Structural insights into the mechanism of phosphoregulation of the retinoblastoma protein.

Structural insights into the mechanism of phosphoregulation of the retinoblastoma protein.

The retinoblastoma susceptibility protein RB1 is a key regulator of cell proliferation and fate. RB1 operates through nucleating the formation of multi-component protein complexes involved in the regulation of gene transcription, chromatin structure and protein stability. Phosphorylation of RB1 by c...

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Bibliographic Details
Main Authors: Ekaterina P Lamber, Fabienne Beuron, Edward P Morris, Dmitri I Svergun, Sibylle Mittnacht
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3597711?pdf=render

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