Efficacy of autologous platelet-rich plasma in the treatment of dormant corneal ulcer
Objective The aim of this study was to compare the clinical efficacy of platelet-rich plasma (PRP) eye drops to conventional therapy (preservative-free artificial tears and vitamin A gel drops) in the management of dormant corneal ulcer. Patients and methods This prospective study was conducted on 5...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Delta Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.djo.eg.net/article.asp?issn=1110-9173;year=2023;volume=24;issue=2;spage=86;epage=90;aulast=Basiony |
| Summary: | Objective The aim of this study was to compare the clinical efficacy of platelet-rich plasma (PRP) eye drops to conventional therapy (preservative-free artificial tears and vitamin A gel drops) in the management of dormant corneal ulcer.
Patients and methods This prospective study was conducted on 50 eyes of 50 patients with dormant corneal ulcer. The patients were randomized into two equal groups: group I, treated with PRP eye drops plus conventional therapy, and group II, treated with conventional therapy only. Corrected distance visual acuity, healing of corneal surface, and subjective symptoms were evaluated.
Results There was a statistically highly significant difference between the pretreatment and the 3-month posttreatment ulcer size in the PRP group (3.76±1.33 and 0.92±1.96 mm, respectively, P<0.001) as well as in the conventional group (4.12±0.97 and 2.72±2.28 mm, respectively, P=0.005). There was a statistically significant difference between the two groups regarding the degree of healing, favoring the PRP group (P=0.004), as clinical improvement was evident in 22 (88%) eyes in group I of which 18 (72%) eyes showed complete response and four (16%) eyes showed partial response, whereas in group II, clinical improvement was evident in 12 (48%) eyes, of which seven (28%) eyes showed complete response and five (20%) eyes showed partial response. There was a nonsignificant difference between the two groups regarding the pretreatment ulcer size (P=0.26). However, there was a significant difference between the two groups after 3 months regarding the ulcer size, the difference in ulcer size compared with the pretreatment size, and the symptom improvement, favoring the PRP group (P=0.002, 0.02, and 0.002, respectively). However, there was a nonsignificant difference between the two groups regarding the visual improvement (P=0.076). There were no complications related to the treatment in both groups.
Conclusions Autologous PRP seems to be an effective treatment for dormant corneal ulcers with better healing outcomes when compared with the conventional treatment. |
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| ISSN: | 1110-9173 2090-4835 |