Human B Cells Mediate Innate Anti-Cancer Cytotoxicity Through Concurrent Engagement of Multiple TNF Superfamily Ligands

Human B Cells Mediate Innate Anti-Cancer Cytotoxicity Through Concurrent Engagement of Multiple TNF Superfamily Ligands

The essential innate immunity effector cells, natural killer and dendritic cells, express multiple plasma membrane-associated tumor necrosis factor (TNF) superfamily (TNFSF) ligands that, through simultaneous and synergistic engagement, mediate anti-cancer cytotoxicity. Here, we report that circulat...

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Bibliographic Details
Main Authors: Bratislav M. Janjic, Aditi Kulkarni, Robert L. Ferris, Lazar Vujanovic, Nikola L. Vujanovic
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Immunology
Subjects:
B cells
cytotoxic
innate immunity
TNF superfamily ligands
cancer
head and neck squamous cell carcinoma
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.837842/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.837842/full

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