navas, et al.
Izdano: (2020-10-01)

Case report: Complete response to pembrolizumab in a liver metastatic colon adenocarcinoma patient with a novel likely pathogenic germline MSH2 mutation
od: Yanjie Xu, et al.
Izdano: (2022-11-01)

Gastric-type adenocarcinoma of the cervix in a patient with Lynch syndrome: A case report
od: M. Moat, et al.
Izdano: (2014-12-01)

Germline MLH1, MSH2 and MSH6 variants in Brazilian patients with colorectal cancer and clinical features suggestive of Lynch Syndrome
od: Nayê Balzan Schneider, et al.
Izdano: (2018-05-01)

MSH2 Overexpression Due to an Unclassified Variant in 3’-Untranslated Region in a Patient with Colon Cancer
od: Raffaella Liccardo, et al.
Izdano: (2020-06-01)

Modifier genes and Lynch syndrome: some considerations
od: Rodney J. Scott
Izdano: (2022-09-01)

Association of a novel point mutation in MSH2 gene with familial multiple primary cancers
od: Hai Hu, et al.
Izdano: (2017-10-01)

Two-Antibody Staining Method, A Cost-Saving Strategy for Universal Lynch Syndrome Screening in Endometrial Cancers
od: Natthakrit Anansitthikorn, et al.
Izdano: (2022-02-01)

Caracterización molecular de las mutaciones presentes en los genes responsables del síndrome de Lynch
od: Luis Isaza, et al.
Izdano: (2001-04-01)

Whole-genome sequencing identified novel mutations in a Chinese family with lynch syndrome
od: Wan He, et al.
Izdano: (2023-02-01)

MLH1 Ile219Val polymorphism in Argentinean families with suspected Lynch syndrome
od: Mev Dominguez-Valentin, et al.
Izdano: (2016-08-01)

Assessing the role of MSH2 and MSH6 gene expression deficiency in prostate cancer progression, a cross-sectional study
od: Fatemeh Sharbati, et al.
Izdano: (2024-01-01)

Acetaldehyde and defective mismatch repair increase colonic tumours in a Lynch syndrome model with Aldh1b1 inactivation
od: Guia Cerretelli, et al.
Izdano: (2023-08-01)

Report of a germline double heterozygote in MSH2 and PALB2
od: Konstantinos Agiannitopoulos, et al.
Izdano: (2020-10-01)

Case report: Undifferentiated sarcoma with multiple tumors involved in Lynch syndrome: Unexpected favorable outcome to sintilimab combined with chemotherapy
od: Jiaying Liu, et al.
Izdano: (2022-11-01)

Assessing the impact of MSH3 and MSH6 polymorphisms on lung cancer risk in North Indian patients undergoing platinum chemotherapy through molecular dynamics simulation
od: Sidhartha Singh, et al.
Izdano: (2024-07-01)

IMMUNOHISTOCHEMICAL STUDY OF MSH2, MSH6, PMS2, MLH1 IN EVALUATION OF DIFFERENTIATION GRADE OF COLON ADENOCARCINOMA
od: G. A. Raskin, et al.
Izdano: (2016-02-01)

Inhibition of Melanogenesis via Passive Immune Targeted Alpha-MSH Binder Polypeptide
od: Se-Hyo Jeong, et al.
Izdano: (2025-01-01)

Cytoplasmic MSH2 Related to Genomic Deletions in the MSH2/EPCAM Genes in Colorectal Cancer Patients With Suspected Lynch Syndrome
od: Lin Dong, et al.
Izdano: (2021-05-01)

Simultaneous Analysis of MLH1, MSH2, MSH6, PMS2 and KRAS in Patients with Gastric and Colon Cancer Using Stochastic Sensors
od: Damaris-Cristina Gheorghe, et al.
Izdano: (2022-09-01)

Correlations between MSH2 and MSH6 Concentrations in Different Biological Fluids and Clinicopathological Features in Colorectal Adenocarcinoma Patients and Their Contribution to Fast and Early Diagnosis of Colorectal Adenocarcinoma
od: Alexandru Adrian Bratei, et al.
Izdano: (2023-12-01)

MutS homologue hMSH5: role in cisplatin-induced DNA damage response
od: Tompkins Joshua D, et al.
Izdano: (2012-03-01)

Identificación del fenotipo de inestabilidad microsatelital en carcinoma colorrectal mediante el análisis de la expresión de proteínas reparadoras del ADN: Revisión narrativa
od: Orlando Rodas-Pernillo, et al.
Izdano: (2021-12-01)

Multiple colorectal adenomas in Lynch syndrome
od: Ayushi Jain, et al.
Izdano: (2022-12-01)